(80 nodes) Melanogenesis network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSK3B	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
	GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha. (354 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
	DCT	Dopachrome tautomerase. (514 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
	EDN1	Endothelin-1. (202 aa)
	CREBBP	CREB-binding protein. (2203 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	GNAI3	Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
	CALM3	Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
	ADCY8	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
	M91_10145	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1. (393 aa)
	HRAS	HRas proto-oncogene, GTPase. (182 aa)
	ADCY1	Adenylate cyclase 1. (310 aa)
	CALML4	Calmodulin-like protein 4. (197 aa)
	NRAS	GTPase NRas. (189 aa)
	ADCY3	Adenylate cyclase type 3. (1145 aa)
	POMC	Pro-opiomelanocortin. (264 aa)
	CALML5	Calmodulin. (148 aa)
	FZD9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	EDNRB	Endothelin receptor type B. (441 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1. (341 aa)
	FZD5	Frizzled class receptor 5. (545 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
	MITF	Microphthalmia-associated transcription factor. (520 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	FZD1	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (650 aa)
	WNT3A	Wingless-type MMTV integration site family, member 3. (348 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase. (537 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	CREB3L2	Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
	EP300	E1A binding protein p300. (2371 aa)
	TCF7L2	Transcription factor 7-like 2. (536 aa)
	LOC102287375	Calmodulin. (149 aa)
	GNAQ	Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	FZD7	Frizzled class receptor 7. (558 aa)
	KITLG-2	Kit ligand. (196 aa)
	LEF1	Lymphoid enhancer-binding factor 1. (414 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	CREB3L3	CAMP responsive element binding protein 3 like 3. (456 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
	TYR	Tyrosinase. (530 aa)
	FZD4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
	LOC102266153	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (394 aa)
	KRAS	GTPase KRas. (189 aa)
	FZD2	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (515 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
	ASIP	Agouti-signaling protein. (132 aa)
	PLCB1	Phosphoinositide phospholipase C. (1183 aa)
	ENSBMUP00000030233	Wingless-type MMTV integration site family, member 7. (190 aa)
	ENSBMUP00000030236	Wingless-type MMTV integration site family, member 7. (154 aa)
	CREB3L1	Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
	ADCY6	Adenylate cyclase 6. (1163 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	LOC102280361	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	FZD10	Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	CREB3	Cyclic AMP-responsive element-binding protein 3. (365 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	DVL1	Segment polarity protein dishevelled-like protein DVL-1. (691 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
	TCF7L1	Transcription factor 7-like 1. (575 aa)
	PRKCA	Protein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
	WNT10A	Wingless-type MMTV integration site family, member 10. (393 aa)
	FZD6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
	CREB3L4	Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY3	ENSBMUP00000008220	ENSBMUP00000008344	Adenylate cyclase 1.	Adenylate cyclase type 3.	0.940
ADCY1	ADCY4	ENSBMUP00000008220	ENSBMUP00000010523	Adenylate cyclase 1.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ADCY1	ADCY6	ENSBMUP00000008220	ENSBMUP00000030688	Adenylate cyclase 1.	Adenylate cyclase 6.	0.413
ADCY1	ADCY7	ENSBMUP00000008220	ENSBMUP00000034700	Adenylate cyclase 1.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.537
ADCY1	ADCY8	ENSBMUP00000008220	ENSBMUP00000007004	Adenylate cyclase 1.	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.940
ADCY1	ADCY9	ENSBMUP00000008220	ENSBMUP00000003931	Adenylate cyclase 1.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.527
ADCY1	CALM1	ENSBMUP00000008220	ENSBMUP00000016212	Adenylate cyclase 1.	Uncharacterized protein; Belongs to the calmodulin family.	0.921
ADCY1	CALM3	ENSBMUP00000008220	ENSBMUP00000006743	Adenylate cyclase 1.	Uncharacterized protein; Belongs to the calmodulin family.	0.921
ADCY1	CALML4	ENSBMUP00000008220	ENSBMUP00000008301	Adenylate cyclase 1.	Calmodulin-like protein 4.	0.921
ADCY1	CALML5	ENSBMUP00000008220	ENSBMUP00000009142	Adenylate cyclase 1.	Calmodulin.	0.930
ADCY1	CAMK2A	ENSBMUP00000008220	ENSBMUP00000016142	Adenylate cyclase 1.	Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily.	0.910
ADCY1	GNAI1	ENSBMUP00000008220	ENSBMUP00000000876	Adenylate cyclase 1.	Guanine nucleotide-binding protein G(i) subunit alpha.	0.809
ADCY1	GNAI2	ENSBMUP00000008220	ENSBMUP00000028737	Adenylate cyclase 1.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.789
ADCY1	GNAI3	ENSBMUP00000008220	ENSBMUP00000004489	Adenylate cyclase 1.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.789
ADCY1	LOC102266153	ENSBMUP00000008220	ENSBMUP00000026048	Adenylate cyclase 1.	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas.	0.958
ADCY1	LOC102280361	ENSBMUP00000008220	ENSBMUP00000031126	Adenylate cyclase 1.	Uncharacterized protein; Belongs to the calmodulin family.	0.921
ADCY1	LOC102287375	ENSBMUP00000008220	ENSBMUP00000022003	Adenylate cyclase 1.	Calmodulin.	0.930
ADCY1	M91_10145	ENSBMUP00000008220	ENSBMUP00000007290	Adenylate cyclase 1.	Uncharacterized protein; Belongs to the calmodulin family.	0.921
ADCY1	PRKACA	ENSBMUP00000008220	ENSBMUP00000024830	Adenylate cyclase 1.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.922
ADCY1	PRKACB	ENSBMUP00000008220	ENSBMUP00000032367	Adenylate cyclase 1.	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	0.924