STRINGSTRING
GSK3B GSK3B GADD45G GADD45G CDH1 CDH1 APC APC APC2 APC2 CTNNA2 CTNNA2 MLH1 MLH1 CCND1 CCND1 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 PTEN PTEN NRAS NRAS PIK3CB PIK3CB MYC MYC GRB2 GRB2 BAK1 BAK1 PIK3R1 PIK3R1 GADD45A GADD45A RAF1 RAF1 POLK POLK CDKN1A CDKN1A ILK ILK GADD45B GADD45B CTNNA1 CTNNA1 BAD BAD PDPK1 PDPK1 LOC102269868 LOC102269868 AKT2 AKT2 TCF7L2 TCF7L2 PIK3CA PIK3CA CTNNB1 CTNNB1 LEF1 LEF1 MAP2K2 MAP2K2 PIK3R3 PIK3R3 FOXO3 FOXO3 KRAS KRAS LOC102275069 LOC102275069 SOS2 SOS2 TP53 TP53 DDB2 DDB2 AXIN1 AXIN1 CASP9 CASP9 TCF7L1 TCF7L1 AXIN2 AXIN2 PIK3R2 PIK3R2 ARAF ARAF ELK1 ELK1 MAPK3 MAPK3 AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
APCAdenomatous polyposis coli protein. (2879 aa)
APC2Adenomatous polyposis coli protein 2. (2316 aa)
CTNNA2Catenin alpha-2. (953 aa)
MLH1DNA mismatch repair protein MLH1. (703 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
POLKDNA polymerase kappa. (910 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
ILKIntegrin-linked protein kinase. (452 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
CTNNA1Catenin alpha-1. (906 aa)
BADBcl2 antagonist of cell death. (168 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CTNNB1Catenin beta-1. (781 aa)
LEF1Lymphoid enhancer-binding factor 1. (414 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FOXO3Forkhead box protein O3. (453 aa)
KRASGTPase KRas. (189 aa)
LOC102275069Catenin alpha-3. (391 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
DDB2DNA damage-binding protein 2. (426 aa)
AXIN1Axin-1. (865 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (414 aa)
TCF7L1Transcription factor 7-like 1. (575 aa)
AXIN2Axin-2. (771 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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