STRINGSTRING
GADD45G GADD45G IKBKB IKBKB IL7R IL7R SOD2 SOD2 CREBBP CREBBP G6PC2 G6PC2 CCNB3 CCNB3 STK11 STK11 IGF1R IGF1R CDKN2D CDKN2D PRMT1 PRMT1 FASLG FASLG PLK2 PLK2 CCND1 CCND1 MAP2K1 MAP2K1 CCNB2 CCNB2 TNFSF10 TNFSF10 SMAD3 SMAD3 HRAS HRAS SOS1 SOS1 TGFBR1 TGFBR1 PTEN PTEN NRAS NRAS HOMER2 HOMER2 PIK3CB PIK3CB SLC2A4 SLC2A4 GABARAP GABARAP FOXG1 FOXG1 PRKAG2 PRKAG2 SGK1 SGK1 TGFB2 TGFB2 CAT CAT GRB2 GRB2 PRKAA2 PRKAA2 PRKAB2 PRKAB2 GABARAPL1 GABARAPL1 CDKN1B CDKN1B M91_13835 M91_13835 RAG1 RAG1 RAG2 RAG2 PIK3R1 PIK3R1 IGF1 IGF1 FBXO32 FBXO32 GADD45A GADD45A RBL2 RBL2 RAF1 RAF1 MDM2 MDM2 SETD7 SETD7 MAPK9 MAPK9 BCL6 BCL6 CDKN1A CDKN1A S1PR4 S1PR4 MAPK13 MAPK13 MAPK14 MAPK14 GADD45B GADD45B S1PR1 S1PR1 IRS1 IRS1 GRM1 GRM1 SGK2 SGK2 CCNG2 CCNG2 SGK3 SGK3 ATG12 ATG12 PDPK1 PDPK1 HOMER3 HOMER3 LOC102269868 LOC102269868 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 TGFBR2 TGFBR2 EP300 EP300 STAT3 STAT3 PIK3CA PIK3CA PLK3 PLK3 PCK1 PCK1 FBXO25 FBXO25 HOMER1 HOMER1 CHUK CHUK FOXO1 FOXO1 SKP2 SKP2 MAP2K2 MAP2K2 PIK3R3 PIK3R3 G6PC3 G6PC3 FOXO3 FOXO3 G6PC G6PC NLK NLK KRAS KRAS IRS4 IRS4 MAPK8 MAPK8 SOS2 SOS2 PRKAB1 PRKAB1 IL6 IL6 MAPK10 MAPK10 USP7 USP7 PLK1 PLK1 SIRT1 SIRT1 PRKAG1 PRKAG1 TGFB1 TGFB1 SMAD4 SMAD4 CCNB1 CCNB1 PCK2 PCK2 FOXO4 FOXO4 IL10 IL10 AGAP2 AGAP2 PIK3R2 PIK3R2 ARAF ARAF CCND2 CCND2 PRKAG3 PRKAG3 INSR INSR PRKAA1 PRKAA1 MAPK3 MAPK3 AKT1 AKT1 LOC102286770 LOC102286770
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
IL7RInterleukin-7 receptor subunit alpha. (459 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (215 aa)
CREBBPCREB-binding protein. (2203 aa)
G6PC2Glucose-6-phosphatase 2. (355 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1307 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (151 aa)
PRMT1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (277 aa)
PLK2Serine/threonine-protein kinase PLK. (659 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
HOMER2Homer protein-like protein 2. (344 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
FOXG1Forkhead box protein G1. (151 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (317 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
M91_13835Serine-protein kinase ATM. (319 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
FBXO32F-box only protein 32. (355 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
RBL2Retinoblastoma-like protein 2. (1140 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
SETD7Histone-lysine N-methyltransferase SETD7. (384 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
S1PR4Sphingosine 1-phosphate receptor 4. (385 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
S1PR1Sphingosine 1-phosphate receptor 1. (382 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
GRM1Glutamate metabotropic receptor 1. (1092 aa)
SGK2Serine/threonine-protein kinase Sgk2; Belongs to the protein kinase superfamily. (564 aa)
CCNG2Cyclin-G2; Belongs to the cyclin family. (344 aa)
SGK3Serine/threonine-protein kinase Sgk3; Belongs to the protein kinase superfamily. (496 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (145 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
HOMER3Homer protein-like protein 3. (358 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EP300E1A binding protein p300. (2371 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
FBXO25F-box only protein 25. (367 aa)
HOMER1Homer protein-like protein 1. (374 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
FOXO1Forkhead box protein O1. (468 aa)
SKP2S-phase kinase-associated protein 2. (408 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
G6PC3Glucose-6-phosphatase 3. (453 aa)
FOXO3Forkhead box protein O3. (453 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (356 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (516 aa)
KRASGTPase KRas. (189 aa)
IRS4Insulin receptor substrate 4. (1207 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (297 aa)
IL6Interleukin-6. (254 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7. (1084 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (454 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (349 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
FOXO4Forkhead box protein O4. (512 aa)
IL10Interleukin-10. (179 aa)
AGAP2Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (932 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (284 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (496 aa)
INSRInsulin receptor. (1382 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
LOC102286770Casein kinase I isoform epsilon; Belongs to the protein kinase superfamily. (416 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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