STRINGSTRING
TAB1 TAB1 IKBKB IKBKB FOSL1 FOSL1 TRAF2 TRAF2 RELA RELA MAP3K14 MAP3K14 LOC102280754 LOC102280754 NFKB2 NFKB2 FHL2 FHL2 JAK1 JAK1 TNFSF11 TNFSF11 CSF1 CSF1 NFKBIA NFKBIA CALCR CALCR MAP2K1 MAP2K1 TGFBR1 TGFBR1 TNFRSF1A TNFRSF1A LOC102280497 LOC102280497 LOC102282466 LOC102282466 LOC102281065 LOC102281065 PIK3CB PIK3CB FOS FOS IL1R1 IL1R1 IL1A IL1A IL1B IL1B IFNAR2 IFNAR2 IFNAR1 IFNAR1 IFNGR2 IFNGR2 TGFB2 TGFB2 GRB2 GRB2 TRAF6 TRAF6 SOCS3 SOCS3 LOC102273069 LOC102273069 LOC102273538 LOC102273538 PIK3R1 PIK3R1 SYK SYK CREB1 CREB1 NOX1 NOX1 PPARG PPARG LCP2 LCP2 BTK BTK NCF1 NCF1 IFNG IFNG MITF MITF MAPK9 MAPK9 IFNGR1 IFNGR1 GAB2 GAB2 FOSL2 FOSL2 MAPK13 MAPK13 MAPK14 MAPK14 TAB2 TAB2 CYBA CYBA TYK2 TYK2 TNF TNF PPP3CC PPP3CC SQSTM1 SQSTM1 PPP3CA PPP3CA CSF1R CSF1R MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 STAT1 STAT1 TGFBR2 TGFBR2 TNFRSF11B TNFRSF11B PIK3CA PIK3CA MAP3K7 MAP3K7 FYN FYN TYROBP TYROBP CHUK CHUK STAT2 STAT2 LOC102285474 LOC102285474 PIK3R3 PIK3R3 NFKB1 NFKB1 RELB-2 RELB-2 MAPK8 MAPK8 PPP3R1 PPP3R1 FOSB FOSB PLCG2 PLCG2 NCF2 NCF2 MAPK10 MAPK10 SIRPA SIRPA LOC102285099 LOC102285099 LOC102285368 LOC102285368 MAP2K6 MAP2K6 TGFB1 TGFB1 CTSK CTSK TREM2 TREM2 SPI1 SPI1 LOC102284581 LOC102284581 NCF4 NCF4 IRF9 IRF9 ITGB3 ITGB3 CAMK4 CAMK4 PIK3R2 PIK3R2 CYLD CYLD MAP2K7 MAP2K7 ACP5 ACP5 MAPK3 MAPK3 AKT1 AKT1 PPP3CB PPP3CB IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (267 aa)
TRAF2TNF receptor associated factor 2. (311 aa)
RELATranscription factor p65. (549 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
LOC102280754High affinity immunoglobulin gamma Fc receptor I. (349 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
FHL2Four and a half LIM domains protein 2. (279 aa)
JAK1Janus kinase 1. (1158 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (244 aa)
CSF1Macrophage colony-stimulating factor 1. (545 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (478 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
LOC102280497Interferon beta-3. (182 aa)
LOC102282466Interferon beta-2. (187 aa)
LOC102281065Uncharacterized protein. (186 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IFNAR2Interferon alpha/beta receptor 2. (488 aa)
IFNAR1Interferon alpha/beta receptor 1. (536 aa)
IFNGR2Interferon gamma receptor 2. (363 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
LOC102273069Uncharacterized protein. (312 aa)
LOC102273538Low affinity immunoglobulin gamma Fc region receptor III. (250 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SYKNon-specific protein-tyrosine kinase. (629 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
NOX1NADPH oxidase 1. (561 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (530 aa)
LCP2Lymphocyte cytosolic protein 2. (530 aa)
BTKTyrosine-protein kinase. (659 aa)
NCF1Neutrophil cytosol factor 1. (392 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
MITFMicrophthalmia-associated transcription factor. (520 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
GAB2GRB2-associated-binding protein 2. (666 aa)
FOSL2Fos-related antigen 2. (313 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2. (409 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
TYK2Non-specific protein-tyrosine kinase. (1187 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
SQSTM1Sequestosome-1. (356 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (958 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT1Signal transducer and activator of transcription. (817 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
FYNTyrosine-protein kinase. (537 aa)
TYROBPTYRO protein tyrosine kinase-binding protein. (158 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
STAT2Signal transducer and activator of transcription. (857 aa)
LOC102285474Nuclear factor of activated T-cells, cytoplasmic 1-like. (454 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
RELB-2RELB proto-oncogene, NF-kB subunit. (101 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
FOSBProtein fosB. (341 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
NCF2Neutrophil cytosol factor 2. (527 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
SIRPATyrosine-protein phosphatase non-receptor type substrate 1. (503 aa)
LOC102285099Uncharacterized protein. (405 aa)
LOC102285368Uncharacterized protein. (394 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (334 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (244 aa)
SPI1Transcription factor PU.1. (333 aa)
LOC102284581Uncharacterized protein. (186 aa)
NCF4Neutrophil cytosol factor 4. (343 aa)
IRF9Interferon regulatory factor 9. (81 aa)
ITGB3Integrin beta. (788 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (485 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD. (956 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (343 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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