STRINGSTRING
RRAS2 RRAS2 FCER1G FCER1G PRKCD PRKCD SRC SRC CCL22 CCL22 CCL17 CCL17 IKBKB IKBKB RELA RELA MAP3K14 MAP3K14 NFKB2 NFKB2 MALT1 MALT1 NFATC3 NFATC3 NFKBIA NFKBIA IL12B IL12B RRAS RRAS CARD9 CARD9 CALM3 CALM3 M91_10145 M91_10145 HRAS HRAS CALML4 CALML4 NRAS NRAS MRAS MRAS PIK3CB PIK3CB CALML5 CALML5 IL1B IL1B NFATC4 NFATC4 PTPN11 PTPN11 ARHGEF12 ARHGEF12 PIK3R1 PIK3R1 SYK SYK RAF1 RAF1 MDM2 MDM2 CBLB CBLB KSR1 KSR1 MAPK9 MAPK9 CALM1 CALM1 MAPK13 MAPK13 MAPK14 MAPK14 TNF TNF PPP3CC PPP3CC EGR3 EGR3 RHOA RHOA IRF1 IRF1 CLEC4D CLEC4D CLEC4E CLEC4E PPP3CA PPP3CA IL2 IL2 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 ITPR1 ITPR1 STAT1 STAT1 LOC102287375 LOC102287375 PIK3CA PIK3CA PLK3 PLK3 CASP8 CASP8 CHUK CHUK IL23A IL23A STAT2 STAT2 BCL10 BCL10 LOC102285474 LOC102285474 NLRP3 NLRP3 PIK3R3 PIK3R3 NFKB1 NFKB1 LSP1 LSP1 RELB-2 RELB-2 KRAS KRAS MAPK8 MAPK8 PPP3R1 PPP3R1 PLCG2 PLCG2 CLEC1B CLEC1B CLEC7A CLEC7A IL6 IL6 MAPK10 MAPK10 PTGS2 PTGS2 ITPR2 ITPR2 LOC102280361 LOC102280361 PAK1 PAK1 IL12A IL12A IRF9 IRF9 IL10 IL10 MAPKAPK2 MAPKAPK2 PYCARD PYCARD IKBKE IKBKE PIK3R2 PIK3R2 CYLD CYLD CD209 CD209 MAPK3 MAPK3 AKT1 AKT1 PPP3CB PPP3CB IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRAS2Ras-related protein R-Ras2. (173 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (111 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
SRCTyrosine-protein kinase. (559 aa)
CCL22C-C motif chemokine. (93 aa)
CCL17C-C motif chemokine. (102 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
RELATranscription factor p65. (549 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
MALT1Uncharacterized protein. (828 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1038 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
RRASRas-related protein R-Ras. (218 aa)
CARD9Caspase recruitment domain-containing protein 9. (539 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
M91_10145Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
CALML4Calmodulin-like protein 4. (197 aa)
NRASGTPase NRas. (189 aa)
MRASRas-related protein M-Ras. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALML5Calmodulin. (148 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1549 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SYKNon-specific protein-tyrosine kinase. (629 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (982 aa)
KSR1Kinase suppressor of Ras 1. (928 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
EGR3Early growth response protein 3. (349 aa)
RHOATransforming protein RhoA. (193 aa)
IRF1Interferon regulatory factor. (322 aa)
CLEC4DC-type lectin domain family 4 member D. (213 aa)
CLEC4EC-type lectin domain family 4 member E. (211 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
STAT1Signal transducer and activator of transcription. (817 aa)
LOC102287375Calmodulin. (149 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (485 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
IL23AInterleukin-23 subunit alpha. (192 aa)
STAT2Signal transducer and activator of transcription. (857 aa)
BCL10B-cell lymphoma/leukemia 10. (230 aa)
LOC102285474Nuclear factor of activated T-cells, cytoplasmic 1-like. (454 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3. (1032 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
LSP1Lymphocyte-specific protein 1. (232 aa)
RELB-2RELB proto-oncogene, NF-kB subunit. (101 aa)
KRASGTPase KRas. (189 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
CLEC1BC-type lectin domain family 1 member B. (226 aa)
CLEC7AC-type lectin domain family 7 member A. (247 aa)
IL6Interleukin-6. (254 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
LOC102280361Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
IL12AInterleukin 12A. (221 aa)
IRF9Interferon regulatory factor 9. (81 aa)
IL10Interleukin-10. (179 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon. (718 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD. (956 aa)
CD209CD209 antigen. (259 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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