STRINGSTRING
GNAI1 GNAI1 IKBKB IKBKB PLCB2 PLCB2 RELA RELA CXCL8 CXCL8 PPP2CA PPP2CA BDKRB2 BDKRB2 NFKBIA NFKBIA IL12B IL12B M91_00611 M91_00611 GNAI3 GNAI3 FASLG FASLG SERPINE1 SERPINE1 ADCY1 ADCY1 TGFBR1 TGFBR1 TNFRSF1A TNFRSF1A LOC102280497 LOC102280497 LOC102282466 LOC102282466 LOC102281065 LOC102281065 PIK3CB PIK3CB SMAD2 SMAD2 FOS FOS IL1B IL1B TLR9 TLR9 PPP2R2B PPP2R2B IFNGR2 IFNGR2 TGFB2 TGFB2 TLR2 TLR2 TRAF6 TRAF6 M91_15255 M91_15255 TLR4 TLR4 M91_06422 M91_06422 PIK3R1 PIK3R1 TICAM1 TICAM1 LOC102278265 LOC102278265 IFNG IFNG NOS2 NOS2 MAPK9 MAPK9 IFNGR1 IFNGR1 CD3G CD3G CD3D CD3D CD3E CD3E LOC102287625 LOC102287625 LOC102272762 LOC102272762 MAP2K4 MAP2K4 CCL5 CCL5 GNA15 GNA15 GNA11 GNA11 MAPK13 MAPK13 MAPK14 MAPK14 CCL2 CCL2 PPP2R1B PPP2R1B TNF TNF IRAK4 IRAK4 PLCB3 PLCB3 IRAK1 IRAK1 CALR CALR C1QB C1QB C1QC C1QC C1QA C1QA IL2 IL2 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 TGFBR2 TGFBR2 M91_13196 M91_13196 GNAL GNAL PPP2R2A PPP2R2A PIK3CA PIK3CA FAS FAS GNA14 GNA14 GNAQ GNAQ PPP2CB PPP2CB ENSBMUP00000022382 ENSBMUP00000022382 CASP8 CASP8 CHUK CHUK KNG1 KNG1 MYD88 MYD88 PIK3R3 PIK3R3 TLR6 TLR6 LOC102266153 LOC102266153 NFKB1 NFKB1 MAPK8 MAPK8 PPP2R2C PPP2R2C GNAI2 GNAI2 IL6 IL6 MAPK10 MAPK10 PLCB1 PLCB1 TGFB1 TGFB1 M91_10783 M91_10783 IL12A IL12A LOC102284581 LOC102284581 LOC102273543 LOC102273543 ACE ACE IL10 IL10 C3 C3 PIK3R2 PIK3R2 MAPK3 MAPK3 AKT1 AKT1 CFLAR CFLAR IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha. (354 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
RELATranscription factor p65. (549 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (388 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
M91_00611IGv domain-containing protein. (140 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (277 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
ADCY1Adenylate cyclase 1. (310 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
LOC102280497Interferon beta-3. (182 aa)
LOC102282466Interferon beta-2. (187 aa)
LOC102281065Uncharacterized protein. (186 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SMAD2Mothers against decapentaplegic homolog. (468 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
TLR9Toll like receptor 9. (1006 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
IFNGR2Interferon gamma receptor 2. (363 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (800 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
M91_15255Ig-like domain-containing protein. (165 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (801 aa)
M91_06422Ig-like domain-containing protein. (132 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
TICAM1Toll like receptor adaptor molecule 1. (688 aa)
LOC102278265Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (175 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (172 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (197 aa)
LOC102287625C-C motif chemokine. (125 aa)
LOC102272762C-C motif chemokine. (93 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
CCL5C-C motif chemokine. (91 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (369 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
CCL2C-C motif chemokine. (99 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (667 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (461 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (640 aa)
CALRCalreticulin. (417 aa)
C1QBComplement C1q subcomponent subunit B. (247 aa)
C1QCComplement C1q subcomponent subunit C. (243 aa)
C1QAComplement C1q subcomponent subunit A. (244 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
M91_13196Uncharacterized protein. (663 aa)
GNALGuanine nucleotide-binding protein G(olf) subunit alpha. (135 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FASTumor necrosis factor receptor superfamily member 6. (323 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (485 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
KNG1Kininogen-1. (642 aa)
MYD88Myeloid differentiation primary response protein MyD88. (296 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
TLR6Toll like receptor 6. (793 aa)
LOC102266153Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (394 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (482 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
IL6Interleukin-6. (254 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
PLCB1Phosphoinositide phospholipase C. (1183 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
M91_10783Ig-like domain-containing protein. (129 aa)
IL12AInterleukin 12A. (221 aa)
LOC102284581Uncharacterized protein. (186 aa)
LOC102273543Angiotensin-converting enzyme. (720 aa)
ACEAngiotensin-converting enzyme. (1306 aa)
IL10Interleukin-10. (179 aa)
C3Complement component 3. (1740 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (511 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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