STRINGSTRING
CRB3 CRB3 PRKCI PRKCI CLDN11 CLDN11 SRC SRC ACTN4 ACTN4 MYL9 MYL9 MAP3K1 MAP3K1 PATJ PATJ MYL12A MYL12A LOC102267056 LOC102267056 LOC102267326 LOC102267326 LOC102281726 LOC102281726 GATA4 GATA4 TJP2 TJP2 NEDD4L NEDD4L PPP2CA PPP2CA EZR EZR HSPA4 HSPA4 PARD3 PARD3 CLDN2 CLDN2 JAM3 JAM3 RAB8B RAB8B PARD6A PARD6A LOC102275020 LOC102275020 STK11 STK11 CLDN23 CLDN23 AMOT AMOT ACTR3 ACTR3 LOC102281126 LOC102281126 HCLS1 HCLS1 WAS WAS PCNA PCNA AMOTL2 AMOTL2 CCND1 CCND1 ACTR3C ACTR3C MYH14 MYH14 M91_01832 M91_01832 MARVELD3 MARVELD3 CTTN CTTN CLDN15 CLDN15 AMOTL1 AMOTL1 CLDN18 CLDN18 CLDN7 CLDN7 CLDN8 CLDN8 CLDN17 CLDN17 EPB41L4B EPB41L4B CLDN19 CLDN19 TUBAL3 TUBAL3 SLC9A3R1 SLC9A3R1 PPP2R2B PPP2R2B PRKAG2 PRKAG2 MAGI1 MAGI1 CLDN4 CLDN4 CGNL1 CGNL1 NEDD4 NEDD4 TUBA8 TUBA8 PRKAA2 PRKAA2 PRKAB2 PRKAB2 LLGL2 LLGL2 RAB8A RAB8A RAP1A RAP1A JAM2 JAM2 RAP2C RAP2C LOC102278265 LOC102278265 TIAM1 TIAM1 RUNX1 RUNX1 PARD6B PARD6B MAPK9 MAPK9 M91_08968 M91_08968 MAP3K5 MAP3K5 MYH10 MYH10 TJAP1 TJAP1 CLDN34 CLDN34 ACTN1 ACTN1 TJP1 TJP1 PPP2R1B PPP2R1B ARHGEF2 ARHGEF2 CLDN25 CLDN25 CFTR CFTR CLDN1 CLDN1 CLDN6 CLDN6 CLDN9 CLDN9 RHOA RHOA CDC42 CDC42 SCRIB SCRIB ITGB1 ITGB1 RAPGEF6 RAPGEF6 LOC102267156 LOC102267156 CD1E CD1E LOC102288394 LOC102288394 M91_13196 M91_13196 PPP2R2A PPP2R2A PPP2CB PPP2CB ENSBMUP00000022382 ENSBMUP00000022382 MYL6B MYL6B MPP4 MPP4 ROCK2 ROCK2 PARD6G PARD6G TJP3 TJP3 PRKACA PRKACA LOC102273986 LOC102273986 SYMPK SYMPK SYNPO SYNPO ACTR2 ACTR2 MAPK8 MAPK8 PPP2R2C PPP2R2C F11R F11R VASP VASP ACTB ACTB PRKAB1 PRKAB1 DLG1 DLG1 MAPK10 MAPK10 CLDN14 CLDN14 ROCK1 ROCK1 MSN MSN BVES BVES PRKAG1 PRKAG1 TUBA1A TUBA1A ENSBMUP00000031204 ENSBMUP00000031204 PRKCZ PRKCZ OCLN OCLN MARVELD2 MARVELD2 CLDN20 CLDN20 PRKACB PRKACB MPP5 MPP5 CGN CGN MYH9 MYH9 CACNA1D CACNA1D RAPGEF2 RAPGEF2 NF2 NF2 CDK4 CDK4 MAP2K7 MAP2K7 PRKAG3 PRKAG3 TUBA4A TUBA4A LOC102281213 LOC102281213 PRKAA1 PRKAA1 ACTG1 ACTG1 RDX RDX CLDN10 CLDN10 RAB13 RAB13 YBX3 YBX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRB3Crumbs protein-like protein 3. (128 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (208 aa)
SRCTyrosine-protein kinase. (559 aa)
ACTN4Alpha-actinin-4. (911 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
PATJInaD-like protein. (1907 aa)
MYL12AMyosin regulatory light chain 12A. (178 aa)
LOC102267056Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
LOC102267326Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
LOC102281726Nuclease-sensitive element-binding protein 1-like. (318 aa)
GATA4Transcription factor GATA-4. (236 aa)
TJP2Tight junction protein 2. (1118 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like protein. (1172 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
EZREzrin. (659 aa)
HSPA4Heat shock 70 kDa protein 4. (840 aa)
PARD3Partitioning defective 3-like protein. (1029 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
JAM3Junctional adhesion molecule C. (302 aa)
RAB8BRas-related protein Rab-8B. (207 aa)
PARD6APartitioning defective 6-like protein alpha. (344 aa)
LOC102275020Antigen-presenting glycoprotein CD1d-like. (178 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (287 aa)
AMOTAngiomotin. (1079 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (440 aa)
LOC102281126T-cell surface glycoprotein CD1a. (346 aa)
HCLS1Hematopoietic lineage cell-specific protein. (485 aa)
WASWiskott-Aldrich syndrome protein. (514 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
AMOTL2Angiomotin-like protein 2. (766 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
ACTR3CARP3 actin related protein 3 homolog B. (330 aa)
MYH14Myosin-14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2039 aa)
M91_01832Protein kinase C epsilon type. (145 aa)
MARVELD3MARVEL domain-containing protein 3. (383 aa)
CTTNSrc substrate cortactin. (536 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
AMOTL1Angiomotin-like protein 1. (938 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
EPB41L4BBand 4.1-like protein 4B. (894 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
TUBAL3Tubulin alpha like 3. (446 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1. (204 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (317 aa)
MAGI1Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. (1454 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
CGNL1Cingulin-like protein 1. (1293 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4. (1321 aa)
TUBA8Tubulin alpha 8. (447 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
LLGL2Lethal(2) giant larvae protein-like protein 2. (1020 aa)
RAB8ARAB8A, member RAS oncogene family. (256 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
JAM2Junctional adhesion molecule B. (298 aa)
RAP2CRas-related protein Rap-2c. (183 aa)
LOC102278265Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1. (1591 aa)
RUNX1Runt-related transcription factor 1. (491 aa)
PARD6BPartitioning defective 6-like protein beta. (351 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
M91_08968Nuclease-sensitive element-binding protein 1. (345 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MYH10Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1982 aa)
TJAP1Tight junction-associated protein 1. (558 aa)
CLDN34Uncharacterized protein. (202 aa)
ACTN1Alpha-actinin-1. (964 aa)
TJP1Tight junction protein ZO-1. (1762 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (667 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (1275 aa)
CLDN25Putative claudin-25. (230 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1189 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
RHOATransforming protein RhoA. (193 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
SCRIBScribbled planar cell polarity protein. (1447 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (814 aa)
RAPGEF6Rap guanine nucleotide exchange factor 6. (1608 aa)
LOC102267156T-cell surface glycoprotein CD1b-1. (335 aa)
CD1ET-cell surface glycoprotein CD1e, membrane-associated. (389 aa)
LOC102288394Ig-like domain-containing protein. (352 aa)
M91_13196Uncharacterized protein. (663 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
MYL6BMyosin light chain 6B. (262 aa)
MPP4Membrane palmitoylated protein 4. (640 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1297 aa)
PARD6GPartitioning defective 6-like protein gamma. (371 aa)
TJP3Tight junction protein 3. (933 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
LOC102273986Antigen-presenting glycoprotein CD1d-like. (380 aa)
SYMPKSymplekin. (1272 aa)
SYNPOSynaptopodin. (825 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (339 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (482 aa)
F11RJunctional adhesion molecule A. (303 aa)
VASPVasodilator-stimulated phosphoprotein. (383 aa)
ACTBActin, cytoplasmic 1. (375 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (297 aa)
DLG1Disks large-like protein 1; Belongs to the MAGUK family. (939 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
MSNMoesin. (577 aa)
BVESBlood vessel epicardial substance. (360 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (349 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (451 aa)
ENSBMUP00000031204Tubulin alpha-1C chain. (247 aa)
PRKCZProtein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (592 aa)
OCLNOccludin. (521 aa)
MARVELD2MARVEL domain-containing protein 2. (559 aa)
CLDN20Claudin 20. (219 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
MPP5MAGUK p55 subfamily member 5; Belongs to the MAGUK family. (675 aa)
CGNCingulin. (1194 aa)
MYH9Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1961 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1676 aa)
NF2Neurofibromin 2. (596 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (496 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (448 aa)
LOC102281213Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (452 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
RDXRadixin. (604 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (73 aa)
RAB13Ras-related protein Rab-13. (203 aa)
YBX3DNA-binding protein A. (385 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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