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HCN1 HCN1 PLCB2 PLCB2 TRPC5 TRPC5 GABBR2 GABBR2 HCN2 HCN2 ARRB1 ARRB1 CACNA1F CACNA1F ARRB2 ARRB2 CACNA1S CACNA1S KCNJ5 KCNJ5 MAP2K1 MAP2K1 HRAS HRAS NRAS NRAS PIK3CB PIK3CB KCNJ6 KCNJ6 CACNA1C-2 CACNA1C-2 PIK3R1 PIK3R1 KCNN3 KCNN3 RAF1 RAF1 CGA CGA GNA11 GNA11 HCN3 HCN3 KCNJ9 KCNJ9 KISS1R KISS1R ESR2 ESR2 PLCB3 PLCB3 TRPC4 TRPC4 LHB LHB AKT2 AKT2 ITPR1 ITPR1 KCNN2 KCNN2 GNRH1 GNRH1 PIK3CA PIK3CA GNAQ GNAQ KISS1 KISS1 KCNN4 KCNN4 MAP2K2 MAP2K2 PIK3R3 PIK3R3 KCNJ11 KCNJ11 KRAS KRAS TRPC1 TRPC1 SPP1 SPP1 CACNA1G CACNA1G PLCB1 PLCB1 ITPR2 ITPR2 KCNJ3 KCNJ3 PRKCG PRKCG CACNA1D CACNA1D KCNN1 KCNN1 PRKCA PRKCA PIK3R2 PIK3R2 MAPK3 MAPK3 AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (296 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5. (971 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (310 aa)
HCN2Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2. (852 aa)
ARRB1Beta-arrestin-1. (429 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1965 aa)
ARRB2Arrestin beta 2. (401 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
CACNA1C-2Voltage-dependent calcium channel L type alpha-1C. (1249 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
KCNN3Small conductance calcium-activated potassium channel protein 3. (733 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
HCN3Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3. (783 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (405 aa)
KISS1RKiSS-1 receptor. (227 aa)
ESR2Estrogen receptor beta. (527 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
TRPC4Short transient receptor putative channel 4; Belongs to the transient receptor (TC 1.A.4) family. (981 aa)
LHBLuteinizing hormone beta polypeptide. (141 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
KCNN2Small conductance calcium-activated potassium channel protein 2. (529 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
KISS1Metastasis-suppressor KiSS-1. (134 aa)
KCNN4Intermediate conductance calcium-activated potassium channel protein 4. (428 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (388 aa)
KRASGTPase KRas. (189 aa)
TRPC1Short transient receptor putative channel 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
SPP1Osteopontin. (338 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (235 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
KCNN1Small conductance calcium-activated potassium channel protein 1. (543 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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