STRINGSTRING
SRC SRC GNAI1 GNAI1 PLCB2 PLCB2 MYL9 MYL9 CACNB1 CACNB1 NFATC3 NFATC3 ADCY9 ADCY9 GNAI3 GNAI3 CACNA1F CACNA1F CACNA1S CACNA1S KCNJ5 KCNJ5 CALM3 CALM3 ADCY8 ADCY8 PPP1R12A PPP1R12A M91_10145 M91_10145 CCND1 CCND1 MAP2K1 MAP2K1 HRAS HRAS MAP2K5 MAP2K5 ADCY1 ADCY1 CALML4 CALML4 NRAS NRAS ADCY3 ADCY3 KCNJ6 KCNJ6 CALML5 CALML5 FOS FOS PIK3CG PIK3CG NFATC4 NFATC4 ADCY4 ADCY4 PRKAG2 PRKAG2 CACNA2D4 CACNA2D4 CACNA1C-2 CACNA1C-2 CACNB2 CACNB2 PRKAA2 PRKAA2 PRKAB2 PRKAB2 RAF1 RAF1 MYLK MYLK MYLK3 MYLK3 CAMK1 CAMK1 MYLK4 MYLK4 PIK3R5 PIK3R5 PIK3R6 PIK3R6 OXTR OXTR CAMK2A CAMK2A CALM1 CALM1 CDKN1A CDKN1A PPP1CB PPP1CB NPPA NPPA RYR1 RYR1 KCNJ9 KCNJ9 CAMK1D CAMK1D CACNA2D3 CACNA2D3 TRPM2 TRPM2 PPP3CC PPP3CC RHOA RHOA PLCB3 PLCB3 MAPK7 MAPK7 PPP3CA PPP3CA LOC102269868 LOC102269868 GUCY1A1 GUCY1A1 GUCY1B1 GUCY1B1 ITPR1 ITPR1 KCNJ12 KCNJ12 RYR3 RYR3 LOC102287375 LOC102287375 KCNJ14 KCNJ14 GNAQ GNAQ MYL6B MYL6B ROCK2 ROCK2 PPP1R12B PPP1R12B CACNA2D1 CACNA2D1 LOC102285474 LOC102285474 EEF2 EEF2 CAMKK2 CAMKK2 MAP2K2 MAP2K2 PRKACA PRKACA PLA2G4B PLA2G4B LOC102266153 LOC102266153 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F KRAS KRAS CACNG3 CACNG3 PPP3R1 PPP3R1 CACNA2D2 CACNA2D2 RGS2 RGS2 CACNB4 CACNB4 PPP1CC PPP1CC ACTB ACTB PPP1CA PPP1CA GNAI2 GNAI2 PRKAB1 PRKAB1 ROCK1 ROCK1 PLCB1 PLCB1 LOC102285947 LOC102285947 PTGS2 PTGS2 PLA2G4A PLA2G4A RYR2 RYR2 ITPR2 ITPR2 ADCY6 ADCY6 CACNB3 CACNB3 PRKAG1 PRKAG1 KCNJ2 KCNJ2 LOC102280361 LOC102280361 PRKACB PRKACB NPR2 NPR2 KCNJ3 KCNJ3 CACNG6 CACNG6 CACNG7 CACNG7 CACNG2 CACNG2 PRKCG PRKCG CACNA1D CACNA1D CAMK4 CAMK4 PRKCA PRKCA CACNG5 CACNG5 ADCY7 ADCY7 ELK1 ELK1 PRKAG3 PRKAG3 PRKAA1 PRKAA1 MAPK3 MAPK3 KCNJ4 KCNJ4 ACTG1 ACTG1 NPR1 NPR1 PPP3CB PPP3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (559 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha. (354 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1. (643 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1038 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1965 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1067 aa)
M91_10145Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
ADCY1Adenylate cyclase 1. (310 aa)
CALML4Calmodulin-like protein 4. (197 aa)
NRASGTPase NRas. (189 aa)
ADCY3Adenylate cyclase type 3. (1145 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
CALML5Calmodulin. (148 aa)
FOSProto-oncogene c-Fos. (380 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1104 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (317 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (552 aa)
CACNA1C-2Voltage-dependent calcium channel L type alpha-1C. (1249 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2. (658 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
MYLKMyosin light chain kinase, smooth muscle. (340 aa)
MYLK3Putative myosin light chain kinase 3. (786 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (394 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (357 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5/6. (886 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
NPPAAtrial natriuretic factor. (188 aa)
RYR1Uncharacterized protein. (3719 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (405 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D. (385 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3. (1080 aa)
TRPM2Transient receptor putative cation channel subfamily M member 2. (1493 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
RHOATransforming protein RhoA. (193 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (782 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (598 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12. (427 aa)
RYR3Ryanodine receptor 3. (4877 aa)
LOC102287375Calmodulin. (149 aa)
KCNJ14Potassium inwardly-rectifying channel subfamily J member 14. (430 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MYL6BMyosin light chain 6B. (262 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1297 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit 12B. (502 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1. (1103 aa)
LOC102285474Nuclear factor of activated T-cells, cytoplasmic 1-like. (454 aa)
EEF2Elongation factor 2. (858 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (579 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
PLA2G4BPhospholipase A2. (784 aa)
LOC102266153Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (394 aa)
PLA2G4EPhospholipase A2. (860 aa)
PLA2G4DPhospholipase A2. (808 aa)
PLA2G4FPhospholipase A2. (844 aa)
KRASGTPase KRas. (189 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2. (1153 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4. (520 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ACTBActin, cytoplasmic 1. (375 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (297 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
LOC102285947Guanylate cyclase soluble subunit beta-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (774 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
PLA2G4APhospholipase A2. (749 aa)
RYR2Ryanodine receptor 2. (4951 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY6Adenylate cyclase 6. (1163 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3. (484 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (349 aa)
KCNJ2Inward rectifier potassium channel 2. (427 aa)
LOC102280361Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
NPR2Atrial natriuretic peptide receptor B. (1047 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (235 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit. (260 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG2Calcium voltage-gated channel auxiliary subunit gamma 2. (294 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (485 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (496 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
KCNJ4Inward rectifier potassium channel 4. (444 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
NPR1Guanylate cyclase. (1058 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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