(68 nodes) Antigen processing and presentation network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102272599	C-type lectin domain-containing protein. (198 aa)
	CD8A	T-cell surface glycoprotein CD8 alpha chain. (274 aa)
	CD8B	T-cell surface glycoprotein CD8 beta chain. (208 aa)
	LOC102275967	Uncharacterized protein. (409 aa)
	CTSV	Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
	LOC102279719	NKG2-A/NKG2-B type II integral membrane protein. (243 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8. (646 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (404 aa)
	LOC102278231	BOLA class I histocompatibility antigen, alpha chain BL3-7-like. (240 aa)
	HSPA4	Heat shock 70 kDa protein 4. (840 aa)
	ENSBMUP00000003020	HLA class II histocompatibility antigen, DQ beta 2 chain-like. (149 aa)
	LOC102269978	SLA class II histocompatibility antigen, DQ haplotype D alpha chain; Belongs to the MHC class II family. (255 aa)
	LOC102270256	Ig-like domain-containing protein. (272 aa)
	LOC102271117	HLA class II histocompatibility antigen, DRB1-4 beta chain-like. (242 aa)
	LOC102271676	DLA class II histocompatibility antigen, DR-1 beta chain. (250 aa)
	M91_00611	IGv domain-containing protein. (140 aa)
	LOC102278697	Heat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (599 aa)
	LOC102278977	Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (633 aa)
	M91_10368	Ig-like domain-containing protein; Belongs to the MHC class I family. (377 aa)
	LOC102272326	Ig-like domain-containing protein; Belongs to the MHC class I family. (353 aa)
	LOC102277803	BoLa class II histocompatibility antigen, DQB*0101 beta chain. (254 aa)
	LOC102282432	SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like. (286 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (207 aa)
	LOC102282710	HLA class II histocompatibility antigen, DQ beta 1 chain. (259 aa)
	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain. (255 aa)
	TAP2	Antigen peptide transporter 2. (702 aa)
	TAP1	Antigen peptide transporter 1. (810 aa)
	LOC102269342	HLA class II histocompatibility antigen, DM beta chain. (262 aa)
	HLA-DMA	HLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family. (367 aa)
	HLA-DOA	HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
	TAPBP	TAP binding protein (tapasin). (494 aa)
	M91_15197	Uncharacterized protein. (283 aa)
	LOC102276456	Killer cell lectin-like receptor subfamily D member 1. (175 aa)
	CD4	T-cell surface glycoprotein CD4. (455 aa)
	M91_15255	Ig-like domain-containing protein. (165 aa)
	M91_06422	Ig-like domain-containing protein. (132 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1. (341 aa)
	LOC102284891	Natural killer cells antigen CD94. (186 aa)
	LOC102286014	C-type lectin domain-containing protein. (235 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (722 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (268 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2. (623 aa)
	LOC102286220	BOLA class I histocompatibility antigen, alpha chain BL3-6; Belongs to the MHC class I family. (480 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	HSPA1L	Heat shock 70 kDa protein 1-like protein; Belongs to the heat shock protein 70 family. (641 aa)
	CANX	Calnexin. (593 aa)
	RFXANK	DNA-binding protein RFXANK. (260 aa)
	CALR	Calreticulin. (417 aa)
	LOC102279723	Heat shock protein 90 alpha family class A member 1. (119 aa)
	LGMN	Legumain. (433 aa)
	LOC102276352	NKG2-A/NKG2-B type II integral membrane protein-like. (245 aa)
	M91_20047	Ig-like domain-containing protein. (272 aa)
	CTSL	Cathepsin L1; Belongs to the peptidase C1 family. (330 aa)
	LOC102288356	Ig-like domain-containing protein; Belongs to the MHC class I family. (337 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
	HSPA5	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family. (655 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	HLA-DRA	Mamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (319 aa)
	M91_10783	Ig-like domain-containing protein. (129 aa)
	M91_02837	Uncharacterized protein. (308 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (331 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	RFX5	DNA-binding protein RFX5. (619 aa)
	PSME1	Proteasome activator complex subunit 1. (249 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (348 aa)
	IFI30	Gamma-interferon-inducible lysosomal thiol reductase. (272 aa)
	M91_12975	Ig-like domain-containing protein. (341 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CALR	ENSBMUP00000025063	ENSBMUP00000019823	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calreticulin.	0.760
B2M	CD4	ENSBMUP00000025063	ENSBMUP00000012240	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD4.	0.578
B2M	CD74	ENSBMUP00000025063	ENSBMUP00000017203	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen gamma chain.	0.485
B2M	CD8A	ENSBMUP00000025063	ENSBMUP00000001830	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD8 alpha chain.	0.758
B2M	CD8B	ENSBMUP00000025063	ENSBMUP00000001858	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD8 beta chain.	0.541
B2M	CTSS	ENSBMUP00000025063	ENSBMUP00000031945	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Cathepsin S; Belongs to the peptidase C1 family.	0.682
B2M	HLA-DMA	ENSBMUP00000025063	ENSBMUP00000010418	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family.	0.560
B2M	HLA-DOA	ENSBMUP00000025063	ENSBMUP00000010479	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family.	0.590
B2M	HLA-DRA	ENSBMUP00000025063	ENSBMUP00000029321	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Mamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.603
B2M	IFNG	ENSBMUP00000025063	ENSBMUP00000015309	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.459
B2M	LOC102269342	ENSBMUP00000025063	ENSBMUP00000010374	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DM beta chain.	0.613
B2M	LOC102269978	ENSBMUP00000025063	ENSBMUP00000003132	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	SLA class II histocompatibility antigen, DQ haplotype D alpha chain; Belongs to the MHC class II family.	0.567
B2M	LOC102270256	ENSBMUP00000025063	ENSBMUP00000003246	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.597
B2M	LOC102271676	ENSBMUP00000025063	ENSBMUP00000004089	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DLA class II histocompatibility antigen, DR-1 beta chain.	0.597
B2M	LOC102272326	ENSBMUP00000025063	ENSBMUP00000009567	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.937
B2M	LOC102276456	ENSBMUP00000025063	ENSBMUP00000012031	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin-like receptor subfamily D member 1.	0.443
B2M	LOC102277803	ENSBMUP00000025063	ENSBMUP00000009833	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	BoLa class II histocompatibility antigen, DQB*0101 beta chain.	0.597
B2M	LOC102278231	ENSBMUP00000025063	ENSBMUP00000002961	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	BOLA class I histocompatibility antigen, alpha chain BL3-7-like.	0.975
B2M	LOC102282710	ENSBMUP00000025063	ENSBMUP00000010219	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	HLA class II histocompatibility antigen, DQ beta 1 chain.	0.597
B2M	LOC102284891	ENSBMUP00000025063	ENSBMUP00000013653	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Natural killer cells antigen CD94.	0.453