STRINGSTRING
GSK3B GSK3B PRKCD PRKCD GNGT2 GNGT2 SRC SRC CCL22 CCL22 GNAI1 GNAI1 CCL17 CCL17 IKBKB IKBKB PLCB2 PLCB2 GRK3 GRK3 RELA RELA CXCL14 CXCL14 GNB2 GNB2 CXCL8 CXCL8 CXCL6 CXCL6 PPBP PPBP LOC102269246 LOC102269246 LOC102269855 LOC102269855 CCR9 CCR9 CXCR6 CXCR6 XCR1 XCR1 LOC102287450 LOC102287450 CCR3 CCR3 CCR2 CCR2 PARD3 PARD3 CCR5 CCR5 VAV3 VAV3 ADCY9 ADCY9 NFKBIA NFKBIA GNAI3 GNAI3 ARRB1 ARRB1 GNGT1 GNGT1 GNG11 GNG11 CCR7 CCR7 ARRB2 ARRB2 CXCL16 CXCL16 DOCK2 DOCK2 GNG2 GNG2 JAK2 JAK2 GNG8 GNG8 WAS WAS ADCY8 ADCY8 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 ADCY1 ADCY1 NRAS NRAS ADCY3 ADCY3 PIK3CB PIK3CB CXCL12 CXCL12 GRK6 GRK6 GSK3A GSK3A CCL24 CCL24 CCL26 CCL26 ELMO1 ELMO1 PIK3CG PIK3CG ADCY4 ADCY4 CCR4 CCR4 GRB2 GRB2 GNG4 GNG4 PREX1 PREX1 GNB3 GNB3 RAP1A RAP1A PIK3R1 PIK3R1 GNB5 GNB5 GNG12 GNG12 RAF1 RAF1 TIAM1 TIAM1 SHC1 SHC1 RAP1B RAP1B NCF1 NCF1 LYN LYN PIK3R5 PIK3R5 PIK3R6 PIK3R6 LOC102271265 LOC102271265 LOC102287335 LOC102287335 LOC102287625 LOC102287625 LOC102272762 LOC102272762 LOC102288203 LOC102288203 CCL14 CCL14 CCL16 CCL16 CCL5 CCL5 PTK2 PTK2 GNG7 GNG7 CCL1 CCL1 LOC102270698 LOC102270698 CCL11 CCL11 CCL2 CCL2 LOC102269967 LOC102269967 RASGRP2 RASGRP2 CCL20 CCL20 CXCL13 CXCL13 RHOA RHOA LOC102285258 LOC102285258 LOC102285534 LOC102285534 BAD BAD NFKBIB NFKBIB PLCB3 PLCB3 CXCL11 CXCL11 HCK HCK CDC42 CDC42 ITK ITK CCR10 CCR10 AKT2 AKT2 STAT1 STAT1 STAT3 STAT3 STAT5B STAT5B PIK3CA PIK3CA GNAQ GNAQ GNB4 GNB4 PTK2B PTK2B CXCL9 CXCL9 SHC3 SHC3 FGR FGR CHUK CHUK ROCK2 ROCK2 STAT2 STAT2 CCL27 CCL27 CCL19 CCL19 CCL21 CCL21 PIK3R3 PIK3R3 PRKACA PRKACA FOXO3 FOXO3 CRKL CRKL NFKB1 NFKB1 CXCR4 CXCR4 KRAS KRAS PLCG2 PLCG2 CCR6 CCR6 GRK7 GRK7 GRK2 GRK2 SOS2 SOS2 GNAI2 GNAI2 ROCK1 ROCK1 BCAR1 BCAR1 PLCB1 PLCB1 SHC4 SHC4 ADCY6 ADCY6 CCL28 CCL28 GNG3 GNG3 PRKCZ PRKCZ PAK1 PAK1 GNG13 GNG13 GNB1 GNB1 GRK1 GRK1 GNG5 GNG5 PRKACB PRKACB CX3CR1 CX3CR1 CXCR3 CXCR3 RAC2 RAC2 GRK4 GRK4 VAV1 VAV1 JAK3 JAK3 PIK3R2 PIK3R2 ADCY7 ADCY7 CXCR2 CXCR2 CXCR1 CXCR1 CCL25 CCL25 MAPK3 MAPK3 AKT1 AKT1 PLCG1 PLCG1 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (80 aa)
SRCTyrosine-protein kinase. (559 aa)
CCL22C-C motif chemokine. (93 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha. (354 aa)
CCL17C-C motif chemokine. (102 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
RELATranscription factor p65. (549 aa)
CXCL14C-X-C motif chemokine 14. (99 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (296 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CXCL6C-X-C motif chemokine. (112 aa)
PPBPC-X-C motif chemokine. (119 aa)
LOC102269246C-X-C motif chemokine. (103 aa)
LOC102269855Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCR9C-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family. (367 aa)
CXCR6C-X-C motif chemokine receptor 6. (340 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
LOC102287450C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CCR2C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PARD3Partitioning defective 3-like protein. (1029 aa)
CCR5C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
VAV3Guanine nucleotide exchange factor VAV3. (874 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ARRB1Beta-arrestin-1. (429 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11. (73 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
ARRB2Arrestin beta 2. (401 aa)
CXCL16C-X-C motif chemokine 16. (252 aa)
DOCK2Dedicator of cytokinesis protein 2. (970 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
WASWiskott-Aldrich syndrome protein. (514 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
ADCY1Adenylate cyclase 1. (310 aa)
NRASGTPase NRas. (189 aa)
ADCY3Adenylate cyclase type 3. (1145 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CXCL12C-X-C motif chemokine ligand 12. (119 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (582 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
CCL24C-C motif chemokine 24. (116 aa)
CCL26C-C motif chemokine. (94 aa)
ELMO1Engulfment and cell motility protein 1. (727 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1104 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1650 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (356 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (353 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1. (1591 aa)
SHC1SHC-transforming protein 1. (501 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
NCF1Neutrophil cytosol factor 1. (392 aa)
LYNTyrosine-protein kinase. (512 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5/6. (886 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
LOC102271265Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC102287335C-C motif chemokine. (92 aa)
LOC102287625C-C motif chemokine. (125 aa)
LOC102272762C-C motif chemokine. (93 aa)
LOC102288203C-C motif chemokine 23. (146 aa)
CCL14C-C motif chemokine 14. (94 aa)
CCL16C-C motif chemokine. (118 aa)
CCL5C-C motif chemokine. (91 aa)
PTK2Focal adhesion kinase 1. (1065 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCL1C-C motif chemokine 1. (96 aa)
LOC102270698C-C motif chemokine. (139 aa)
CCL11C-C motif chemokine. (97 aa)
CCL2C-C motif chemokine. (99 aa)
LOC102269967Ras-related protein Rap-1b-like. (184 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
CCL20C-C motif chemokine. (96 aa)
CXCL13C-X-C motif chemokine. (109 aa)
RHOATransforming protein RhoA. (193 aa)
LOC102285258C motif chemokine 1. (107 aa)
LOC102285534Lymphotactin. (112 aa)
BADBcl2 antagonist of cell death. (168 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
CXCL11C-X-C motif chemokine. (95 aa)
HCKTyrosine-protein kinase. (524 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
ITKNon-specific protein-tyrosine kinase. (424 aa)
CCR10C-C chemokine receptor type 10; Belongs to the G-protein coupled receptor 1 family. (365 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT1Signal transducer and activator of transcription. (817 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5BSignal transducer and activator of transcription 5B. (787 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CXCL9C-X-C motif chemokine. (125 aa)
SHC3SHC-transforming protein 3. (105 aa)
FGRTyrosine-protein kinase. (527 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1297 aa)
STAT2Signal transducer and activator of transcription. (857 aa)
CCL27C-C motif chemokine 27. (113 aa)
CCL19C-C motif chemokine. (115 aa)
CCL21C-C motif chemokine 21. (133 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
FOXO3Forkhead box protein O3. (453 aa)
CRKLCrk-like protein. (302 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
KRASGTPase KRas. (189 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (552 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (866 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
SHC4SHC-transforming protein 4. (630 aa)
ADCY6Adenylate cyclase 6. (1163 aa)
CCL28C-C motif chemokine ligand 28. (129 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKCZProtein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (592 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (561 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CX3CR1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (367 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
GRK4G protein-coupled receptor kinase 4. (568 aa)
VAV1Proto-oncogene vav. (844 aa)
JAK3Tyrosine-protein kinase. (1133 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
CXCR2C-X-C motif chemokine receptor 2. (349 aa)
CXCR1C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
CCL25C-C motif chemokine 25. (201 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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