STRINGSTRING
GSK3B GSK3B PDGFB PDGFB SRC SRC GAB1 GAB1 MTOR MTOR JAK1 JAK1 BCL2 BCL2 IGF1R IGF1R JAK2 JAK2 RPS6KB1 RPS6KB1 EIF4E2 EIF4E2 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 EIF4EBP1 EIF4EBP1 PTEN PTEN NRAS NRAS PIK3CB PIK3CB KDR KDR GRB2 GRB2 PIK3R1 PIK3R1 IGF1 IGF1 PDGFC PDGFC PDGFD PDGFD IL6R IL6R RAF1 RAF1 NF1 NF1 SHC1 SHC1 PDGFA PDGFA VEGFA VEGFA PDGFRB PDGFRB LOC102271380 LOC102271380 MET MET FGF2 FGF2 BAD BAD BCL2L1 BCL2L1 LOC102269868 LOC102269868 RPS6 RPS6 FGFR2 FGFR2 PDGFRA PDGFRA AKT2 AKT2 STAT3 STAT3 PIK3CA PIK3CA ERBB3 ERBB3 SHC3 SHC3 HGF HGF EIF4E EIF4E MAP2K2 MAP2K2 PIK3R3 PIK3R3 FOXO3 FOXO3 TGFA TGFA KRAS KRAS PLCG2 PLCG2 SOS2 SOS2 RPS6KB2 RPS6KB2 IL6 IL6 SHC4 SHC4 AXL AXL GAS6 GAS6 PRKCG PRKCG PRKCA PRKCA PIK3R2 PIK3R2 ARAF ARAF MAPK3 MAPK3 AKT1 AKT1 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
SRCTyrosine-protein kinase. (559 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
JAK1Janus kinase 1. (1158 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (238 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
KDRKinase insert domain protein receptor. (1353 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (377 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
IL6RInterleukin-6 receptor subunit alpha. (399 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
NF1Neurofibromin. (2848 aa)
SHC1SHC-transforming protein 1. (501 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (222 aa)
VEGFAVascular endothelial growth factor A. (197 aa)
PDGFRBBeta-type platelet-derived growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
LOC102271380Uncharacterized protein. (174 aa)
METHepatocyte growth factor receptor. (1384 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
BADBcl2 antagonist of cell death. (168 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
RPS640S ribosomal protein S6. (249 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1336 aa)
SHC3SHC-transforming protein 3. (105 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (705 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FOXO3Forkhead box protein O3. (453 aa)
TGFATransforming growth factor, alpha. (160 aa)
KRASGTPase KRas. (189 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
IL6Interleukin-6. (254 aa)
SHC4SHC-transforming protein 4. (630 aa)
AXLTyrosine-protein kinase receptor UFO. (873 aa)
GAS6Growth arrest specific 6. (614 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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