STRINGSTRING
RRAS2 RRAS2 ULK1 ULK1 PRKCD PRKCD C9orf72 C9orf72 EIF2AK4 EIF2AK4 PRKCQ PRKCQ MTOR MTOR CTSV CTSV CTSB CTSB PPP2CA PPP2CA ATG2B ATG2B BCL2 BCL2 RRAS RRAS STK11 STK11 DAPK2 DAPK2 IGF1R IGF1R TSC1 TSC1 ATG4D ATG4D VMP1 VMP1 AKT1S1 AKT1S1 RRAGC RRAGC RPS6KB1 RPS6KB1 TP53INP2 TP53INP2 MAP2K1 MAP2K1 NRBF2 NRBF2 HRAS HRAS STX17 STX17 PTEN PTEN NRAS NRAS MRAS MRAS PIK3CB PIK3CB GABARAP GABARAP RAB39B RAB39B RUBCN RUBCN ATG2A ATG2A ATG7 ATG7 ATG10 ATG10 M91_02843 M91_02843 RRAGB RRAGB ATG101 ATG101 ERN1 ERN1 EIF2S1 EIF2S1 PRKAA2 PRKAA2 GABARAPL1 GABARAPL1 TRAF6 TRAF6 RAB8A RAB8A ATG14 ATG14 ZFYVE1 ZFYVE1 PIK3R1 PIK3R1 ATG3 ATG3 WDR41 WDR41 RAF1 RAF1 RAB33B RAB33B ATG4B ATG4B MTMR14 MTMR14 MAPK9 MAPK9 LOC102271380 LOC102271380 LAMP1 LAMP1 RB1CC1 RB1CC1 IRS1 IRS1 SUPT20H SUPT20H RAB7A RAB7A BAD BAD ATG12 ATG12 ULK2 ULK2 SQSTM1 SQSTM1 BECN2 BECN2 PDPK1 PDPK1 BCL2L1 BCL2L1 RRAGA RRAGA BECN1 BECN1 SMCR8 SMCR8 MLST8 MLST8 AKT2 AKT2 ITPR1 ITPR1 IGBP1 IGBP1 PIK3CA PIK3CA MAP3K7 MAP3K7 PPP2CB PPP2CB ENSBMUP00000022382 ENSBMUP00000022382 TANK TANK DDIT4 DDIT4 SH3GLB1 SH3GLB1 TSC2 TSC2 RAB7B RAB7B RPTOR RPTOR DAPK1 DAPK1 CTSL CTSL PIK3R4 PIK3R4 DAPK3 DAPK3 CAMKK2 CAMKK2 MAP2K2 MAP2K2 PIK3R3 PIK3R3 PRKACA PRKACA SNAP29 SNAP29 CTSD CTSD KRAS KRAS RAB1A RAB1A IRS4 IRS4 MAPK8 MAPK8 ATG4A ATG4A MTMR4 MTMR4 WIPI2 WIPI2 RRAGD RRAGD ATG4C ATG4C RPS6KB2 RPS6KB2 MAPK10 MAPK10 PIK3C3 PIK3C3 LAMP2 LAMP2 HMGB1 HMGB1 ATG5 ATG5 AMBRA1 AMBRA1 ATG13 ATG13 PRKACB PRKACB UVRAG UVRAG TBK1 TBK1 ATG16L1 ATG16L1 HIF1A HIF1A MTMR3 MTMR3 VAMP8 VAMP8 PIK3R2 PIK3R2 ATG9A ATG9A DEPTOR DEPTOR PRKAA1 PRKAA1 MAPK3 MAPK3 AKT1 AKT1 CFLAR CFLAR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRAS2Ras-related protein R-Ras2. (173 aa)
ULK1Serine/threonine-protein kinase ULK1. (973 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
C9orf72Uncharacterized protein. (481 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1649 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
CTSVCathepsin L1; Belongs to the peptidase C1 family. (334 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (404 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATG2BAutophagy-related protein 2-like protein B. (2078 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
RRASRas-related protein R-Ras. (218 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
DAPK2Protein kinase domain-containing protein. (488 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TSC1Hamartin. (1159 aa)
ATG4DAutophagy related 4D cysteine peptidase. (432 aa)
VMP1Transmembrane protein 49. (406 aa)
AKT1S1Proline-rich AKT1 substrate 1. (349 aa)
RRAGCRas-related GTP-binding protein C. (389 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2. (142 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
NRBF2Nuclear receptor-binding factor 2. (288 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
STX17Syntaxin-17; Belongs to the syntaxin family. (302 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
MRASRas-related protein M-Ras. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
RAB39BRas-related protein Rab-39B. (213 aa)
RUBCNRun domain Beclin-1 interacting and cystein-rich containing protein. (971 aa)
ATG2AAutophagy-related protein 2. (1927 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (711 aa)
ATG10Ubiquitin-like-conjugating enzyme ATG10. (234 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
RRAGBRas-related GTP-binding protein B-like. (371 aa)
ATG101Autophagy-related protein 101. (218 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (956 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
RAB8ARAB8A, member RAS oncogene family. (256 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (552 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1. (788 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
ATG3Autophagy-related protein 3. (314 aa)
WDR41WD repeat-containing protein 41. (482 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
RAB33BRas-related protein Rab-33B. (229 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
MTMR14Myotubularin-related protein 14. (649 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC102271380Uncharacterized protein. (174 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (427 aa)
RB1CC1RB1-inducible coiled-coil protein 1. (1589 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
SUPT20HProtein FAM48A. (817 aa)
RAB7ARas-related protein Rab-7a. (247 aa)
BADBcl2 antagonist of cell death. (168 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (145 aa)
ULK2Serine/threonine-protein kinase ULK2. (952 aa)
SQSTM1Sequestosome-1. (356 aa)
BECN2Beclin-1-like protein 1. (439 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
BECN1Beclin-1. (448 aa)
SMCR8Smith-Magenis syndrome chromosomal region candidate 8 protein. (934 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
IGBP1Immunoglobulin binding protein 1. (338 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
TANKTRAF family member-associated NF-kappa-B activator. (422 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
SH3GLB1Endophilin-B1. (394 aa)
TSC2Tuberous sclerosis 2. (1812 aa)
RAB7BRas-related protein Rab-7b. (197 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
DAPK1Death-associated protein kinase 1. (1430 aa)
CTSLCathepsin L1; Belongs to the peptidase C1 family. (330 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (579 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
SNAP29Synaptosomal-associated protein 29. (258 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (418 aa)
KRASGTPase KRas. (189 aa)
RAB1ARas-related protein Rab-1A. (205 aa)
IRS4Insulin receptor substrate 4. (1207 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
MTMR4Myotubularin-related protein 4. (1197 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2. (455 aa)
RRAGDRas-related GTP-binding protein D. (397 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
LAMP2Lysosome-associated membrane glycoprotein 2. (452 aa)
HMGB1High mobility group protein B1. (215 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (350 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1. (1297 aa)
ATG13Autophagy-related protein 13. (553 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
UVRAGUV radiation resistance-associated protein. (699 aa)
TBK1Serine/threonine-protein kinase TBK1. (875 aa)
ATG16L1Autophagy-related protein 16-1. (623 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
MTMR3Myotubularin-related protein 3/4. (1195 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (447 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (511 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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