STRINGSTRING
GSK3B GSK3B GADD45G GADD45G LOC102276866 LOC102276866 DCC DCC MTOR MTOR CASP3 CASP3 EREG EREG AREG AREG MSH3 MSH3 APC APC BCL2 BCL2 APC2 APC2 RALA RALA BBC3 BBC3 RALGDS RALGDS RPS6KB1 RPS6KB1 MLH1 MLH1 MSH2 MSH2 MSH6 MSH6 CCND1 CCND1 MAP2K1 MAP2K1 SMAD3 SMAD3 HRAS HRAS SOS1 SOS1 TGFBR1 TGFBR1 NRAS NRAS PIK3CB PIK3CB SMAD2 SMAD2 FOS FOS MYC MYC TGFB2 TGFB2 GRB2 GRB2 BAK1 BAK1 BIRC5 BIRC5 PIK3R1 PIK3R1 GADD45A GADD45A RAF1 RAF1 POLK POLK MAPK9 MAPK9 LOC102277620 LOC102277620 CDKN1A CDKN1A APPL1 APPL1 GADD45B GADD45B PMAIP1 PMAIP1 RHOA RHOA BAD BAD LOC102269868 LOC102269868 AKT2 AKT2 TGFBR2 TGFBR2 TCF7L2 TCF7L2 PIK3CA PIK3CA CTNNB1 CTNNB1 LEF1 LEF1 MAP2K2 MAP2K2 PIK3R3 PIK3R3 RALB RALB TGFA TGFA KRAS KRAS MAPK8 MAPK8 SOS2 SOS2 RPS6KB2 RPS6KB2 TP53 TP53 MAPK10 MAPK10 TGFB1 TGFB1 DDB2 DDB2 SMAD4 SMAD4 AXIN1 AXIN1 LOC106700494 LOC106700494 RAC2 RAC2 CASP9 CASP9 TCF7L1 TCF7L1 AXIN2 AXIN2 PIK3R2 PIK3R2 ARAF ARAF MAPK3 MAPK3 AKT1 AKT1 LOC102277261 LOC102277261
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
LOC102276866Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
DCCNetrin receptor DCC. (1446 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
CASP3Caspase 3. (276 aa)
EREGProepiregulin. (169 aa)
AREGAmphiregulin. (269 aa)
MSH3DNA mismatch repair protein MSH3. (1016 aa)
APCAdenomatous polyposis coli protein. (2879 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
APC2Adenomatous polyposis coli protein 2. (2316 aa)
RALARas-related protein Ral-A. (206 aa)
BBC3Bcl-2-binding component 3. (131 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (874 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
MLH1DNA mismatch repair protein MLH1. (703 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SMAD2Mothers against decapentaplegic homolog. (468 aa)
FOSProto-oncogene c-Fos. (380 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
POLKDNA polymerase kappa. (910 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC102277620Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
RHOATransforming protein RhoA. (193 aa)
BADBcl2 antagonist of cell death. (168 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CTNNB1Catenin beta-1. (781 aa)
LEF1Lymphoid enhancer-binding factor 1. (414 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RALBRas-related protein Ral-B. (234 aa)
TGFATransforming growth factor, alpha. (160 aa)
KRASGTPase KRas. (189 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DDB2DNA damage-binding protein 2. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
AXIN1Axin-1. (865 aa)
LOC106700494Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (414 aa)
TCF7L1Transcription factor 7-like 1. (575 aa)
AXIN2Axin-2. (771 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
LOC102277261Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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