STRINGSTRING
RHOG RHOG LOC102276866 LOC102276866 PODXL PODXL TAB1 TAB1 KLC2 KLC2 IKBKB IKBKB TRAF2 TRAF2 RELA RELA MYL9 MYL9 CASP3 CASP3 PLEKHM1 PLEKHM1 MYL12A MYL12A LOC102280438 LOC102280438 PAK3 PAK3 SNX9 SNX9 CXCL8 CXCL8 SNX33 SNX33 KPNA3 KPNA3 DYNC1I2 DYNC1I2 DYNLL2 DYNLL2 FYCO1 FYCO1 FBXO22 FBXO22 BCL2 BCL2 NFKBIA NFKBIA AHNAK2 AHNAK2 M91_14072 M91_14072 ABI1 ABI1 DNM2 DNM2 RRAS RRAS FHOD1 FHOD1 RALA RALA TRADD TRADD FLNB FLNB VPS41 VPS41 PIK3C2G PIK3C2G DYNC1LI2 DYNC1LI2 DYNLRB1 DYNLRB1 PFN1 PFN1 M6PR M6PR CSE1L CSE1L ELMO2 ELMO2 RHOB RHOB MAP2K1 MAP2K1 BIRC2 BIRC2 TNFSF10 TNFSF10 PFN4 PFN4 HRAS HRAS MYL10 MYL10 DYNLRB2 DYNLRB2 TNFRSF1A TNFRSF1A TXN TXN PIK3CB PIK3CB TLR5 TLR5 CYFIP1 CYFIP1 NOD1 NOD1 FOS FOS DYNC1I1 DYNC1I1 GCC2 GCC2 ELMO1 ELMO1 IL1B IL1B TLR9 TLR9 MYC MYC PIK3CG PIK3CG RAB9B RAB9B RIPK3 RIPK3 GAPDH GAPDH DYNC1LI1 DYNC1LI1 TLR2 TLR2 RAB5A RAB5A CYTH1 CYTH1 BAK1 BAK1 TRAF6 TRAF6 TLR4 TLR4 RIPK1 RIPK1 LY96 LY96 CASP1 CASP1 LOC102279942 LOC102279942 EXOC7 EXOC7 RIPK2 RIPK2 BRK1 BRK1 VPS11 VPS11 RAF1 RAF1 HSP90B1 HSP90B1 ARPC4 ARPC4 HSP90AB1 HSP90AB1 EXOC2 EXOC2 MAPK9 MAPK9 ANXA2 ANXA2 M91_08976 M91_08976 DYNC2H1 DYNC2H1 LOC102277620 LOC102277620 MAP2K4 MAP2K4 IL18 IL18 KLC4 KLC4 MAPK13 MAPK13 LOC102279019 LOC102279019 EXOC4 EXOC4 MAPK14 MAPK14 ARF1 ARF1 TAB2 TAB2 TNF TNF FLNA FLNA RHOJ RHOJ CYTH3 CYTH3 RAB7A RAB7A KPNA1 KPNA1 IRAK4 IRAK4 RHOA RHOA IRAK1 IRAK1 DYNC1H1 DYNC1H1 LOC102279723 LOC102279723 MYO6 MYO6 ARPC1A ARPC1A CDC42 CDC42 STX10 STX10 WASL WASL CYFIP2 CYFIP2 CD14 CD14 ACBD3 ACBD3 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 SKP1-2 SKP1-2 RHOH RHOH EXOC5 EXOC5 CASP7 CASP7 TAB3 TAB3 MAP2K3 MAP2K3 TCF7L2 TCF7L2 PIK3CA PIK3CA RAB5C RAB5C M91_03436 M91_03436 MAP3K7 MAP3K7 CASP8 CASP8 CTNNB1 CTNNB1 LOC102285827 LOC102285827 NCKAP1 NCKAP1 RAB5B RAB5B VPS33A VPS33A RAB7B RAB7B CHUK CHUK PKN1 PKN1 M91_05762 M91_05762 ROCK2 ROCK2 PIK3C2B PIK3C2B MYD88 MYD88 VPS18 VPS18 LEF1 LEF1 NLRC4 NLRC4 NLRP3 NLRP3 MAP2K2 MAP2K2 PIK3C2A PIK3C2A BIRC3 BIRC3 TLR6 TLR6 NFKB1 NFKB1 VPS39 VPS39 RPS3-2 RPS3-2 VPS16 VPS16 MAPK8 MAPK8 ARPC5L ARPC5L NCKAP1L NCKAP1L ARPC3 ARPC3 ACTB ACTB ARPC5 ARPC5 ARF6 ARF6 KLC1 KLC1 IL6 IL6 MAPK10 MAPK10 MYLPF MYLPF MLKL MLKL PIK3C3 PIK3C3 AHNAK AHNAK FLNC FLNC MAP2K6 MAP2K6 PAK1 PAK1 NAIP NAIP KPNA4 KPNA4 RAB9A RAB9A LOC106700494 LOC106700494 CYTH4 CYTH4 S100A10 S100A10 TXN2 TXN2 PYCARD PYCARD PLEKHM2 PLEKHM2 TCF7L1 TCF7L1 ARPC2 ARPC2 MAP2K7 MAP2K7 MYL7 MYL7 MAPK3 MAPK3 AKT1 AKT1 ACTG1 ACTG1 LOC102277261 LOC102277261 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOGRho-related GTP-binding protein RhoG. (191 aa)
LOC102276866Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
PODXLPodocalyxin. (509 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
KLC2Kinesin light chain 2. (622 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
TRAF2TNF receptor associated factor 2. (311 aa)
RELATranscription factor p65. (549 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
CASP3Caspase 3. (276 aa)
PLEKHM1Pleckstrin-like protein domain-containing family M member 1. (1055 aa)
MYL12AMyosin regulatory light chain 12A. (178 aa)
LOC102280438ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PAK3Serine/threonine-protein kinase PAK 3. (580 aa)
SNX9Sorting nexin-9. (600 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SNX33Sorting nexin. (571 aa)
KPNA3Importin subunit alpha-3. (506 aa)
DYNC1I2Cytoplasmic dynein 1 intermediate chain 2. (638 aa)
DYNLL2Dynein light chain. (128 aa)
FYCO1FYVE and coiled-coil domain-containing protein 1. (1470 aa)
FBXO22F-box only protein 22. (404 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
AHNAK2Protein AHNAK2. (757 aa)
M91_14072DH domain-containing protein. (424 aa)
ABI1Abl interactor 1. (508 aa)
DNM2Dynamin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
RRASRas-related protein R-Ras. (218 aa)
FHOD1Formin homology 2 domain containing 1. (1007 aa)
RALARas-related protein Ral-A. (206 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (354 aa)
FLNBFilamin-B. (2633 aa)
VPS41Vacuolar protein sorting-associated protein 41-like protein. (854 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma. (230 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (492 aa)
DYNLRB1Robl_LC7 domain-containing protein. (96 aa)
PFN1Profilin; Belongs to the profilin family. (137 aa)
M6PRCation-dependent mannose-6-phosphate receptor. (279 aa)
CSE1LExportin-2. (973 aa)
ELMO2Engulfment and cell motility protein 2. (720 aa)
RHOBRho-related GTP-binding protein RhoB. (196 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (623 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (287 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
MYL10Myosin regulatory light chain 10. (168 aa)
DYNLRB2Robl_LC7 domain-containing protein. (96 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
TXNThioredoxin. (105 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
CYFIP1Cytoplasmic FMR1-interacting protein 1. (1253 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (954 aa)
FOSProto-oncogene c-Fos. (380 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (585 aa)
GCC2GRIP and coiled-coil domain-containing protein 2. (1700 aa)
ELMO1Engulfment and cell motility protein 1. (727 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
TLR9Toll like receptor 9. (1006 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1104 aa)
RAB9BRas-related protein Rab-9B. (201 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3. (504 aa)
GAPDHGlyceraldehyde 3-phosphate dehydrogenase. (379 aa)
DYNC1LI1Dynein cytoplasmic 1 light intermediate chain 1. (475 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (800 aa)
RAB5ARas-related protein Rab-5A. (215 aa)
CYTH1Cytohesin-1. (455 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (801 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (666 aa)
LY96Lymphocyte antigen 96. (160 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (403 aa)
LOC102279942Dynein light chain. (89 aa)
EXOC7Exocyst complex component 7. (707 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (539 aa)
BRK1Uncharacterized protein. (75 aa)
VPS11Vacuolar protein sorting-associated protein 11. (941 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
HSP90B1Endoplasmin. (809 aa)
ARPC4Actin-related protein 2/3 complex subunit 4. (188 aa)
HSP90AB1Heat shock protein HSP 90-beta. (722 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ANXA2Annexin. (339 aa)
M91_08976Profilin; Belongs to the profilin family. (135 aa)
DYNC2H1Cytoplasmic dynein 2 heavy chain 1. (4314 aa)
LOC102277620Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
KLC4Kinesin light chain 4. (616 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC102279019Sec8_exocyst domain-containing protein. (465 aa)
EXOC4Exocyst complex component 4. (553 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2. (409 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FLNAFilamin-A. (2647 aa)
RHOJRho-related GTP-binding protein RhoJ. (274 aa)
CYTH3Cytohesin-3. (399 aa)
RAB7ARas-related protein Rab-7a. (247 aa)
KPNA1Importin subunit alpha-1. (538 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (461 aa)
RHOATransforming protein RhoA. (193 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (640 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4641 aa)
LOC102279723Heat shock protein 90 alpha family class A member 1. (119 aa)
MYO6Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (790 aa)
ARPC1AActin-related protein 2/3 complex subunit 1A-like. (279 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
STX10Syntaxin-10. (249 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (511 aa)
CYFIP2Cytoplasmic FMR1 interacting protein 2. (1275 aa)
CD14Monocyte differentiation antigen CD14. (383 aa)
ACBD3Golgi resident protein GCP60. (521 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SKP1-2S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
EXOC5Exocyst complex component 5. (714 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
RAB5CRas-related protein Rab-5C. (216 aa)
M91_03436Endo/exonuclease/phosphatase domain-containing protein. (345 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (485 aa)
CTNNB1Catenin beta-1. (781 aa)
LOC102285827Dynein light chain 1, cytoplasmic-like. (87 aa)
NCKAP1Nck-associated protein 1. (1028 aa)
RAB5BRas-related protein Rab-5B. (215 aa)
VPS33AVacuolar protein sorting-associated protein 33A; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
RAB7BRas-related protein Rab-7b. (197 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
PKN1Serine/threonine-protein kinase N1. (956 aa)
M91_05762Dynein light chain. (109 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1297 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
MYD88Myeloid differentiation primary response protein MyD88. (296 aa)
VPS18Vacuolar protein sorting-associated protein 18-like protein. (973 aa)
LEF1Lymphoid enhancer-binding factor 1. (414 aa)
NLRC4NLR family CARD domain-containing protein 4. (1017 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3. (1032 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha. (1688 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
TLR6Toll like receptor 6. (793 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
VPS39Vam6/Vps39-like protein. (875 aa)
RPS3-240S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (115 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (164 aa)
NCKAP1LNck-associated protein 1-like protein. (1128 aa)
ARPC3Actin-related protein 2/3 complex subunit 3. (178 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ARPC5Actin related protein 2/3 complex, subunit 5. (151 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
KLC1Kinesin light chain 1. (701 aa)
IL6Interleukin-6. (254 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
MLKLMixed lineage kinase domain-like protein. (468 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
AHNAKNeuroblast differentiation-associated protein AHNAK. (148 aa)
FLNCFilamin-C. (2720 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
NAIPBaculoviral IAP repeat-containing protein 1. (1350 aa)
KPNA4Importin subunit alpha-4. (497 aa)
RAB9ARas-related protein Rab-9A. (202 aa)
LOC106700494Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
CYTH4Cytohesin-4. (394 aa)
S100A10Protein S100-A10; Belongs to the S-100 family. (97 aa)
TXN2Thioredoxin, mitochondrial. (166 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
PLEKHM2Pleckstrin-like protein domain-containing family M member 2. (1025 aa)
TCF7L1Transcription factor 7-like 1. (575 aa)
ARPC2Actin related protein 2/3 complex, subunit 2. (413 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
LOC102277261Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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