STRINGSTRING
RRAS2 RRAS2 GADD45G GADD45G NGFR NGFR RASGRP1 RASGRP1 PDGFB PDGFB TAB1 TAB1 ATF4 ATF4 IKBKB IKBKB MAP3K20 MAP3K20 TRAF2 TRAF2 RELA RELA MAP3K1 MAP3K1 MAP4K1 MAP4K1 CASP3 CASP3 MAP3K11 MAP3K11 LOC102269741 LOC102269741 MAP3K14 MAP3K14 RASGRP4 RASGRP4 CACNB1 CACNB1 NFKB2 NFKB2 HSPA8 HSPA8 EREG EREG AREG AREG FGF8 FGF8 NFATC3 NFATC3 RASGRF2 RASGRF2 CSF1 CSF1 MAP3K4 MAP3K4 NGF NGF FLT3LG FLT3LG ARRB1 ARRB1 EFNA2 EFNA2 RRAS RRAS EPHA2 EPHA2 LOC102278697 LOC102278697 LOC102278977 LOC102278977 CACNA1F CACNA1F IGF1R IGF1R FASLG FASLG TRADD TRADD FLNB FLNB ARRB2 ARRB2 CACNA1S CACNA1S DUSP10 DUSP10 FGF3 FGF3 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 MAP4K3 MAP4K3 MAP2K5 MAP2K5 TGFBR1 TGFBR1 TNFRSF1A TNFRSF1A NRAS NRAS PPM1B PPM1B MRAS MRAS MAP3K3 MAP3K3 FGFR4 FGFR4 PTPRR PTPRR KDR KDR FOS FOS IL1R1 IL1R1 HSPB1 HSPB1 DUSP4 DUSP4 IL1A IL1A IL1B IL1B MYC MYC CACNA2D4 CACNA2D4 CACNA1C-2 CACNA1C-2 NR4A1 NR4A1 TGFB2 TGFB2 LAMTOR3 LAMTOR3 GRB2 GRB2 TAOK1 TAOK1 DAXX DAXX CACNB2 CACNB2 TRAF6 TRAF6 RAP1A RAP1A IGF1 IGF1 MAP3K8 MAP3K8 PDGFC PDGFC PDGFD PDGFD GNG12 GNG12 GADD45A GADD45A ANGPT1 ANGPT1 MAP3K13 MAP3K13 RAF1 RAF1 FGFR1 FGFR1 NF1 NF1 FGF18 FGF18 RAP1B RAP1B RPS6KA5 RPS6KA5 FLT4 FLT4 PDGFA PDGFA MAPK9 MAPK9 VEGFA VEGFA MAP3K5 MAP3K5 PDGFRB PDGFRB LOC102271265 LOC102271265 EFNA4 EFNA4 EFNA3 EFNA3 EFNA1 EFNA1 MAP2K4 MAP2K4 SRF SRF TAOK3 TAOK3 MAPK13 MAPK13 FGF17 FGF17 MAPK14 MAPK14 HSPA2 HSPA2 TAB2 TAB2 GADD45B GADD45B DUSP7 DUSP7 CACNA2D3 CACNA2D3 TNF TNF FLNA FLNA PPP3CC PPP3CC MET MET MKNK2 MKNK2 LOC102269967 LOC102269967 RASGRP2 RASGRP2 FGF2 FGF2 RPS6KA4 RPS6KA4 IRAK4 IRAK4 EFNA5 EFNA5 IRAK1 IRAK1 HSPA1L HSPA1L MAPK7 MAPK7 PPP3CA PPP3CA CDC42 CDC42 CSF1R CSF1R LOC102269868 LOC102269868 FGFR2 FGFR2 PDGFRA PDGFRA CD14 CD14 NTF4 NTF4 MAPK12 MAPK12 MAPK11 MAPK11 NTRK1 NTRK1 AKT2 AKT2 STMN1 STMN1 ANGPT4 ANGPT4 TGFBR2 TGFBR2 MECOM MECOM FGF21 FGF21 RASA1 RASA1 MAP2K3 MAP2K3 RPS6KA1 RPS6KA1 FAS FAS MAP3K7 MAP3K7 MAPK8IP2 MAPK8IP2 ERBB3 ERBB3 MAP3K6 MAP3K6 FGF16 FGF16 RPS6KA3 RPS6KA3 CACNA1A CACNA1A RASGRP3 RASGRP3 HGF HGF DUSP5 DUSP5 CHUK CHUK DUSP6 DUSP6 KITLG-2 KITLG-2 CACNA2D1 CACNA2D1 MYD88 MYD88 PTPN7 PTPN7 LOC102285474 LOC102285474 MAP2K2 MAP2K2 FGF5 FGF5 PRKACA PRKACA NTRK2 NTRK2 DUSP3 DUSP3 MAX MAX MKNK1 MKNK1 CRKL CRKL PLA2G4B PLA2G4B NLK NLK PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F FGF9 FGF9 NFKB1 NFKB1 GNA12 GNA12 TGFA TGFA RELB-2 RELB-2 KRAS KRAS MAPK8 MAPK8 CACNG3 CACNG3 PPP3R1 PPP3R1 VEGFD VEGFD MAPKAPK3 MAPKAPK3 IGF2 IGF2 KIT KIT CACNA2D2 CACNA2D2 RASA2 RASA2 CACNB4 CACNB4 CDC25B CDC25B MAP3K12 MAP3K12 SOS2 SOS2 PAK2 PAK2 PTPN5 PTPN5 TP53 TP53 CACNA1E CACNA1E MAPK10 MAPK10 CACNA1G CACNA1G TEK TEK PLA2G4A PLA2G4A VEGFC VEGFC STK3 STK3 FGF7 FGF7 MAP3K2 MAP3K2 CACNB3 CACNB3 FGF10 FGF10 FLT1 FLT1 FLNC FLNC FLT3 FLT3 MAP2K6 MAP2K6 TGFB1 TGFB1 PAK1 PAK1 PRKACB PRKACB BDNF BDNF ELK4 ELK4 FGF20 FGF20 RAC2 RAC2 CACNG6 CACNG6 CACNG7 CACNG7 CACNG2 CACNG2 PRKCG PRKCG CACNA1D CACNA1D RAPGEF2 RAPGEF2 ATF2 ATF2 ANGPT2 ANGPT2 PPM1A PPM1A MAPKAPK2 MAPKAPK2 MAPKAPK5 MAPKAPK5 DDIT3 DDIT3 PRKCA PRKCA CACNG5 CACNG5 NTF3 NTF3 MAP2K7 MAP2K7 ARAF ARAF ELK1 ELK1 FGF6 FGF6 INSR INSR ECSIT ECSIT TAOK2 TAOK2 MAPK3 MAPK3 AKT1 AKT1 RASGRF1 RASGRF1 ERBB4 ERBB4 PPP3CB PPP3CB IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RRAS2Ras-related protein R-Ras2. (173 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (428 aa)
RASGRP1RAS guanyl-releasing protein 1. (797 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT. (800 aa)
TRAF2TNF receptor associated factor 2. (311 aa)
RELATranscription factor p65. (549 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1. (820 aa)
CASP3Caspase 3. (276 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (862 aa)
LOC102269741Stathmin; Belongs to the stathmin family. (137 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
RASGRP4RAS guanyl-releasing protein 4. (673 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1. (643 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
HSPA8Heat shock protein family A (Hsp70) member 8. (646 aa)
EREGProepiregulin. (169 aa)
AREGAmphiregulin. (269 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1038 aa)
RASGRF2Ras-specific guanine nucleotide-releasing factor 2. (1239 aa)
CSF1Macrophage colony-stimulating factor 1. (545 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1559 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (299 aa)
FLT3LGSL cytokine. (292 aa)
ARRB1Beta-arrestin-1. (429 aa)
EFNA2Ephrin-A2; Belongs to the ephrin family. (203 aa)
RRASRas-related protein R-Ras. (218 aa)
EPHA2EPH receptor A2. (975 aa)
LOC102278697Heat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (599 aa)
LOC102278977Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (633 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1965 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (277 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (354 aa)
FLNBFilamin-B. (2633 aa)
ARRB2Arrestin beta 2. (401 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3. (842 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
NRASGTPase NRas. (189 aa)
PPM1BProtein phosphatase, Mg2+/Mn2+ dependent 1B. (479 aa)
MRASRas-related protein M-Ras. (208 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
FGFR4Fibroblast growth factor receptor. (799 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R. (655 aa)
KDRKinase insert domain protein receptor. (1353 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (552 aa)
CACNA1C-2Voltage-dependent calcium channel L type alpha-1C. (1249 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (627 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LAMTOR3Mitogen-activated protein kinase scaffold protein 1. (124 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
TAOK1Serine/threonine-protein kinase TAO1. (1001 aa)
DAXXDeath domain-associated protein 6. (748 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2. (658 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
IGF1Insulin-like growth factor I. (194 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (377 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
ANGPT1Angiopoietin-1. (498 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
FGFR1Basic fibroblast growth factor receptor 1. (852 aa)
NF1Neurofibromin. (2848 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (723 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (222 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
VEGFAVascular endothelial growth factor A. (197 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
PDGFRBBeta-type platelet-derived growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
LOC102271265Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
EFNA4Ephrin-A4; Belongs to the ephrin family. (326 aa)
EFNA3Ephrin-A3; Belongs to the ephrin family. (238 aa)
EFNA1Ephrin-A1; Belongs to the ephrin family. (317 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
SRFSerum response factor. (467 aa)
TAOK3Serine/threonine-protein kinase TAO3. (898 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
HSPA2Heat shock protein family A (Hsp70) member 2. (623 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2. (409 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
DUSP7Dual specificity protein phosphatase 7. (381 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3. (1080 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FLNAFilamin-A. (2647 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
METHepatocyte growth factor receptor. (1384 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (464 aa)
LOC102269967Ras-related protein Rap-1b-like. (184 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
RPS6KA4Ribosomal protein S6 kinase alpha-4. (773 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (461 aa)
EFNA5Ephrin-A5; Belongs to the ephrin family. (188 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (640 aa)
HSPA1LHeat shock 70 kDa protein 1-like protein; Belongs to the heat shock protein 70 family. (641 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (782 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (958 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
CD14Monocyte differentiation antigen CD14. (383 aa)
NTF4Neurotrophin 4. (210 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STMN1Stathmin; Belongs to the stathmin family. (149 aa)
ANGPT4Angiopoietin-4. (498 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MECOMUncharacterized protein. (1230 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
RASA1Ras GTPase-activating protein 1. (1048 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
FASTumor necrosis factor receptor superfamily member 6. (323 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (540 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1336 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1283 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (712 aa)
CACNA1AVoltage-dependent calcium channel P/Q type alpha-1A. (2312 aa)
RASGRP3Ras guanyl-releasing protein 3. (692 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (705 aa)
DUSP5Dual specificity protein phosphatase 5; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (373 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
KITLG-2Kit ligand. (196 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1. (1103 aa)
MYD88Myeloid differentiation primary response protein MyD88. (296 aa)
PTPN7Protein tyrosine phosphatase, non-receptor type 7. (211 aa)
LOC102285474Nuclear factor of activated T-cells, cytoplasmic 1-like. (454 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (125 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (117 aa)
MAXProtein max. (160 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (426 aa)
CRKLCrk-like protein. (302 aa)
PLA2G4BPhospholipase A2. (784 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (516 aa)
PLA2G4EPhospholipase A2. (860 aa)
PLA2G4DPhospholipase A2. (808 aa)
PLA2G4FPhospholipase A2. (844 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (291 aa)
TGFATransforming growth factor, alpha. (160 aa)
RELB-2RELB proto-oncogene, NF-kB subunit. (101 aa)
KRASGTPase KRas. (189 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
IGF2Insulin-like growth factor II. (261 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2. (1153 aa)
RASA2Ras GTPase-activating protein 2. (852 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4. (520 aa)
CDC25BM-phase inducer phosphatase 2. (619 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PTPN5Tyrosine-protein phosphatase non-receptor type 5. (541 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2315 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
PLA2G4APhospholipase A2. (749 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
STK3Serine/threonine-protein kinase 3. (482 aa)
FGF7Fibroblast growth factor 7. (194 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (620 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3. (484 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
FLNCFilamin-C. (2720 aa)
FLT3FL cytokine receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
ELK4ETS domain-containing protein Elk-4. (452 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit. (260 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG2Calcium voltage-gated channel auxiliary subunit gamma 2. (294 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1676 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
ANGPT2Angiopoietin-2. (496 aa)
PPM1AProtein phosphatase 1A. (454 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MAPKAPK5MAP kinase-activated protein kinase 5. (472 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (279 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
INSRInsulin receptor. (1382 aa)
ECSITEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial. (432 aa)
TAOK2Serine/threonine-protein kinase TAO2. (1235 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1. (1257 aa)
ERBB4Receptor tyrosine-protein kinase erbB-4. (804 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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