STRINGSTRING
GSK3B GSK3B ATF4 ATF4 GHRH GHRH GNAI1 GNAI1 PLCB2 PLCB2 MTOR MTOR MAP3K1 MAP3K1 SSTR2 SSTR2 CREBBP CREBBP ADCY9 ADCY9 GNAI3 GNAI3 ADCY10 ADCY10 CACNA1F CACNA1F POU1F1 POU1F1 CACNA1S CACNA1S JAK2 JAK2 ADCY8 ADCY8 MAP2K1 MAP2K1 GHSR GHSR SOCS2 SOCS2 HRAS HRAS SOS1 SOS1 IGFBP3 IGFBP3 LOC102271788 LOC102271788 ADCY1 ADCY1 GHRL GHRL NRAS NRAS ADCY3 ADCY3 PIK3CB PIK3CB FOS FOS ADCY4 ADCY4 CACNA1C-2 CACNA1C-2 GRB2 GRB2 SOCS3 SOCS3 PIK3R1 PIK3R1 IGF1 IGF1 CREB1 CREB1 GHRHR GHRHR RAF1 RAF1 SHC1 SHC1 MAPK9 MAPK9 SST SST MAP2K4 MAP2K4 PTK2 PTK2 GNA11 GNA11 MAPK13 MAPK13 MAPK14 MAPK14 IRS1 IRS1 PLCB3 PLCB3 CREB3L2 CREB3L2 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 ITPR1 ITPR1 STAT1 STAT1 SSTR1 SSTR1 EP300 EP300 MAP2K3 MAP2K3 STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B PIK3CA PIK3CA GNAQ GNAQ SHC3 SHC3 IGFALS IGFALS MAP2K2 MAP2K2 CREB3L3 CREB3L3 PIK3R3 PIK3R3 PRKACA PRKACA CRKL CRKL LOC102266153 LOC102266153 CREB5 CREB5 KRAS KRAS IRS4 IRS4 MAPK8 MAPK8 PLCG2 PLCG2 SOS2 SOS2 GNAI2 GNAI2 MAPK10 MAPK10 BCAR1 BCAR1 PLCB1 PLCB1 SHC4 SHC4 ITPR2 ITPR2 CREB3L1 CREB3L1 ADCY6 ADCY6 MAP2K6 MAP2K6 ATF6B ATF6B SSTR5 SSTR5 CREB3 CREB3 PRKACB PRKACB SSTR3 SSTR3 PRKCG PRKCG CACNA1D CACNA1D ATF2 ATF2 PRKCA PRKCA PIK3R2 PIK3R2 ADCY7 ADCY7 GHR GHR MAPK3 MAPK3 AKT1 AKT1 PLCG1 PLCG1 CREB3L4 CREB3L4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
GHRHSomatoliberin. (106 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha. (354 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CREBBPCREB-binding protein. (2203 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ADCY10Adenylate cyclase type 10. (1614 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1965 aa)
POU1F1POU domain protein. (317 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
IGFBP3Insulin like growth factor binding protein 3. (289 aa)
LOC102271788Somatotropin. (216 aa)
ADCY1Adenylate cyclase 1. (310 aa)
GHRLAppetite-regulating hormone. (116 aa)
NRASGTPase NRas. (189 aa)
ADCY3Adenylate cyclase type 3. (1145 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
CACNA1C-2Voltage-dependent calcium channel L type alpha-1C. (1249 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
SHC1SHC-transforming protein 1. (501 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SSTSomatostatin. (116 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
PTK2Focal adhesion kinase 1. (1065 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
STAT1Signal transducer and activator of transcription. (817 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (525 aa)
EP300E1A binding protein p300. (2371 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription 5B. (787 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
SHC3SHC-transforming protein 3. (105 aa)
IGFALSInsulin-like growth factor-binding protein complex acid labile subunit. (552 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3CAMP responsive element binding protein 3 like 3. (456 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
CRKLCrk-like protein. (302 aa)
LOC102266153Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (394 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
KRASGTPase KRas. (189 aa)
IRS4Insulin receptor substrate 4. (1207 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (866 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
SHC4SHC-transforming protein 4. (630 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ADCY6Adenylate cyclase 6. (1163 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (707 aa)
SSTR5Somatostatin receptor type 5; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SSTR3Somatostatin receptor type 3; Belongs to the G-protein coupled receptor 1 family. (422 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
GHRGrowth hormone receptor. (634 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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