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GSK3B GSK3B DCC DCC SRC SRC PAK6 PAK6 GNAI1 GNAI1 CFL1 CFL1 MYL9 MYL9 PDK1 PDK1 MYL12A MYL12A PAK3 PAK3 TRPC5 TRPC5 LRRC4 LRRC4 PARD3 PARD3 PAK5 PAK5 NFATC3 NFATC3 SEMA4G SEMA4G PARD6A PARD6A GNAI3 GNAI3 EPHB6 EPHB6 NCK1 NCK1 CDK5 CDK5 CFL2 CFL2 EFNA2 EFNA2 RRAS RRAS EPHA2 EPHA2 SLIT3 SLIT3 NTNG2 NTNG2 RYK RYK EPHB1 EPHB1 UNC5C UNC5C PLXNC1 PLXNC1 BMPR1B BMPR1B HRAS HRAS NRAS NRAS PIK3CB PIK3CB CXCL12 CXCL12 SEMA4B SEMA4B SEMA3A SEMA3A FES FES SEMA3D SEMA3D SEMA3G SEMA3G NCK2 NCK2 SLIT2 SLIT2 NFATC4 NFATC4 DPYSL5 DPYSL5 SEMA4D SEMA4D PTPN11 PTPN11 SSH2 SSH2 ARHGEF12 ARHGEF12 BOC BOC PIK3R1 PIK3R1 PLXNA2 PLXNA2 FZD3 FZD3 RAF1 RAF1 ROBO1 ROBO1 ROBO2 ROBO2 PARD6B PARD6B PLXNB1 PLXNB1 SRGAP3 SRGAP3 CAMK2A CAMK2A EPHA5 EPHA5 EFNA4 EFNA4 EFNA3 EFNA3 EFNA1 EFNA1 PLXNB3 PLXNB3 L1CAM L1CAM NEO1 NEO1 ILK ILK EPHA7 EPHA7 PTK2 PTK2 ENSBMUP00000017372 ENSBMUP00000017372 SEMA4F SEMA4F EPHA1 EPHA1 PPP3CC PPP3CC MET MET SEMA5B SEMA5B RHOA RHOA SEMA4A SEMA4A EFNA5 EFNA5 TRPC4 TRPC4 TRPC6 TRPC6 ABLIM3 ABLIM3 PAK4 PAK4 SEMA7A SEMA7A NTN3 NTN3 EPHB2 EPHB2 EPHA8 EPHA8 PPP3CA PPP3CA CDC42 CDC42 LOC102270098 LOC102270098 PTCH1 PTCH1 NRP1 NRP1 ITGB1 ITGB1 EPHA3 EPHA3 TRPC3 TRPC3 EFNB1 EFNB1 RASA1 RASA1 DPYSL2 DPYSL2 BMP7 BMP7 PIK3CA PIK3CA FYN FYN SHH SHH PLXNB2 PLXNB2 SEMA3C SEMA3C ROCK2 ROCK2 BMPR2 BMPR2 ROBO3 ROBO3 SEMA3E SEMA3E PARD6G PARD6G EPHA4 EPHA4 UNC5A UNC5A EPHB4 EPHB4 PIK3R3 PIK3R3 NTN4 NTN4 EPHB3 EPHB3 SEMA6B SEMA6B SEMA6A SEMA6A LRRC4C LRRC4C CXCR4 CXCR4 KRAS KRAS PPP3R1 PPP3R1 TRPC1 TRPC1 PLCG2 PLCG2 SLIT1 SLIT1 UNC5D UNC5D SSH1 SSH1 RHOD RHOD SSH3 SSH3 SEMA3F SEMA3F PAK2 PAK2 GNAI2 GNAI2 SEMA3B SEMA3B EFNB3 EFNB3 SEMA6D SEMA6D ROCK1 ROCK1 RND1 RND1 RGS3 RGS3 SMO SMO PRKCZ PRKCZ PAK1 PAK1 LIMK2 LIMK2 RAC2 RAC2 SRGAP1 SRGAP1 NGEF NGEF SEMA4C SEMA4C SRGAP2 SRGAP2 PRKCA PRKCA PIK3R2 PIK3R2 MAPK3 MAPK3 PLCG1 PLCG1 UNC5B UNC5B PPP3CB PPP3CB PLXNA3 PLXNA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
DCCNetrin receptor DCC. (1446 aa)
SRCTyrosine-protein kinase. (559 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha. (354 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (205 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
PDK1Protein-serine/threonine kinase. (437 aa)
MYL12AMyosin regulatory light chain 12A. (178 aa)
PAK3Serine/threonine-protein kinase PAK 3. (580 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5. (971 aa)
LRRC4Leucine rich repeat containing 4. (685 aa)
PARD3Partitioning defective 3-like protein. (1029 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1038 aa)
SEMA4GSemaphorin-4G; Belongs to the semaphorin family. (844 aa)
PARD6APartitioning defective 6-like protein alpha. (344 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
EPHB6EPH receptor B6. (722 aa)
NCK1Cytoplasmic protein NCK1. (377 aa)
CDK5Cell division protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
EFNA2Ephrin-A2; Belongs to the ephrin family. (203 aa)
RRASRas-related protein R-Ras. (218 aa)
EPHA2EPH receptor A2. (975 aa)
SLIT3Slit-like protein 3 protein. (1523 aa)
NTNG2Netrin-G2. (399 aa)
RYKTyrosine-protein kinase RYK. (607 aa)
EPHB1Ephrin type-B receptor 1. (545 aa)
UNC5CNetrin receptor UNC5C. (889 aa)
PLXNC1Plexin-C1. (614 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CXCL12C-X-C motif chemokine ligand 12. (119 aa)
SEMA4BSemaphorin 4B. (832 aa)
SEMA3ASemaphorin-3A; Belongs to the semaphorin family. (800 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (814 aa)
SEMA3DSemaphorin-3D; Belongs to the semaphorin family. (776 aa)
SEMA3GSemaphorin-3G; Belongs to the semaphorin family. (770 aa)
NCK2Cytoplasmic protein. (376 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
DPYSL5Dihydropyrimidinase like 5. (564 aa)
SEMA4DSemaphorin-4D; Belongs to the semaphorin family. (863 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
SSH2Protein phosphatase Slingshot-like protein 2. (1431 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1549 aa)
BOCBrother of CDO. (1116 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
PLXNA2Plexin-A2. (1890 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
ROBO1Roundabout-like protein 1. (1620 aa)
ROBO2Roundabout-like protein 2. (1309 aa)
PARD6BPartitioning defective 6-like protein beta. (351 aa)
PLXNB1Plexin-B1. (2133 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
EPHA5Ephrin type-A receptor 5. (1031 aa)
EFNA4Ephrin-A4; Belongs to the ephrin family. (326 aa)
EFNA3Ephrin-A3; Belongs to the ephrin family. (238 aa)
EFNA1Ephrin-A1; Belongs to the ephrin family. (317 aa)
PLXNB3Plexin-B3. (1902 aa)
L1CAMNeural cell adhesion molecule L1. (1257 aa)
NEO1Neogenin. (1461 aa)
ILKIntegrin-linked protein kinase. (452 aa)
EPHA7Ephrin type-A receptor 7. (998 aa)
PTK2Focal adhesion kinase 1. (1065 aa)
ENSBMUP00000017372Plexin-A4. (476 aa)
SEMA4FSemaphorin-4F; Belongs to the semaphorin family. (770 aa)
EPHA1Ephrin type-A receptor 1. (980 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
METHepatocyte growth factor receptor. (1384 aa)
SEMA5BSemaphorin-5B. (1075 aa)
RHOATransforming protein RhoA. (193 aa)
SEMA4ASemaphorin-4A; Belongs to the semaphorin family. (762 aa)
EFNA5Ephrin-A5; Belongs to the ephrin family. (188 aa)
TRPC4Short transient receptor putative channel 4; Belongs to the transient receptor (TC 1.A.4) family. (981 aa)
TRPC6Short transient receptor putative channel 6. (932 aa)
ABLIM3Actin-binding LIM protein 3. (683 aa)
PAK4P21 (RAC1) activated kinase 4. (303 aa)
SEMA7ASemaphorin-7A. (501 aa)
NTN3Netrin-3. (826 aa)
EPHB2EPH receptor B2. (995 aa)
EPHA8Ephrin type-A receptor 8. (1005 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
LOC102270098Ephrin type-A receptor 6-like. (544 aa)
PTCH1Protein patched-like protein 1. (1459 aa)
NRP1Neuropilin-1. (923 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (814 aa)
EPHA3Ephrin type-A receptor 3. (984 aa)
TRPC3Short transient receptor putative channel 3. (921 aa)
EFNB1Ephrin-B1; Belongs to the ephrin family. (346 aa)
RASA1Ras GTPase-activating protein 1. (1048 aa)
DPYSL2Dihydropyrimidinase-related protein 2. (677 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FYNTyrosine-protein kinase. (537 aa)
SHHSonic hedgehog protein. (453 aa)
PLXNB2Plexin B2. (1759 aa)
SEMA3CSemaphorin-3C. (751 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1297 aa)
BMPR2Bone morphogenetic protein receptor type 2. (1038 aa)
ROBO3Roundabout, axon guidance receptor 3. (1383 aa)
SEMA3ESemaphorin-3E. (736 aa)
PARD6GPartitioning defective 6-like protein gamma. (371 aa)
EPHA4Ephrin type-A receptor 4. (986 aa)
UNC5ANetrin receptor UNC5A. (878 aa)
EPHB4Ephrin type-B receptor 4. (987 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
NTN4Netrin-4. (628 aa)
EPHB3Ephrin type-B receptor 3. (998 aa)
SEMA6BSemaphorin-6B. (869 aa)
SEMA6ASemaphorin-6A; Belongs to the semaphorin family. (1046 aa)
LRRC4CLeucine-rich repeat-containing protein 4C. (648 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
KRASGTPase KRas. (189 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
TRPC1Short transient receptor putative channel 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
SLIT1Slit-like protein 1 protein. (1396 aa)
UNC5DNetrin receptor UNC5D. (959 aa)
SSH1Protein phosphatase Slingshot-like protein 1. (1010 aa)
RHODRho-related GTP-binding protein RhoD. (210 aa)
SSH3Protein phosphatase Slingshot-like protein 3. (648 aa)
SEMA3FSemaphorin-3F; Belongs to the semaphorin family. (792 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
SEMA3BSemaphorin-3B; Belongs to the semaphorin family. (749 aa)
EFNB3Ephrin-B3; Belongs to the ephrin family. (340 aa)
SEMA6DSemaphorin 6D. (1073 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RND1Rho-related GTP-binding protein Rho6. (232 aa)
RGS3Regulator of G-protein signaling 3. (1147 aa)
SMOSmoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
PRKCZProtein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (592 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
LIMK2LIM domain kinase 2. (658 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
SRGAP1SLIT-ROBO Rho GTPase-activating protein 1. (1085 aa)
NGEFNeuronal guanine nucleotide exchange factor. (668 aa)
SEMA4CSemaphorin-4C; Belongs to the semaphorin family. (831 aa)
SRGAP2SLIT-ROBO Rho GTPase activating protein 2. (1069 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
UNC5BNetrin receptor UNC5B. (945 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PLXNA3Plexin-A3. (1871 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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