STRINGSTRING
GSK3B GSK3B NGFR NGFR PRKCD PRKCD ATF4 ATF4 ARHGDIB ARHGDIB GAB1 GAB1 IKBKB IKBKB RELA RELA MAP3K1 MAP3K1 SH2B1 SH2B1 NTRK3 NTRK3 BCL2 BCL2 NGF NGF NFKBIA NFKBIA SORT1 SORT1 KIDINS220 KIDINS220 PRDM4 PRDM4 FASLG FASLG CALM3 CALM3 M91_10145 M91_10145 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 MAP2K5 MAP2K5 CALML4 CALML4 NRAS NRAS PIK3CB PIK3CB MAP3K3 MAP3K3 CALML5 CALML5 GRB2 GRB2 PTPN11 PTPN11 PSEN2 PSEN2 TRAF6 TRAF6 RAP1A RAP1A PSEN1 PSEN1 PIK3R1 PIK3R1 YWHAE YWHAE RIPK2 RIPK2 IRAK2 IRAK2 RAF1 RAF1 SHC1 SHC1 RAP1B RAP1B IRAK3 IRAK3 NFKBIE NFKBIE RPS6KA5 RPS6KA5 MAPK9 MAPK9 MAP3K5 MAP3K5 CAMK2A CAMK2A CALM1 CALM1 MAPK13 MAPK13 MAPK14 MAPK14 IRS1 IRS1 LOC102269967 LOC102269967 IRAK4 IRAK4 RHOA RHOA BAD BAD NFKBIB NFKBIB IRAK1 IRAK1 PDPK1 PDPK1 MAPK7 MAPK7 CDC42 CDC42 NTF4 NTF4 MAPK12 MAPK12 MAPK11 MAPK11 NTRK1 NTRK1 AKT2 AKT2 LOC102287375 LOC102287375 RPS6KA1 RPS6KA1 PIK3CA PIK3CA SHC3 SHC3 RPS6KA3 RPS6KA3 MATK MATK FRS2 FRS2 MAP2K2 MAP2K2 PIK3R3 PIK3R3 NTRK2 NTRK2 FOXO3 FOXO3 CRKL CRKL NFKB1 NFKB1 KRAS KRAS MAPK8 MAPK8 PLCG2 PLCG2 SH2B3 SH2B3 SOS2 SOS2 TP53 TP53 MAPK10 MAPK10 ZNF274 ZNF274 SHC4 SHC4 TP73 TP73 LOC102280361 LOC102280361 BDNF BDNF ARHGDIG ARHGDIG CAMK4 CAMK4 MAPKAPK2 MAPKAPK2 PIK3R2 PIK3R2 NTF3 NTF3 MAP2K7 MAP2K7 MAPK3 MAPK3 AKT1 AKT1 ARHGDIA ARHGDIA PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (428 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
ARHGDIBRho GDP-dissociation inhibitor 2. (200 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
RELATranscription factor p65. (549 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
SH2B1SH2B adapter protein 1. (683 aa)
NTRK3NT-3 growth factor receptor. (476 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (299 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
SORT1Sortilin. (831 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa. (1710 aa)
PRDM4PR domain zinc finger protein 4. (800 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (277 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
M91_10145Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CALML4Calmodulin-like protein 4. (197 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
CALML5Calmodulin. (148 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (449 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (539 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (621 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
SHC1SHC-transforming protein 1. (501 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (580 aa)
NFKBIENF-kappa-B inhibitor epsilon. (362 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (723 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
LOC102269967Ras-related protein Rap-1b-like. (184 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (461 aa)
RHOATransforming protein RhoA. (193 aa)
BADBcl2 antagonist of cell death. (168 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (640 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (782 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
NTF4Neurotrophin 4. (210 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC102287375Calmodulin. (149 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
SHC3SHC-transforming protein 3. (105 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (712 aa)
MATKTyrosine-protein kinase. (485 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
FOXO3Forkhead box protein O3. (453 aa)
CRKLCrk-like protein. (302 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
KRASGTPase KRas. (189 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
SH2B3SH2B adapter protein 3. (568 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
ZNF274Neurotrophin receptor-interacting factor homolog. (620 aa)
SHC4SHC-transforming protein 4. (630 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
LOC102280361Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (258 aa)
ARHGDIGRho GDP-dissociation inhibitor 3. (256 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (485 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (279 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
ARHGDIARho GDP-dissociation inhibitor 1. (264 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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