STRINGSTRING
LOC102276866 LOC102276866 CASP3 CASP3 TOP2B TOP2B LOC102274807 LOC102274807 XPA XPA MSH3 MSH3 BCL2 BCL2 GSTM3 GSTM3 TOP2A TOP2A FASLG FASLG BBC3 BBC3 MLH1 MLH1 MSH2 MSH2 APAF1 APAF1 MSH6 MSH6 GSTO2 GSTO2 GSTO1 GSTO1 BIRC2 BIRC2 MGST1 MGST1 PIK3CB PIK3CB GSTA3 GSTA3 BID BID BAK1 BAK1 M91_13835 M91_13835 BIRC5 BIRC5 PIK3R1 PIK3R1 MDM2 MDM2 MGST2 MGST2 CDKN2A CDKN2A POLH POLH MAP3K5 MAP3K5 LOC102271380 LOC102271380 LOC102277620 LOC102277620 CDKN1A CDKN1A PMAIP1 PMAIP1 BAD BAD PDPK1 PDPK1 BCL2L1 BCL2L1 AKT2 AKT2 MGST3 MGST3 PIK3CA PIK3CA FAS FAS CASP8 CASP8 ATP7A ATP7A REV3L REV3L ABCC2 ABCC2 PIK3R3 PIK3R3 BIRC3 BIRC3 BRCA1 BRCA1 ERCC1 ERCC1 TP53 TP53 GSTA4 GSTA4 LOC102271929 LOC102271929 LOC102276661 LOC102276661 GSTT4 GSTT4 XIAP XIAP SLC31A1 SLC31A1 LOC106700494 LOC106700494 CASP9 CASP9 LOC102287938 LOC102287938 PIK3R2 PIK3R2 MAPK3 MAPK3 AKT1 AKT1 LOC102277261 LOC102277261
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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LOC102276866Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CASP3Caspase 3. (276 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1620 aa)
LOC102274807Glutathione S-transferase A1. (172 aa)
XPADNA repair protein complementing XP-A cells. (273 aa)
MSH3DNA mismatch repair protein MSH3. (1016 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
GSTM3Glutathione S-transferase. (225 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1530 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (277 aa)
BBC3Bcl-2-binding component 3. (131 aa)
MLH1DNA mismatch repair protein MLH1. (703 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
GSTO2Glutathione S-transferase omega-2; Belongs to the GST superfamily. (244 aa)
GSTO1Glutathione S-transferase omega-1. (344 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (623 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GSTA3Glutathione S-transferase. (222 aa)
BIDBH3-interacting domain death agonist. (193 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
M91_13835Serine-protein kinase ATM. (319 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoform 4. (153 aa)
POLHDNA polymerase eta. (710 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
LOC102271380Uncharacterized protein. (174 aa)
LOC102277620Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
BADBcl2 antagonist of cell death. (168 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FASTumor necrosis factor receptor superfamily member 6. (323 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (485 aa)
ATP7ACopper-transporting ATPase 1. (1500 aa)
REV3LDNA polymerase zeta catalytic subunit. (3055 aa)
ABCC2ATP-binding cassette, subfamily C (CFTR/MRP), member 2. (1538 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1828 aa)
ERCC1DNA excision repair protein ERCC-1. (304 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
GSTA4Glutathione S-transferase A4. (251 aa)
LOC102271929Glutathione S-transferase P. (239 aa)
LOC102276661Glutathione S-transferase theta-1; Belongs to the GST superfamily. (598 aa)
GSTT4Glutathione S-transferase theta-4. (247 aa)
XIAPBaculoviral IAP repeat-containing protein 4. (497 aa)
SLC31A1High affinity copper uptake protein 1. (188 aa)
LOC106700494Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (414 aa)
LOC102287938Glutathione S-transferase A2. (309 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
LOC102277261Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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