STRINGSTRING
TAB1 TAB1 ATF4 ATF4 IKBKB IKBKB IL15 IL15 TRAF2 TRAF2 RELA RELA CASP3 CASP3 MAP3K14 MAP3K14 CXCL6 CXCL6 LOC102269246 LOC102269246 EDN1 EDN1 IL18R1 IL18R1 CSF1 CSF1 NFKBIA NFKBIA TRAF3 TRAF3 TRADD TRADD MMP9 MMP9 ITCH ITCH DNM1L DNM1L MAP2K1 MAP2K1 BIRC2 BIRC2 TRAF5 TRAF5 TNFRSF1A TNFRSF1A LOC102280497 LOC102280497 LOC102282466 LOC102282466 LOC102281065 LOC102281065 PIK3CB PIK3CB FOS FOS IL1B IL1B RIPK3 RIPK3 SOCS3 SOCS3 TNFAIP3 TNFAIP3 PIK3R1 PIK3R1 RIPK1 RIPK1 MAP3K8 MAP3K8 CREB1 CREB1 BAG4 BAG4 RPS6KA5 RPS6KA5 MAPK9 MAPK9 MAP3K5 MAP3K5 MAP2K4 MAP2K4 CCL5 CCL5 MAPK13 MAPK13 TNFRSF1B TNFRSF1B MAPK14 MAPK14 TAB2 TAB2 M91_15258 M91_15258 CCL2 CCL2 TNF TNF CCL20 CCL20 RPS6KA4 RPS6KA4 IRF1 IRF1 CSF2 CSF2 CREB3L2 CREB3L2 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 TRAF1 TRAF1 CASP7 CASP7 TAB3 TAB3 MAP2K3 MAP2K3 PIK3CA PIK3CA FAS FAS MAP3K7 MAP3K7 CASP8 CASP8 CHUK CHUK LOC102286351 LOC102286351 CREB3L3 CREB3L3 PIK3R3 PIK3R3 BIRC3 BIRC3 ENSBMUP00000025018 ENSBMUP00000025018 MMP14 MMP14 CREB5 CREB5 NFKB1 NFKB1 MAPK8 MAPK8 VEGFD VEGFD LOC102278214 LOC102278214 SELE SELE IL6 IL6 MAPK10 MAPK10 PGAM5 PGAM5 PTGS2 PTGS2 MLKL MLKL VEGFC VEGFC CREB3L1 CREB3L1 LOC102271748 LOC102271748 MAP2K6 MAP2K6 ATF6B ATF6B CREB3 CREB3 LOC102284581 LOC102284581 JAG1 JAG1 ATF2 ATF2 MMP3 MMP3 LIF LIF PIK3R2 PIK3R2 NOD2 NOD2 MAP2K7 MAP2K7 MAPK3 MAPK3 AKT1 AKT1 CFLAR CFLAR CREB3L4 CREB3L4 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TRAF2TNF receptor associated factor 2. (311 aa)
RELATranscription factor p65. (549 aa)
CASP3Caspase 3. (276 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
CXCL6C-X-C motif chemokine. (112 aa)
LOC102269246C-X-C motif chemokine. (103 aa)
EDN1Endothelin-1. (202 aa)
IL18R1Interleukin-18 receptor 1. (556 aa)
CSF1Macrophage colony-stimulating factor 1. (545 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (354 aa)
MMP9Matrix metalloproteinase-9. (712 aa)
ITCHE3 ubiquitin-protein ligase Itchy. (862 aa)
DNM1LDynamin 1-like protein. (749 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (623 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
LOC102280497Interferon beta-3. (182 aa)
LOC102282466Interferon beta-2. (187 aa)
LOC102281065Uncharacterized protein. (186 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3. (504 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (780 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (666 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
BAG4BAG family molecular chaperone regulator 4. (416 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (723 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
CCL5C-C motif chemokine. (91 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (438 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2. (409 aa)
M91_15258Intercellular adhesion molecule 1. (321 aa)
CCL2C-C motif chemokine. (99 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CCL20C-C motif chemokine. (96 aa)
RPS6KA4Ribosomal protein S6 kinase alpha-4. (773 aa)
IRF1Interferon regulatory factor. (322 aa)
CSF2Uncharacterized protein. (143 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FASTumor necrosis factor receptor superfamily member 6. (323 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (485 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
LOC102286351Interferon-inducible GTPase 1. (458 aa)
CREB3L3CAMP responsive element binding protein 3 like 3. (456 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
ENSBMUP00000025018Intercellular adhesion molecule 1-like. (132 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
LOC102278214Intercellular adhesion molecule 1-like. (545 aa)
SELEE-selectin. (485 aa)
IL6Interleukin-6. (254 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial. (140 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
MLKLMixed lineage kinase domain-like protein. (468 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
LOC102271748Vascular cell adhesion protein 1. (740 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (707 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
LOC102284581Uncharacterized protein. (186 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
MMP3Stromelysin-1. (500 aa)
LIFLeukemia inhibitory factor. (202 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (511 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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