STRINGSTRING
GSK3B GSK3B PRKCD PRKCD IKBKB IKBKB PRKCQ PRKCQ MTOR MTOR PTPA PTPA RELA RELA OGA OGA NFKBIA NFKBIA G6PC2 G6PC2 RPS6KB1 RPS6KB1 PYGL PYGL CPT1A CPT1A PPP1R3A PPP1R3A M91_01832 M91_01832 NR1H2 NR1H2 SLC2A2 SLC2A2 PTEN PTEN TNFRSF1A TNFRSF1A PIK3CB PIK3CB SLC2A4 SLC2A4 PYGB PYGB SLC2A1 SLC2A1 AGT AGT PRKAG2 PRKAG2 PTPN11 PTPN11 PPARGC1A PPARGC1A PRKAA2 PRKAA2 PRKAB2 PRKAB2 SOCS3 SOCS3 PIK3R1 PIK3R1 CREB1 CREB1 SLC27A6 SLC27A6 PTPN1 PTPN1 GFPT2 GFPT2 MAPK9 MAPK9 PPP1CB PPP1CB PPP1R3B PPP1R3B IRS1 IRS1 TNF TNF PYGM PYGM PDPK1 PDPK1 CREB3L2 CREB3L2 PPARGC1B PPARGC1B GYS1 GYS1 AKT2 AKT2 STAT3 STAT3 PTPRF PTPRF RPS6KA1 RPS6KA1 PIK3CA PIK3CA CPT1B CPT1B PCK1 PCK1 RPS6KA3 RPS6KA3 LOC102266138 LOC102266138 FOXO1 FOXO1 CREB3L3 CREB3L3 PIK3R3 PIK3R3 G6PC3 G6PC3 PPP1R3D PPP1R3D G6PC G6PC CREB5 CREB5 NFKB1 NFKB1 MAPK8 MAPK8 SLC27A4 SLC27A4 GFPT1 GFPT1 TBC1D4 TBC1D4 PPP1CC PPP1CC PPP1CA PPP1CA RPS6KB2 RPS6KB2 PRKAB1 PRKAB1 IL6 IL6 MAPK10 MAPK10 ACACB ACACB PPARA PPARA SLC27A2 SLC27A2 CREB3L1 CREB3L1 PRKAG1 PRKAG1 PRKCZ PRKCZ NR1H3 NR1H3 PPP1R3C PPP1R3C CREB3 CREB3 OGT OGT PCK2 PCK2 SLC27A1 SLC27A1 PIK3R2 PIK3R2 PRKAG3 PRKAG3 INSR INSR PRKAA1 PRKAA1 AKT1 AKT1 CRTC2 CRTC2 CREB3L4 CREB3L4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (324 aa)
RELATranscription factor p65. (549 aa)
OGABifunctional protein NCOAT. (916 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
G6PC2Glucose-6-phosphatase 2. (355 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
PYGLGlycogen phosphorylase L. (851 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1149 aa)
M91_01832Protein kinase C epsilon type. (145 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (454 aa)
SLC2A2MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 2. (522 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
AGTAngiotensinogen; Belongs to the serpin family. (456 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (317 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (796 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
SLC27A6Solute carrier family 27 (fatty acid transporter), member 6. (619 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type 1. (429 aa)
GFPT2Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2. (675 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit 3B. (339 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (990 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (736 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F. (1878 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform; Belongs to the carnitine/choline acetyltransferase family. (771 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (712 aa)
LOC102266138Uncharacterized protein; Belongs to the CD36 family. (472 aa)
FOXO1Forkhead box protein O1. (468 aa)
CREB3L3CAMP responsive element binding protein 3 like 3. (456 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
G6PC3Glucose-6-phosphatase 3. (453 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (299 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (356 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
GFPT1Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1. (603 aa)
TBC1D4TBC1 domain family member 4. (1295 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (297 aa)
IL6Interleukin-6. (254 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
ACACBAcetyl-CoA carboxylase / biotin carboxylase 2. (2240 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (470 aa)
SLC27A2Very long-chain acyl-CoA synthetase. (620 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (349 aa)
PRKCZProtein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (592 aa)
NR1H3Oxysterols receptor LXR-alpha. (446 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C. (318 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. (1046 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
SLC27A1Long-chain fatty acid transport protein 1. (646 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (496 aa)
INSRInsulin receptor. (1382 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
CRTC2CREB-regulated transcription coactivator 2. (693 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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