STRINGSTRING
CCNA2 CCNA2 ULK1 ULK1 PPP2R3B PPP2R3B MTOR MTOR PFKFB3 PFKFB3 PFKFB1 PFKFB1 CAB39L CAB39L PFKM PFKM PPP2CA PPP2CA LEP LEP HNF4A HNF4A PPP2R3C PPP2R3C G6PC2 G6PC2 PFKP PFKP STK11 STK11 PPP2R3A PPP2R3A IGF1R IGF1R TSC1 TSC1 CPT1C CPT1C AKT1S1 AKT1S1 RPS6KB1 RPS6KB1 ADIPOR1 ADIPOR1 ACACA ACACA CPT1A CPT1A CCND1 CCND1 PPP2R5A PPP2R5A EIF4EBP1 EIF4EBP1 STRADA STRADA PIK3CB PIK3CB SLC2A4 SLC2A4 RAB10 RAB10 PPP2R5B PPP2R5B LIPE LIPE PPP2R2B PPP2R2B M91_02843 M91_02843 PRKAG2 PRKAG2 ADIPOR2 ADIPOR2 PPARGC1A PPARGC1A PRKAA2 PRKAA2 PRKAB2 PRKAB2 RAB8A RAB8A PIK3R1 PIK3R1 ENSBMUP00000013050 ENSBMUP00000013050 IGF1 IGF1 CREB1 CREB1 LOC102278265 LOC102278265 FBP1 FBP1 PPARG PPARG HMGCR HMGCR RAB2A RAB2A PPP2R5D PPP2R5D PFKL PFKL IRS1 IRS1 PPP2R1B PPP2R1B CCNA1 CCNA1 PPP2R5E PPP2R5E CFTR CFTR PPP2R5C PPP2R5C PDPK1 PDPK1 CREB3L2 CREB3L2 GYS1 GYS1 AKT2 AKT2 M91_13196 M91_13196 PPP2R2A PPP2R2A RAB14 RAB14 ADRA1A ADRA1A PIK3CA PIK3CA CPT1B CPT1B MAP3K7 MAP3K7 PPP2CB PPP2CB ENSBMUP00000022382 ENSBMUP00000022382 LEPR LEPR PCK1 PCK1 STRADB STRADB SCD SCD LOC102266138 LOC102266138 TSC2 TSC2 FOXO1 FOXO1 RPTOR RPTOR ADIPOQ ADIPOQ EEF2 EEF2 CAMKK2 CAMKK2 CREB3L3 CREB3L3 PIK3R3 PIK3R3 G6PC3 G6PC3 FOXO3 FOXO3 G6PC G6PC CREB5 CREB5 TBC1D1 TBC1D1 IRS4 IRS4 PPP2R2C PPP2R2C SCD5 SCD5 RPS6KB2 RPS6KB2 PRKAB1 PRKAB1 ACACB ACACB CREB3L1 CREB3L1 SIRT1 SIRT1 PRKAG1 PRKAG1 CREB3 CREB3 PCK2 PCK2 PFKFB2 PFKFB2 MLYCD MLYCD PIK3R2 PIK3R2 RAB11B RAB11B ELAVL1 ELAVL1 PRKAG3 PRKAG3 INSR INSR CAB39 CAB39 PRKAA1 PRKAA1 FASN FASN AKT1 AKT1 CRTC2 CRTC2 CREB3L4 CREB3L4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNA2Cyclin-A2; Belongs to the cyclin family. (417 aa)
ULK1Serine/threonine-protein kinase ULK1. (973 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B. (540 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. (534 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. (244 aa)
CAB39LCalcium-binding protein 39-like protein. (334 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
G6PC2Glucose-6-phosphatase 2. (355 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (783 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1150 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TSC1Hamartin. (1159 aa)
CPT1CCarnitine O-palmitoyltransferase 1, brain isoform; Belongs to the carnitine/choline acetyltransferase family. (779 aa)
AKT1S1Proline-rich AKT1 substrate 1. (349 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
ACACAAcetyl-CoA carboxylase / biotin carboxylase 1. (2383 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform. (429 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
STRADASTE20-related kinase adapter protein alpha. (403 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
RAB10Ras-related protein Rab-10. (200 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform. (545 aa)
LIPEHormone-sensitive lipase. (799 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (317 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (796 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
RAB8ARAB8A, member RAS oncogene family. (256 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
ENSBMUP00000013050Fructose-1,6-bisphosphatase isozyme 2-like. (57 aa)
IGF1Insulin-like growth factor I. (194 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
LOC102278265Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (530 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
RAB2ARas-related protein Rab-2A. (203 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform. (604 aa)
PFKL6-phosphofructokinase, liver type. (751 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (667 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A regulatory subunit B. (467 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1189 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform. (462 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (736 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
M91_13196Uncharacterized protein. (663 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
RAB14Ras-related protein Rab-14. (215 aa)
ADRA1AAlpha-1A adrenergic receptor. (455 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform; Belongs to the carnitine/choline acetyltransferase family. (771 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
LEPRLeptin receptor. (1165 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
STRADBSTE20-related kinase adapter protein beta. (418 aa)
SCDAcyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
LOC102266138Uncharacterized protein; Belongs to the CD36 family. (472 aa)
TSC2Tuberous sclerosis 2. (1812 aa)
FOXO1Forkhead box protein O1. (468 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
ADIPOQAdiponectin. (246 aa)
EEF2Elongation factor 2. (858 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (579 aa)
CREB3L3CAMP responsive element binding protein 3 like 3. (456 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
G6PC3Glucose-6-phosphatase 3. (453 aa)
FOXO3Forkhead box protein O3. (453 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (356 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
TBC1D1TBC1 domain family member 1. (887 aa)
IRS4Insulin receptor substrate 4. (1207 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (482 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (270 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (297 aa)
ACACBAcetyl-CoA carboxylase / biotin carboxylase 2. (2240 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (454 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (349 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2. (535 aa)
MLYCDMalonyl-CoA decarboxylase, mitochondrial. (494 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (496 aa)
INSRInsulin receptor. (1382 aa)
CAB39Calcium-binding protein 39. (341 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
FASNFatty acid synthase, animal type. (2492 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
CRTC2CREB-regulated transcription coactivator 2. (693 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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