STRINGSTRING
CCNA2 CCNA2 RAN RAN LOC102280145 LOC102280145 VDAC3 VDAC3 ATF4 ATF4 BUB1B BUB1B IKBKB IKBKB FOSL1 FOSL1 IL15 IL15 KAT5 KAT5 RELA RELA IL2RA IL2RA MAP3K1 MAP3K1 IL15RA IL15RA RB1 RB1 MAP3K14 MAP3K14 NFKB2 NFKB2 VDAC1 VDAC1 CCNE2 CCNE2 LOC102278231 LOC102278231 ENSBMUP00000003020 ENSBMUP00000003020 JAK1 JAK1 LOC102269978 LOC102269978 ITGB2 ITGB2 LOC102270256 LOC102270256 LOC102271117 LOC102271117 NFATC3 NFATC3 MSX1 MSX1 CREBBP CREBBP ADCY9 ADCY9 PTTG1 PTTG1 LOC102271676 LOC102271676 NFKBIA NFKBIA M91_00611 M91_00611 TSPO TSPO BUB3 BUB3 RANBP1 RANBP1 ETS2 ETS2 ADCY8 ADCY8 CD40 CD40 CCND1 CCND1 MAP2K1 MAP2K1 MMP7 MMP7 CCNB2 CCNB2 SMAD3 SMAD3 HRAS HRAS ADCY1 ADCY1 TGFBR1 TGFBR1 PTEN PTEN TNFRSF1A TNFRSF1A NRAS NRAS LTBR LTBR ADCY3 ADCY3 CCNE1 CCNE1 GPS2 GPS2 PIK3CB PIK3CB MAP3K3 MAP3K3 SLC2A1 SLC2A1 SMAD2 SMAD2 M91_10368 M91_10368 LOC102272326 LOC102272326 IL1R2 IL1R2 FOS FOS LOC102277803 LOC102277803 IL1R1 IL1R1 LOC102282432 LOC102282432 NFYB NFYB LOC102282710 LOC102282710 HLA-DOB HLA-DOB LOC102269342 LOC102269342 MYC MYC HLA-DMA HLA-DMA NFATC4 NFATC4 HLA-DOA HLA-DOA ADCY4 ADCY4 TBPL1 TBPL1 TGFB2 TGFB2 KAT2B KAT2B ANAPC4 ANAPC4 LOC102271928 LOC102271928 M91_13835 M91_13835 CD4 CD4 M91_15255 M91_15255 M91_06422 M91_06422 TBPL2 TBPL2 PIK3R1 PIK3R1 CREB1 CREB1 SLC25A5 SLC25A5 SLC25A4 SLC25A4 CDKN2A CDKN2A ENSBMUP00000015430 ENSBMUP00000015430 MAPK9 MAPK9 CD3G CD3G CD3D CD3D CD3E CD3E LOC102271380 LOC102271380 MAP2K4 MAP2K4 SRF SRF CDKN1A CDKN1A E2F3 E2F3 ANAPC10 ANAPC10 FDPS FDPS M91_15258 M91_15258 LOC102286220 LOC102286220 TNF TNF CCNA1 CCNA1 PPP3CC PPP3CC CCND3 CCND3 CSF2 CSF2 CANX CANX CREB3L2 CREB3L2 CALR CALR TRRAP TRRAP BCL2L1 BCL2L1 ZFP36 ZFP36 PPP3CA PPP3CA IL2 IL2 NRP1 NRP1 CDKN2C CDKN2C VDAC2 VDAC2 AKT2 AKT2 TGFBR2 TGFBR2 EP300 EP300 STAT5A STAT5A STAT5B STAT5B PIK3CA PIK3CA KAT2A KAT2A M91_20047 M91_20047 CDC20 CDC20 CHUK CHUK MSX2 MSX2 ANAPC5 ANAPC5 LOC102288356 LOC102288356 TLN2 TLN2 LOC102285474 LOC102285474 MAP2K2 MAP2K2 CREB3L3 CREB3L3 PIK3R3 PIK3R3 PRKACA PRKACA ENSBMUP00000025018 ENSBMUP00000025018 B2M B2M MAD1L1 MAD1L1 CREB5 CREB5 NFKB1 NFKB1 RELB-2 RELB-2 KRAS KRAS MAPK8 MAPK8 PPP3R1 PPP3R1 ATR ATR LOC102278214 LOC102278214 ANAPC7 ANAPC7 TP53 TP53 IL6 IL6 DLG1 DLG1 MAPK10 MAPK10 HLA-DRA HLA-DRA ITGAL ITGAL SLC25A6 SLC25A6 ESPL1 ESPL1 SLC25A31 SLC25A31 VAC14 VAC14 CREB3L1 CREB3L1 ADCY6 ADCY6 LOC102266500 LOC102266500 XIAP XIAP TGFB1 TGFB1 ATF6B ATF6B M91_10783 M91_10783 CDC26 CDC26 CDC16 CDC16 SMAD4 SMAD4 TLN1 TLN1 CREB3 CREB3 PRKACB PRKACB ELK4 ELK4 SPI1 SPI1 ANAPC1 ANAPC1 IL2RB IL2RB E2F1 E2F1 CDC27 CDC27 ATF2 ATF2 IL2RG IL2RG CDK4 CDK4 JAK3 JAK3 PIK3R2 PIK3R2 ADCY7 ADCY7 CDC23 CDC23 ELK1 ELK1 EGR1 EGR1 CCND2 CCND2 ANAPC2 ANAPC2 TBP TBP XPO1 XPO1 MAPK3 MAPK3 AKT1 AKT1 ANAPC11 ANAPC11 M91_12975 M91_12975 CRTC2 CRTC2 CREB3L4 CREB3L4 PPP3CB PPP3CB IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNA2Cyclin-A2; Belongs to the cyclin family. (417 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
LOC102280145GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (284 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1051 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (267 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
RELATranscription factor p65. (549 aa)
IL2RAInterleukin-2 receptor subunit alpha. (286 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
IL15RAInterleukin-15 receptor subunit alpha. (311 aa)
RB1Retinoblastoma-associated protein. (880 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
LOC102278231BOLA class I histocompatibility antigen, alpha chain BL3-7-like. (240 aa)
ENSBMUP00000003020HLA class II histocompatibility antigen, DQ beta 2 chain-like. (149 aa)
JAK1Janus kinase 1. (1158 aa)
LOC102269978SLA class II histocompatibility antigen, DQ haplotype D alpha chain; Belongs to the MHC class II family. (255 aa)
ITGB2Integrin subunit beta 2. (860 aa)
LOC102270256Ig-like domain-containing protein. (272 aa)
LOC102271117HLA class II histocompatibility antigen, DRB1-4 beta chain-like. (242 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1038 aa)
MSX1Homeobox protein MSX-1. (303 aa)
CREBBPCREB-binding protein. (2203 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
PTTG1Securin. (202 aa)
LOC102271676DLA class II histocompatibility antigen, DR-1 beta chain. (250 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
M91_00611IGv domain-containing protein. (140 aa)
TSPOUncharacterized protein. (202 aa)
BUB3Mitotic checkpoint protein BUB3. (337 aa)
RANBP1Ran-specific GTPase-activating protein. (225 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
MMP7Matrilysin. (276 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
ADCY1Adenylate cyclase 1. (310 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
NRASGTPase NRas. (189 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (380 aa)
ADCY3Adenylate cyclase type 3. (1145 aa)
CCNE1G1/S-specific cyclin-E1. (411 aa)
GPS2G protein pathway suppressor 2. (327 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
SMAD2Mothers against decapentaplegic homolog. (468 aa)
M91_10368Ig-like domain-containing protein; Belongs to the MHC class I family. (377 aa)
LOC102272326Ig-like domain-containing protein; Belongs to the MHC class I family. (353 aa)
IL1R2Interleukin-1 receptor type 2. (400 aa)
FOSProto-oncogene c-Fos. (380 aa)
LOC102277803BoLa class II histocompatibility antigen, DQB*0101 beta chain. (254 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
LOC102282432SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like. (286 aa)
NFYBNuclear transcription factor Y subunit beta. (207 aa)
LOC102282710HLA class II histocompatibility antigen, DQ beta 1 chain. (259 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain. (255 aa)
LOC102269342HLA class II histocompatibility antigen, DM beta chain. (262 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
HLA-DMAHLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family. (367 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
HLA-DOAHLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KAT2BHistone acetyltransferase KAT2B. (832 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
LOC102271928Uncharacterized protein. (215 aa)
M91_13835Serine-protein kinase ATM. (319 aa)
CD4T-cell surface glycoprotein CD4. (455 aa)
M91_15255Ig-like domain-containing protein. (165 aa)
M91_06422Ig-like domain-containing protein. (132 aa)
TBPL2TATA box-binding protein-like protein 2. (435 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoform 4. (153 aa)
ENSBMUP00000015430Mitotic spindle assembly checkpoint protein MAD2A. (103 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (175 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (172 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (197 aa)
LOC102271380Uncharacterized protein. (174 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
SRFSerum response factor. (467 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
E2F3Transcription factor E2F3. (334 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
FDPSFarnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (353 aa)
M91_15258Intercellular adhesion molecule 1. (321 aa)
LOC102286220BOLA class I histocompatibility antigen, alpha chain BL3-6; Belongs to the MHC class I family. (480 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (292 aa)
CSF2Uncharacterized protein. (143 aa)
CANXCalnexin. (593 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CALRCalreticulin. (417 aa)
TRRAPTransformation/transcription domain associated protein. (3848 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
ZFP36Tristetraprolin. (341 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
NRP1Neuropilin-1. (923 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (294 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EP300E1A binding protein p300. (2371 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription 5B. (787 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
KAT2AHistone acetyltransferase KAT2A. (837 aa)
M91_20047Ig-like domain-containing protein. (272 aa)
CDC20Cell division cycle protein 20-like protein. (499 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
MSX2Homeobox protein MSX-2. (267 aa)
ANAPC5Anaphase-promoting complex subunit 5. (742 aa)
LOC102288356Ig-like domain-containing protein; Belongs to the MHC class I family. (337 aa)
TLN2Talin 2. (2542 aa)
LOC102285474Nuclear factor of activated T-cells, cytoplasmic 1-like. (454 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3CAMP responsive element binding protein 3 like 3. (456 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
ENSBMUP00000025018Intercellular adhesion molecule 1-like. (132 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1. (714 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
RELB-2RELB proto-oncogene, NF-kB subunit. (101 aa)
KRASGTPase KRas. (189 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
LOC102278214Intercellular adhesion molecule 1-like. (545 aa)
ANAPC7Anaphase-promoting complex subunit 7. (599 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
IL6Interleukin-6. (254 aa)
DLG1Disks large-like protein 1; Belongs to the MAGUK family. (939 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
HLA-DRAMamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (319 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1165 aa)
SLC25A6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (278 aa)
ESPL1Separin. (2100 aa)
SLC25A31Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
VAC14Protein VAC14-like protein. (526 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ADCY6Adenylate cyclase 6. (1163 aa)
LOC102266500Serine/threonine-protein kinase Chk1. (256 aa)
XIAPBaculoviral IAP repeat-containing protein 4. (497 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (707 aa)
M91_10783Ig-like domain-containing protein. (129 aa)
CDC26Anaphase-promoting complex subunit CDC26. (86 aa)
CDC16Cell division cycle protein 16-like protein. (607 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
TLN1Talin-1. (2541 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
ELK4ETS domain-containing protein Elk-4. (452 aa)
SPI1Transcription factor PU.1. (333 aa)
ANAPC1Anaphase promoting complex subunit 1. (1941 aa)
IL2RBInterleukin-2 receptor subunit beta. (659 aa)
E2F1E2F transcription factor 1. (360 aa)
CDC27Cell division cycle protein 27-like protein. (825 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
IL2RGCytokine receptor common subunit gamma. (379 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (303 aa)
JAK3Tyrosine-protein kinase. (1133 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1097 aa)
CDC23Cell division cycle protein 23-like protein. (597 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
EGR1Early growth response protein 1. (540 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (284 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (748 aa)
TBPTATA-box-binding protein. (312 aa)
XPO1Exportin-1. (1071 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
ANAPC11Anaphase-promoting complex subunit 11. (84 aa)
M91_12975Ig-like domain-containing protein. (341 aa)
CRTC2CREB-regulated transcription coactivator 2. (693 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
Server load: low (16%) [HD]