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PRKCD PRKCD CYP2J2 CYP2J2 SRC SRC PLCB2 PLCB2 PRKCQ PRKCQ BDKRB1 BDKRB1 BDKRB2 BDKRB2 ADCY9 ADCY9 NGF NGF ASIC3 ASIC3 PTGER2 PTGER2 ALOX12 ALOX12 CALM3 CALM3 ADCY8 ADCY8 M91_10145 M91_10145 M91_01832 M91_01832 ADCY1 ADCY1 CALML4 CALML4 ADCY3 ADCY3 PIK3CB PIK3CB CALML5 CALML5 IL1R1 IL1R1 HRH1 HRH1 IL1B IL1B ADCY4 ADCY4 ENSBMUP00000011087 ENSBMUP00000011087 PIK3R1 PIK3R1 IGF1 IGF1 PLA2G6 PLA2G6 F2RL1 F2RL1 MAPK9 MAPK9 TRPV1 TRPV1 TRPV3 TRPV3 CAMK2A CAMK2A CALM1 CALM1 PPP1CB PPP1CB HTR2A HTR2A MAPK13 MAPK13 MAPK14 MAPK14 LOC102266645 LOC102266645 TRPV2 TRPV2 PLCB3 PLCB3 MAPK12 MAPK12 MAPK11 MAPK11 NTRK1 NTRK1 ITPR1 ITPR1 MAP2K3 MAP2K3 LOC102266046 LOC102266046 LOC102287375 LOC102287375 PIK3CA PIK3CA GNAQ GNAQ KNG1 KNG1 LOC102268262 LOC102268262 PIK3R3 PIK3R3 PRKACA PRKACA TRPA1 TRPA1 P2RY2 P2RY2 LOC102286095 LOC102286095 PLA2G4B PLA2G4B LOC102266153 LOC102266153 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F LOC102279786 LOC102279786 MAPK8 MAPK8 PLCG2 PLCG2 PPP1CC PPP1CC PPP1CA PPP1CA MAPK10 MAPK10 TRPV4 TRPV4 HTR2C HTR2C PLCB1 PLCB1 PLA2G4A PLA2G4A ITPR2 ITPR2 ADCY6 ADCY6 MAP2K6 MAP2K6 LOC102280361 LOC102280361 PRKACB PRKACB PRKCG PRKCG PRKCH PRKCH TRPM8 TRPM8 PRKCA PRKCA PIK3R2 PIK3R2 ADCY7 ADCY7 HTR2B HTR2B PLCG1 PLCG1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
CYP2J2Cytochrome P450 2J2; Belongs to the cytochrome P450 family. (502 aa)
SRCTyrosine-protein kinase. (559 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
BDKRB1B1 bradykinin receptor. (374 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (388 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (299 aa)
ASIC3Amiloride-sensitive cation channel 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (521 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (352 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (653 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
M91_10145Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
M91_01832Protein kinase C epsilon type. (145 aa)
ADCY1Adenylate cyclase 1. (310 aa)
CALML4Calmodulin-like protein 4. (197 aa)
ADCY3Adenylate cyclase type 3. (1145 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALML5Calmodulin. (148 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
HRH1Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (491 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSBMUP000000110875-hydroxytryptamine receptor 2C. (108 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
PLA2G685 kDa calcium-independent phospholipase A2. (805 aa)
F2RL1Proteinase-activated receptor 2. (388 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1. (832 aa)
TRPV3Transient receptor putative cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (791 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
HTR2A5-hydroxytryptamine receptor 2A. (493 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
LOC102266645Amiloride-sensitive cation channel 2, neuronal; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (559 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2. (754 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC102266046Uncharacterized protein. (448 aa)
LOC102287375Calmodulin. (149 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
KNG1Kininogen-1. (642 aa)
LOC102268262Cytochrome P450 family 2 subfamily C. (480 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
TRPA1Transient receptor putative cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1121 aa)
P2RY2p2Y purinoceptor 2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
LOC102286095Cytochrome P450 4A11; Belongs to the cytochrome P450 family. (517 aa)
PLA2G4BPhospholipase A2. (784 aa)
LOC102266153Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (394 aa)
PLA2G4EPhospholipase A2. (860 aa)
PLA2G4DPhospholipase A2. (808 aa)
PLA2G4FPhospholipase A2. (844 aa)
LOC102279786Cytochrome P450 2C19; Belongs to the cytochrome P450 family. (493 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
TRPV4Transient receptor putative cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
HTR2C5-hydroxytryptamine receptor 2C. (280 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
PLA2G4APhospholipase A2. (749 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY6Adenylate cyclase 6. (1163 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC102280361Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
PRKCHProtein kinase C eta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (683 aa)
TRPM8Transient receptor putative cation channel subfamily M member 8. (1104 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
HTR2B5-hydroxytryptamine receptor 2B. (538 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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