STRINGSTRING
ULK1 ULK1 GSK3B GSK3B TTI1 TTI1 IKBKB IKBKB MTOR MTOR ATP6V1B1 ATP6V1B1 WNT3 WNT3 LPIN2 LPIN2 CAB39L CAB39L WNT11 WNT11 WNT2B WNT2B ATP6V1B2 ATP6V1B2 LAMTOR5 LAMTOR5 WNT8B WNT8B STK11 STK11 IGF1R IGF1R TSC1 TSC1 AKT1S1 AKT1S1 RRAGC RRAGC ATP6V1E2 ATP6V1E2 LRP5L LRP5L RPS6KB1 RPS6KB1 EIF4E2 EIF4E2 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 MIOS MIOS EIF4EBP1 EIF4EBP1 SEC13 SEC13 PTEN PTEN TNFRSF1A TNFRSF1A NRAS NRAS STRADA STRADA PIK3CB PIK3CB FZD9 FZD9 M91_02843 M91_02843 RRAGB RRAGB SGK1 SGK1 ATP6V1E1 ATP6V1E1 LAMTOR3 LAMTOR3 GRB2 GRB2 ATP6V1D ATP6V1D PRKAA2 PRKAA2 LRP6 LRP6 PIK3R1 PIK3R1 IGF1 IGF1 FZD5 FZD5 SEH1L SEH1L FZD3 FZD3 RAF1 RAF1 LOC102264736 LOC102264736 CASTOR2 CASTOR2 FZD1 FZD1 WNT3A WNT3A ATP6V1H ATP6V1H IRS1 IRS1 ATP6V1G2 ATP6V1G2 TNF TNF SLC7A5 SLC7A5 LAMTOR2 LAMTOR2 WNT2 WNT2 RHOA RHOA ULK2 ULK2 RICTOR RICTOR PDPK1 PDPK1 RRAGA RRAGA RPS6 RPS6 FNIP1 FNIP1 ATP6V1G1 ATP6V1G1 MLST8 MLST8 ATP6V1G3 ATP6V1G3 ATP6V1A ATP6V1A AKT2 AKT2 FLCN FLCN RPS6KA1 RPS6KA1 PIK3CA PIK3CA STRADB STRADB WNT7A WNT7A RPS6KA3 RPS6KA3 DDIT4 DDIT4 TSC2 TSC2 SESN2 SESN2 LAMTOR1 LAMTOR1 FZD7 FZD7 CHUK CHUK EIF4E EIF4E SKP2 SKP2 RPTOR RPTOR ATP6V1C2 ATP6V1C2 MAP2K2 MAP2K2 PIK3R3 PIK3R3 FZD4 FZD4 MAPKAP1 MAPKAP1 KRAS KRAS FZD2 FZD2 NPRL2 NPRL2 RRAGD RRAGD SOS2 SOS2 RPS6KB2 RPS6KB2 TELO2 TELO2 WDR59 WDR59 ENSBMUP00000030233 ENSBMUP00000030233 ENSBMUP00000030236 ENSBMUP00000030236 EIF4B EIF4B WNT1 WNT1 ATP6V1F ATP6V1F SLC38A9 SLC38A9 SLC3A2 SLC3A2 DEPDC5 DEPDC5 WDR24 WDR24 FZD10 FZD10 DVL1 DVL1 WNT16 WNT16 NPRL3 NPRL3 PRKCG PRKCG FNIP2 FNIP2 TBC1D7 TBC1D7 PRKCA PRKCA PIK3R2 PIK3R2 WNT8A WNT8A WNT10A WNT10A INSR INSR FZD6 FZD6 ATP6V1C1 ATP6V1C1 CAB39 CAB39 DEPTOR DEPTOR PRKAA1 PRKAA1 MAPK3 MAPK3 AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ULK1Serine/threonine-protein kinase ULK1. (973 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
TTI1TEL2-interacting protein 1-like protein. (1092 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LPIN2Phosphatidate phosphatase LPIN2. (922 aa)
CAB39LCalcium-binding protein 39-like protein. (334 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
LAMTOR5Hepatitis B virus X-interacting protein-like protein. (91 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TSC1Hamartin. (1159 aa)
AKT1S1Proline-rich AKT1 substrate 1. (349 aa)
RRAGCRas-related GTP-binding protein C. (389 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
LRP5LLow-density lipoprotein receptor-related protein 5. (251 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (238 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
MIOSWD repeat-containing protein mio. (875 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
SEC13Protein SEC13-like protein; Belongs to the WD repeat SEC13 family. (325 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
NRASGTPase NRas. (189 aa)
STRADASTE20-related kinase adapter protein alpha. (403 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
RRAGBRas-related GTP-binding protein B-like. (371 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
LAMTOR3Mitogen-activated protein kinase scaffold protein 1. (124 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1613 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
FZD5Frizzled class receptor 5. (545 aa)
SEH1LNucleoporin SEH1; Belongs to the WD repeat SEC13 family. (356 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
LOC102264736Growth factor receptor-bound protein 10. (562 aa)
CASTOR2GATS-like protein 2. (378 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (650 aa)
WNT3AWingless-type MMTV integration site family, member 3. (348 aa)
ATP6V1HV-type H+-transporting ATPase subunit H. (483 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (136 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (507 aa)
LAMTOR2Mitogen-activated protein-binding protein-interacting protein. (125 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RHOATransforming protein RhoA. (193 aa)
ULK2Serine/threonine-protein kinase ULK2. (952 aa)
RICTORRapamycin-insensitive companion of mTOR. (1737 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
RPS640S ribosomal protein S6. (249 aa)
FNIP1Folliculin-interacting protein 1. (1163 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FLCNFolliculin. (579 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
STRADBSTE20-related kinase adapter protein beta. (418 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (712 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
TSC2Tuberous sclerosis 2. (1812 aa)
SESN2Sestrin-2. (471 aa)
LAMTOR1Uncharacterized protein. (161 aa)
FZD7Frizzled class receptor 7. (558 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
SKP2S-phase kinase-associated protein 2. (408 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (522 aa)
KRASGTPase KRas. (189 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (515 aa)
NPRL2Nitrogen permease regulator 2-like protein. (380 aa)
RRAGDRas-related GTP-binding protein D. (397 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
TELO2Telomere length regulation protein TEL2-like protein. (822 aa)
WDR59WD repeat-containing protein 59. (973 aa)
ENSBMUP00000030233Wingless-type MMTV integration site family, member 7. (190 aa)
ENSBMUP00000030236Wingless-type MMTV integration site family, member 7. (154 aa)
EIF4BEukaryotic translation initiation factor 4B. (615 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
SLC38A9Solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9. (560 aa)
SLC3A24F2 cell-surface antigen heavy chain. (572 aa)
DEPDC5DEP domain-containing protein 5. (1598 aa)
WDR24WD repeat-containing protein 24. (790 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
DVL1Segment polarity protein dishevelled-like protein DVL-1. (691 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
NPRL3Nitrogen permease regulator 3-like protein. (569 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
FNIP2Folliculin-interacting protein 2. (1110 aa)
TBC1D7TBC1 domain family member 7. (292 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10AWingless-type MMTV integration site family, member 10. (393 aa)
INSRInsulin receptor. (1382 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
CAB39Calcium-binding protein 39. (341 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (447 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
Server load: low (16%) [HD]