STRINGSTRING
KCNQ4 KCNQ4 GNGT2 GNGT2 ATF4 ATF4 GNAI1 GNAI1 PLCB2 PLCB2 GNB2 GNB2 LOC102269855 LOC102269855 ADCY9 ADCY9 BCL2 BCL2 GNAI3 GNAI3 GNGT1 GNGT1 GNG11 GNG11 CHRNA3 CHRNA3 CHRNB4 CHRNB4 CACNA1F CACNA1F CACNA1S CACNA1S GNG2 GNG2 JAK2 JAK2 GNG8 GNG8 CHRNA7 CHRNA7 ADCY8 ADCY8 MAP2K1 MAP2K1 CHRNA4 CHRNA4 HRAS HRAS ADCY1 ADCY1 NRAS NRAS ADCY3 ADCY3 PIK3CB PIK3CB KCNJ6 KCNJ6 FOS FOS SLC5A7 SLC5A7 PIK3CG PIK3CG ADCY4 ADCY4 CACNA1C-2 CACNA1C-2 CHRM3 CHRM3 GNG4 GNG4 GNB3 GNB3 PIK3R1 PIK3R1 CREB1 CREB1 GNB5 GNB5 GNG12 GNG12 CHRNB2 CHRNB2 PIK3R5 PIK3R5 PIK3R6 PIK3R6 CAMK2A CAMK2A LOC102271265 LOC102271265 GNA11 GNA11 GNG7 GNG7 CHRM2 CHRM2 PLCB3 PLCB3 CREB3L2 CREB3L2 AKT2 AKT2 ITPR1 ITPR1 KCNJ12 KCNJ12 CHRM5 CHRM5 PIK3CA PIK3CA KCNJ14 KCNJ14 GNAQ GNAQ GNB4 GNB4 FYN FYN KCNQ2 KCNQ2 CACNA1A CACNA1A CREB3L3 CREB3L3 PIK3R3 PIK3R3 ACHE ACHE PRKACA PRKACA CREB5 CREB5 CHAT CHAT KRAS KRAS CHRNA6 CHRNA6 GNAI2 GNAI2 PLCB1 PLCB1 ITPR2 ITPR2 KCNQ3 KCNQ3 CREB3L1 CREB3L1 ADCY6 ADCY6 CHRM4 CHRM4 KCNJ2 KCNJ2 GNG3 GNG3 GNG13 GNG13 GNB1 GNB1 CHRM1 CHRM1 GNG5 GNG5 CREB3 CREB3 PRKACB PRKACB KCNQ1 KCNQ1 KCNJ3 KCNJ3 PRKCG PRKCG CACNA1D CACNA1D CAMK4 CAMK4 PRKCA PRKCA PIK3R2 PIK3R2 ADCY7 ADCY7 MAPK3 MAPK3 AKT1 AKT1 KCNJ4 KCNJ4 CREB3L4 CREB3L4
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNQ4Potassium voltage-gated channel subfamily KQT member 4; Belongs to the potassium channel family. (695 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (80 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha. (354 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (296 aa)
LOC102269855Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11. (73 aa)
CHRNA3Neuronal acetylcholine receptor subunit alpha-3. (510 aa)
CHRNB4Neuronal acetylcholine receptor subunit beta-4. (462 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1965 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7. (531 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
CHRNA4Neuronal acetylcholine receptor subunit alpha-4. (614 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
ADCY1Adenylate cyclase 1. (310 aa)
NRASGTPase NRas. (189 aa)
ADCY3Adenylate cyclase type 3. (1145 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
FOSProto-oncogene c-Fos. (380 aa)
SLC5A7High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1104 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CACNA1C-2Voltage-dependent calcium channel L type alpha-1C. (1249 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (356 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (353 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2. (503 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5/6. (886 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
LOC102271265Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (465 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12. (427 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
KCNJ14Potassium inwardly-rectifying channel subfamily J member 14. (430 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
FYNTyrosine-protein kinase. (537 aa)
KCNQ2Potassium voltage-gated channel subfamily KQT member 2; Belongs to the potassium channel family. (873 aa)
CACNA1AVoltage-dependent calcium channel P/Q type alpha-1A. (2312 aa)
CREB3L3CAMP responsive element binding protein 3 like 3. (456 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ACHEAcetylcholinesterase (Cartwright blood group). (615 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (667 aa)
KRASGTPase KRas. (189 aa)
CHRNA6Neuronal acetylcholine receptor subunit alpha-6. (494 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
KCNQ3Potassium voltage-gated channel subfamily KQT member 3; Belongs to the potassium channel family. (866 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ADCY6Adenylate cyclase 6. (1163 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (480 aa)
KCNJ2Inward rectifier potassium channel 2. (427 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (452 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (676 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (235 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (485 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
KCNJ4Inward rectifier potassium channel 4. (444 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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