STRINGSTRING
RRAS2 RRAS2 GRM8 GRM8 FCER1G FCER1G PDGFB PDGFB GAB1 GAB1 M91_06687 M91_06687 PLCB2 PLCB2 AGPAT2 AGPAT2 MTOR MTOR RAPGEF4 RAPGEF4 RAPGEF3 RAPGEF3 LPAR6 LPAR6 LOC102280438 LOC102280438 GRM7 GRM7 MS4A2 MS4A2 CXCL8 CXCL8 GRM6 GRM6 ADCY9 ADCY9 DGKH DGKH AGPAT4 AGPAT4 ENSBMUP00000004277 ENSBMUP00000004277 PLPP2 PLPP2 DNM2 DNM2 RRAS RRAS RALA RALA TSC1 TSC1 RALGDS RALGDS FCER1A FCER1A PLD2 PLD2 ADCY8 ADCY8 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 ADCY1 ADCY1 NRAS NRAS ADCY3 ADCY3 PLD1 PLD1 MRAS MRAS PIK3CB PIK3CB AGT AGT PIK3CG PIK3CG ADCY4 ADCY4 M91_02843 M91_02843 GRB2 GRB2 PTPN11 PTPN11 PTGFR PTGFR LPAR5 LPAR5 CYTH1 CYTH1 PLPP3 PLPP3 PIP5K1B PIP5K1B LPAR3 LPAR3 PIK3R1 PIK3R1 SYK SYK PDGFC PDGFC PDGFD PDGFD DGKE DGKE SPHK1 SPHK1 GRM3 GRM3 RAF1 RAF1 F2R F2R SHC1 SHC1 PDGFA PDGFA PIK3R5 PIK3R5 PIK3R6 PIK3R6 GAB2 GAB2 PDGFRB PDGFRB AVPR2 AVPR2 AGPAT3 AGPAT3 ARF1 ARF1 CYTH3 CYTH3 GRM1 GRM1 LPAR4 LPAR4 RHOA RHOA PLCB3 PLCB3 DGKI DGKI LOC102269868 LOC102269868 PDGFRA PDGFRA AKT2 AKT2 SPHK2 SPHK2 PIK3CA PIK3CA PTK2B PTK2B FYN FYN SHC3 SHC3 TSC2 TSC2 DGKA DGKA DGKG DGKG KITLG-2 KITLG-2 PIP5K1C PIP5K1C MAP2K2 MAP2K2 PIK3R3 PIK3R3 RALB RALB PLA2G4B PLA2G4B LOC102266153 LOC102266153 PLA2G4E PLA2G4E PLA2G4D PLA2G4D LPAR2 LPAR2 PLA2G4F PLA2G4F GNA12 GNA12 KRAS KRAS DNM1 DNM1 DGKB DGKB KIT KIT PLCG2 PLCG2 SOS2 SOS2 ARF6 ARF6 DNM3 DNM3 PLCB1 PLCB1 AGTR1 AGTR1 PLA2G4A PLA2G4A SHC4 SHC4 ADCY6 ADCY6 GRM2 GRM2 F2 F2 LPAR1 LPAR1 AGPAT1 AGPAT1 PIP5K1A PIP5K1A CYTH4 CYTH4 DGKQ DGKQ AVPR1A AVPR1A AGPAT5 AGPAT5 DGKD DGKD GNA13 GNA13 PRKCA PRKCA PIK3R2 PIK3R2 ADCY7 ADCY7 CXCR2 CXCR2 CXCR1 CXCR1 INSR INSR MAPK3 MAPK3 AKT1 AKT1 PLCG1 PLCG1 AVPR1B AVPR1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRAS2Ras-related protein R-Ras2. (173 aa)
GRM8Metabotropic glutamate receptor 8. (908 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (111 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
M91_06687Ig heavy chain V region MC101. (200 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (200 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1007 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
LPAR6Lysophosphatidic acid receptor 6. (341 aa)
LOC102280438ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family. (181 aa)
GRM7Metabotropic glutamate receptor 7. (915 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta. (242 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
GRM6Glutamate metabotropic receptor 6. (876 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
DGKHDiacylglycerol kinase (ATP). (1217 aa)
AGPAT4Lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase. (211 aa)
ENSBMUP00000004277Lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase. (113 aa)
PLPP2Lipid phosphate phosphohydrolase 2. (300 aa)
DNM2Dynamin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
RRASRas-related protein R-Ras. (218 aa)
RALARas-related protein Ral-A. (206 aa)
TSC1Hamartin. (1159 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (874 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha. (253 aa)
PLD2Phospholipase. (933 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
ADCY1Adenylate cyclase 1. (310 aa)
NRASGTPase NRas. (189 aa)
ADCY3Adenylate cyclase type 3. (1145 aa)
PLD1Phospholipase. (1074 aa)
MRASRas-related protein M-Ras. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
AGTAngiotensinogen; Belongs to the serpin family. (456 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1104 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
PTGFRProstaglandin F2-alpha receptor. (362 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (347 aa)
CYTH1Cytohesin-1. (455 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (311 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type-1 beta. (546 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SYKNon-specific protein-tyrosine kinase. (629 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (377 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
DGKEDiacylglycerol kinase. (564 aa)
SPHK1Sphingosine kinase 1. (475 aa)
GRM3Metabotropic glutamate receptor 3. (879 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (422 aa)
SHC1SHC-transforming protein 1. (501 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (222 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5/6. (886 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
GAB2GRB2-associated-binding protein 2. (666 aa)
PDGFRBBeta-type platelet-derived growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
AVPR2Arginine vasopressin receptor 2. (336 aa)
AGPAT31-acyl-sn-glycerol-3-phosphate acyltransferase gamma. (376 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
CYTH3Cytohesin-3. (399 aa)
GRM1Glutamate metabotropic receptor 1. (1092 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
RHOATransforming protein RhoA. (193 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
DGKIDiacylglycerol kinase (ATP). (1075 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SPHK2Sphingosine kinase 2. (653 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
FYNTyrosine-protein kinase. (537 aa)
SHC3SHC-transforming protein 3. (105 aa)
TSC2Tuberous sclerosis 2. (1812 aa)
DGKADiacylglycerol kinase (ATP). (729 aa)
DGKGDiacylglycerol kinase. (791 aa)
KITLG-2Kit ligand. (196 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type-1 gamma. (668 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RALBRas-related protein Ral-B. (234 aa)
PLA2G4BPhospholipase A2. (784 aa)
LOC102266153Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (394 aa)
PLA2G4EPhospholipase A2. (860 aa)
PLA2G4DPhospholipase A2. (808 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
PLA2G4FPhospholipase A2. (844 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (291 aa)
KRASGTPase KRas. (189 aa)
DNM1Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
DGKBDiacylglycerol kinase. (803 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
DNM3Dynamin-3. (869 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
PLA2G4APhospholipase A2. (749 aa)
SHC4SHC-transforming protein 4. (630 aa)
ADCY6Adenylate cyclase 6. (1163 aa)
GRM2Metabotropic glutamate receptor 2. (872 aa)
F2Prothrombin; Belongs to the peptidase S1 family. (625 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
PIP5K1APutative PIP5K1A and PSMD4-like protein. (562 aa)
CYTH4Cytohesin-4. (394 aa)
DGKQDiacylglycerol kinase. (844 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (419 aa)
AGPAT51-acyl-sn-glycerol-3-phosphate acyltransferase epsilon. (365 aa)
DGKDDiacylglycerol kinase (ATP). (1183 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
CXCR2C-X-C motif chemokine receptor 2. (349 aa)
CXCR1C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
INSRInsulin receptor. (1382 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
Server load: low (16%) [HD]