STRINGSTRING
RRAS2 RRAS2 SRC SRC GAB1 GAB1 MTOR MTOR CASP3 CASP3 WNT3 WNT3 CTSV CTSV SDC2 SDC2 ANK1 ANK1 WNT11 WNT11 WNT2B WNT2B EZR EZR VAV3 VAV3 TFAP4 TFAP4 IL12B IL12B WNT8B WNT8B RRAS RRAS IGF1R IGF1R FASLG FASLG FLNB FLNB HCLS1 HCLS1 COL1A2 COL1A2 RPS6KB1 RPS6KB1 GPC3 GPC3 MMP9 MMP9 SDC1 SDC1 PPP1R12A PPP1R12A CCND1 CCND1 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 CTTN CTTN NRAS NRAS MRAS MRAS PIK3CB PIK3CB IQGAP1 IQGAP1 SMAD2 SMAD2 KDR KDR FZD9 FZD9 MYC MYC TGFB2 TGFB2 DDX5 DDX5 GRB2 GRB2 PTPN11 PTPN11 TLR2 TLR2 CD44 CD44 NANOG-2 NANOG-2 TLR4 TLR4 HPSE HPSE PTPN6 PTPN6 ARHGEF12 ARHGEF12 PIK3R1 PIK3R1 IGF1 IGF1 MMP2 MMP2 FZD5 FZD5 NUDT16L1 NUDT16L1 CBL CBL ITGB5 ITGB5 FZD3 FZD3 RAF1 RAF1 FGFR1 FGFR1 MDM2 MDM2 TIAM1 TIAM1 VEGFA VEGFA CAV3 CAV3 CAMK2A CAMK2A FZD1 FZD1 CDKN1A CDKN1A DROSHA DROSHA PLAU PLAU PPP1CB PPP1CB PTK2 PTK2 MAPK13 MAPK13 HSPB2 HSPB2 WNT3A WNT3A MAPK14 MAPK14 TNF TNF CAV2 CAV2 FLNA FLNA CAV1 CAV1 MET MET WNT2 WNT2 FGF2 FGF2 RHOA RHOA PDPK1 PDPK1 HBEGF HBEGF CDC42 CDC42 LOC102269868 LOC102269868 RPS6 RPS6 PTCH1 PTCH1 HOXD10 HOXD10 ITGB1 ITGB1 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 ITPR1 ITPR1 TIMP3 TIMP3 STAT3 STAT3 PIK3CA PIK3CA FAS FAS SLC9A1 SLC9A1 SHH SHH CTNNB1 CTNNB1 ERBB3 ERBB3 WNT7A WNT7A LOC102282640 LOC102282640 PDCD4 PDCD4 HGF HGF FZD7 FZD7 CD63 CD63 ROCK2 ROCK2 PPP1R12B PPP1R12B PLCE1 PLCE1 CTSL CTSL PLAUR PLAUR FRS2 FRS2 MAP2K2 MAP2K2 PIK3R3 PIK3R3 PRKACA PRKACA FZD4 FZD4 VTN VTN ITGA2 ITGA2 KRAS KRAS FZD2 FZD2 HPSE2 HPSE2 IGF2 IGF2 PLCG2 PLCG2 ITGA5 ITGA5 PPP1CC PPP1CC HSPG2 HSPG2 ANK2 ANK2 ACTB ACTB SDC4 SDC4 SOS2 SOS2 PPP1CA PPP1CA RPS6KB2 RPS6KB2 TP53 TP53 ROCK1 ROCK1 MSN MSN ANK3 ANK3 COL1A1 COL1A1 ENSBMUP00000030233 ENSBMUP00000030233 ENSBMUP00000030236 ENSBMUP00000030236 ITPR2 ITPR2 EIF4B EIF4B ESR1 ESR1 ITGAV ITGAV WNT1 WNT1 FLNC FLNC FN1 FN1 TGFB1 TGFB1 SMO SMO TWIST2 TWIST2 PAK1 PAK1 FZD10 FZD10 PRKACB PRKACB WNT16 WNT16 PRKCG PRKCG ITGB3 ITGB3 HIF1A HIF1A VAV1 VAV1 PRKCA PRKCA PIK3R2 PIK3R2 WNT8A WNT8A ARAF ARAF ELK1 ELK1 WNT10A WNT10A FZD6 FZD6 IHH IHH MAPK3 MAPK3 AKT1 AKT1 ACTG1 ACTG1 PLCG1 PLCG1 RDX RDX ERBB4 ERBB4 DCN DCN LUM LUM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRAS2Ras-related protein R-Ras2. (173 aa)
SRCTyrosine-protein kinase. (559 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
CASP3Caspase 3. (276 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CTSVCathepsin L1; Belongs to the peptidase C1 family. (334 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (467 aa)
ANK1Ankyrin 1. (1877 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
EZREzrin. (659 aa)
VAV3Guanine nucleotide exchange factor VAV3. (874 aa)
TFAP4Transcription factor AP-4. (335 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
RRASRas-related protein R-Ras. (218 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (277 aa)
FLNBFilamin-B. (2633 aa)
HCLS1Hematopoietic lineage cell-specific protein. (485 aa)
COL1A2Collagen alpha-2(I) chain. (1364 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
MMP9Matrix metalloproteinase-9. (712 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (283 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1067 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
CTTNSrc substrate cortactin. (536 aa)
NRASGTPase NRas. (189 aa)
MRASRas-related protein M-Ras. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1627 aa)
SMAD2Mothers against decapentaplegic homolog. (468 aa)
KDRKinase insert domain protein receptor. (1353 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DDX5Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (746 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (800 aa)
CD44CD44 antigen. (703 aa)
NANOG-2Homeobox protein NANOG. (300 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (801 aa)
HPSEHeparanase. (508 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (597 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1549 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
MMP272 kDa type IV collagenase. (661 aa)
FZD5Frizzled class receptor 5. (545 aa)
NUDT16L1Nudix hydrolase 16 like 1. (202 aa)
CBLE3 ubiquitin-protein ligase CBL. (906 aa)
ITGB5Integrin beta. (786 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
FGFR1Basic fibroblast growth factor receptor 1. (852 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1. (1591 aa)
VEGFAVascular endothelial growth factor A. (197 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (650 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
DROSHARibonuclease 3. (1375 aa)
PLAUUrokinase-type plasminogen activator. (433 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PTK2Focal adhesion kinase 1. (1065 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
HSPB2Heat shock protein beta-2; Belongs to the small heat shock protein (HSP20) family. (182 aa)
WNT3AWingless-type MMTV integration site family, member 3. (348 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
FLNAFilamin-A. (2647 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
METHepatocyte growth factor receptor. (1384 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
RHOATransforming protein RhoA. (193 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
RPS640S ribosomal protein S6. (249 aa)
PTCH1Protein patched-like protein 1. (1459 aa)
HOXD10Homeobox protein Hox-D10. (340 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (814 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
TIMP3Metalloproteinase inhibitor 3. (318 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FASTumor necrosis factor receptor superfamily member 6. (323 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (818 aa)
SHHSonic hedgehog protein. (453 aa)
CTNNB1Catenin beta-1. (781 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1336 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC102282640Tetraspanin. (260 aa)
PDCD4Programmed cell death protein 4. (469 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (705 aa)
FZD7Frizzled class receptor 7. (558 aa)
CD63Tetraspanin. (237 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1297 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit 12B. (502 aa)
PLCE1Phosphoinositide phospholipase C. (1785 aa)
CTSLCathepsin L1; Belongs to the peptidase C1 family. (330 aa)
PLAURUrokinase plasminogen activator surface receptor. (330 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
VTNVitronectin. (476 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1189 aa)
KRASGTPase KRas. (189 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (515 aa)
HPSE2Heparanase-2. (389 aa)
IGF2Insulin-like growth factor II. (261 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1051 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
HSPG2Basement membrane-specific heparan sulfate proteoglycan core protein. (4334 aa)
ANK2Ankyrin-2. (3955 aa)
ACTBActin, cytoplasmic 1. (375 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (118 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
MSNMoesin. (577 aa)
ANK3Ankyrin-3. (4368 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
ENSBMUP00000030233Wingless-type MMTV integration site family, member 7. (190 aa)
ENSBMUP00000030236Wingless-type MMTV integration site family, member 7. (154 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
EIF4BEukaryotic translation initiation factor 4B. (615 aa)
ESR1Estrogen receptor. (310 aa)
ITGAVIntegrin subunit alpha V. (986 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
FLNCFilamin-C. (2720 aa)
FN1Fibronectin. (2598 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMOSmoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
TWIST2Twist-related protein 2. (160 aa)
PAK1Non-specific serine/threonine protein kinase. (552 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
ITGB3Integrin beta. (788 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
VAV1Proto-oncogene vav. (844 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
WNT10AWingless-type MMTV integration site family, member 10. (393 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
IHHIndian hedgehog protein. (411 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
RDXRadixin. (604 aa)
ERBB4Receptor tyrosine-protein kinase erbB-4. (804 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
LUMLumican. (342 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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