STRINGSTRING
MTOR MTOR RELA RELA PFKFB3 PFKFB3 PDK1 PDK1 PFKM PFKM ALDOB ALDOB CUL2 CUL2 EDN1 EDN1 CREBBP CREBBP BCL2 BCL2 PDHB PDHB PFKP PFKP IGF1R IGF1R LDHB LDHB RPS6KB1 RPS6KB1 TF TF ENO3 ENO3 EIF4E2 EIF4E2 MAP2K1 MAP2K1 SERPINE1 SERPINE1 EIF4EBP1 EIF4EBP1 LTBR LTBR PIK3CB PIK3CB SLC2A1 SLC2A1 ALDOC ALDOC EGLN3 EGLN3 GAPDH GAPDH IFNGR2 IFNGR2 RBX1-2 RBX1-2 CDKN1B CDKN1B TLR4 TLR4 ENO2 ENO2 PIK3R1 PIK3R1 IGF1 IGF1 ELOC ELOC ANGPT1 ANGPT1 CYBB CYBB IL6R IL6R VHL VHL IFNG IFNG PGK2 PGK2 NOS2 NOS2 VEGFA VEGFA IFNGR1 IFNGR1 CAMK2A CAMK2A CDKN1A CDKN1A NPPA NPPA PDHA2 PDHA2 PFKL PFKL HK2 HK2 MKNK2 MKNK2 HMOX1 HMOX1 ELOB ELOB HK1 HK1 LOC102269868 LOC102269868 RPS6 RPS6 AKT2 AKT2 ANGPT4 ANGPT4 EP300 EP300 STAT3 STAT3 PIK3CA PIK3CA PDHA1 PDHA1 PGK1 PGK1 EIF4E EIF4E EPO EPO HK3 HK3 MAP2K2 MAP2K2 PIK3R3 PIK3R3 MKNK1 MKNK1 NFKB1 NFKB1 EGLN1 EGLN1 PLCG2 PLCG2 TFRC TFRC RPS6KB2 RPS6KB2 IL6 IL6 LOC102274962 LOC102274962 HKDC1 HKDC1 TEK TEK EGLN2 EGLN2 FLT1 FLT1 ARNT ARNT PRKCG PRKCG ANGPT2 ANGPT2 LOC102265644 LOC102265644 HIF1A HIF1A PRKCA PRKCA PIK3R2 PIK3R2 TIMP1 TIMP1 INSR INSR ENO4 ENO4 ALDOA ALDOA MAPK3 MAPK3 AKT1 AKT1 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
RELATranscription factor p65. (549 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. (534 aa)
PDK1Protein-serine/threonine kinase. (437 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
EDN1Endothelin-1. (202 aa)
CREBBPCREB-binding protein. (2203 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (783 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
TFTransferrin isoform X1; Belongs to the transferrin family. (704 aa)
ENO3Enolase 3. (440 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (238 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (380 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
EGLN3Egl nine-like protein 3. (248 aa)
GAPDHGlyceraldehyde 3-phosphate dehydrogenase. (379 aa)
IFNGR2Interferon gamma receptor 2. (363 aa)
RBX1-2E3 ubiquitin-protein ligase RBX1. (96 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (801 aa)
ENO2Gamma-enolase. (434 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
ELOCTranscription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
ANGPT1Angiopoietin-1. (498 aa)
CYBBCytochrome b-245 heavy chain. (570 aa)
IL6RInterleukin-6 receptor subunit alpha. (399 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (216 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PGK2Phosphoglycerate kinase. (417 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
VEGFAVascular endothelial growth factor A. (197 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
NPPAAtrial natriuretic factor. (188 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
PFKL6-phosphofructokinase, liver type. (751 aa)
HK2Hexokinase-2. (917 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (464 aa)
HMOX1Heme oxygenase 1. (289 aa)
ELOBTranscription elongation factor B polypeptide 2. (113 aa)
HK1Hexokinase 1. (839 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
RPS640S ribosomal protein S6. (249 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ANGPT4Angiopoietin-4. (498 aa)
EP300E1A binding protein p300. (2371 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
PGK1Phosphoglycerate kinase. (417 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
EPOErythropoietin. (192 aa)
HK3Hexokinase-3. (924 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (426 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
EGLN1Egl nine-like protein 1. (426 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
TFRCTransferrin receptor protein 1. (769 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
IL6Interleukin-6. (254 aa)
LOC102274962L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
EGLN2Egl nine-like protein 2. (415 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (790 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
ANGPT2Angiopoietin-2. (496 aa)
LOC102265644Transcription elongation factor B polypeptide 2. (118 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (255 aa)
INSRInsulin receptor. (1382 aa)
ENO4Enolase-like protein ENO4. (613 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (445 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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