STRINGSTRING
CCNA2 CCNA2 RRAS2 RRAS2 GADD45G GADD45G VDAC3 VDAC3 RBL1 RBL1 MTOR MTOR RELA RELA RB1 RB1 CXCL8 CXCL8 GATA4 GATA4 VDAC1 VDAC1 CCNE2 CCNE2 LOC102278231 LOC102278231 CAPN1 CAPN1 NFATC3 NFATC3 RAD1 RAD1 BTRC BTRC HIPK1 HIPK1 CCNB3 CCNB3 RRAS RRAS E2F4 E2F4 TSC1 TSC1 MRE11 MRE11 CALM3 CALM3 M91_10145 M91_10145 CCND1 CCND1 MAP2K1 MAP2K1 CCNB2 CCNB2 SMAD3 SMAD3 SERPINE1 SERPINE1 HRAS HRAS HUS1 HUS1 EIF4EBP1 EIF4EBP1 IGFBP3 IGFBP3 TGFBR1 TGFBR1 PTEN PTEN CALML4 CALML4 NRAS NRAS CCNE1 CCNE1 MRAS MRAS CDK1 CDK1 PIK3CB PIK3CB CAPN2 CAPN2 CALML5 CALML5 SMAD2 SMAD2 M91_10368 M91_10368 LOC102272326 LOC102272326 IL1A IL1A MYC MYC NFATC4 NFATC4 M91_02843 M91_02843 HIPK3 HIPK3 LIN52 LIN52 TGFB2 TGFB2 RBBP4 RBBP4 M91_13835 M91_13835 PIK3R1 PIK3R1 SLC25A5 SLC25A5 GADD45A GADD45A NBN NBN RBL2 RBL2 TRPM7 TRPM7 SLC25A4 SLC25A4 RAF1 RAF1 MDM2 MDM2 CDC25A CDC25A CDKN2A CDKN2A CALM1 CALM1 CDKN1A CDKN1A PPP1CB PPP1CB ZFP36L1 ZFP36L1 E2F3 E2F3 MAPK13 MAPK13 MAPK14 MAPK14 CDK6 CDK6 GADD45B GADD45B LOC102286220 LOC102286220 CCNA1 CCNA1 PPP3CC PPP3CC CCND3 CCND3 RAD50 RAD50 SQSTM1 SQSTM1 MYBL2 MYBL2 E2F5 E2F5 PPP3CA PPP3CA LIN9 LIN9 VDAC2 VDAC2 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 HIPK4 HIPK4 ITPR1 ITPR1 PPID PPID TGFBR2 TGFBR2 MAP2K3 MAP2K3 LOC102287375 LOC102287375 PIK3CA PIK3CA M91_20047 M91_20047 HIPK2 HIPK2 TRAF3IP2 TRAF3IP2 MCU MCU LIN37 LIN37 TSC2 TSC2 FBXW11 FBXW11 FOXO1 FOXO1 FOXM1 FOXM1 LOC102288356 LOC102288356 LOC102285474 LOC102285474 MAP2K2 MAP2K2 PIK3R3 PIK3R3 FOXO3 FOXO3 NFKB1 NFKB1 KRAS KRAS PPP3R1 PPP3R1 ATR ATR RAD9B RAD9B LIN54 LIN54 PPP1CC PPP1CC PPP1CA PPP1CA TP53 TP53 IL6 IL6 TRPV4 TRPV4 SLC25A6 SLC25A6 SLC25A31 SLC25A31 ITPR2 ITPR2 LOC102266500 LOC102266500 SIRT1 SIRT1 MAP2K6 MAP2K6 LOC102280361 LOC102280361 TGFB1 TGFB1 CCNB1 CCNB1 E2F1 E2F1 CACNA1D CACNA1D MAPKAPK2 MAPKAPK2 RASSF5 RASSF5 CDK4 CDK4 PIK3R2 PIK3R2 CCND2 CCND2 MAPK3 MAPK3 AKT1 AKT1 M91_12975 M91_12975 PPP3CB PPP3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNA2Cyclin-A2; Belongs to the cyclin family. (417 aa)
RRAS2Ras-related protein R-Ras2. (173 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (284 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
RELATranscription factor p65. (549 aa)
RB1Retinoblastoma-associated protein. (880 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
GATA4Transcription factor GATA-4. (236 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
LOC102278231BOLA class I histocompatibility antigen, alpha chain BL3-7-like. (240 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (716 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1038 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
BTRCF-box/WD repeat-containing protein 1A. (605 aa)
HIPK1Homeodomain-interacting protein kinase 1; Belongs to the protein kinase superfamily. (1242 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1307 aa)
RRASRas-related protein R-Ras. (218 aa)
E2F4Transcription factor E2F4. (404 aa)
TSC1Hamartin. (1159 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
M91_10145Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (290 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
IGFBP3Insulin like growth factor binding protein 3. (289 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CALML4Calmodulin-like protein 4. (197 aa)
NRASGTPase NRas. (189 aa)
CCNE1G1/S-specific cyclin-E1. (411 aa)
MRASRas-related protein M-Ras. (208 aa)
CDK1Cell division protein kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (700 aa)
CALML5Calmodulin. (148 aa)
SMAD2Mothers against decapentaplegic homolog. (468 aa)
M91_10368Ig-like domain-containing protein; Belongs to the MHC class I family. (377 aa)
LOC102272326Ig-like domain-containing protein; Belongs to the MHC class I family. (353 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
HIPK3Homeodomain-interacting protein kinase 3. (1231 aa)
LIN52Protein lin-52-like protein. (116 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RBBP4Histone-binding protein RBBP4. (425 aa)
M91_13835Serine-protein kinase ATM. (319 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
NBNNibrin. (754 aa)
RBL2Retinoblastoma-like protein 2. (1140 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
CDC25AM-phase inducer phosphatase 1. (525 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoform 4. (153 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1. (338 aa)
E2F3Transcription factor E2F3. (334 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
CDK6Cell division protein kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
LOC102286220BOLA class I histocompatibility antigen, alpha chain BL3-6; Belongs to the MHC class I family. (480 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (292 aa)
RAD50DNA repair protein RAD50. (1311 aa)
SQSTM1Sequestosome-1. (356 aa)
MYBL2Myb-related protein B. (690 aa)
E2F5Transcription factor E2F4/5. (185 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LIN9Protein lin-9-like protein. (558 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (294 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HIPK4Homeodomain-interacting protein kinase 4. (616 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (370 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC102287375Calmodulin. (149 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
M91_20047Ig-like domain-containing protein. (272 aa)
HIPK2Homeodomain-interacting protein kinase 2. (1311 aa)
TRAF3IP2Adapter protein CIKS. (563 aa)
MCUCoiled-coil domain-containing protein 109A. (314 aa)
LIN37Protein lin-37-like protein. (246 aa)
TSC2Tuberous sclerosis 2. (1812 aa)
FBXW11F-box/WD repeat-containing protein 11. (531 aa)
FOXO1Forkhead box protein O1. (468 aa)
FOXM1Forkhead box protein M1. (761 aa)
LOC102288356Ig-like domain-containing protein; Belongs to the MHC class I family. (337 aa)
LOC102285474Nuclear factor of activated T-cells, cytoplasmic 1-like. (454 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FOXO3Forkhead box protein O3. (453 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
KRASGTPase KRas. (189 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (328 aa)
LIN54Protein lin-54-like protein. (771 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
IL6Interleukin-6. (254 aa)
TRPV4Transient receptor putative cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
SLC25A6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (278 aa)
SLC25A31Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
LOC102266500Serine/threonine-protein kinase Chk1. (256 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (454 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC102280361Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
E2F1E2F transcription factor 1. (360 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RASSF5Ras association domain-containing protein 5. (406 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (284 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
M91_12975Ig-like domain-containing protein. (341 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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