STRINGSTRING
GSK3B GSK3B PDGFB PDGFB ATF4 ATF4 IKBKB IKBKB MTOR MTOR RELA RELA RB1 RB1 PLAT PLAT CCNE2 CCNE2 CREBBP CREBBP BCL2 BCL2 NFKBIA NFKBIA IGF1R IGF1R ERG ERG MMP9 MMP9 CCND1 CCND1 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 PTEN PTEN NRAS NRAS CCNE1 CCNE1 PIK3CB PIK3CB IL1R2 IL1R2 GRB2 GRB2 CDKN1B CDKN1B PIK3R1 PIK3R1 IGF1 IGF1 PDGFC PDGFC CREB1 CREB1 PDGFD PDGFD RAF1 RAF1 HSP90B1 HSP90B1 FGFR1 FGFR1 MDM2 MDM2 HSP90AB1 HSP90AB1 PDGFA PDGFA PDGFRB PDGFRB CDKN1A CDKN1A PLAU PLAU E2F3 E2F3 BAD BAD PDPK1 PDPK1 CREB3L2 CREB3L2 LOC102279723 LOC102279723 LOC102269868 LOC102269868 FGFR2 FGFR2 PDGFRA PDGFRA INSRR INSRR AKT2 AKT2 EP300 EP300 TCF7L2 TCF7L2 PIK3CA PIK3CA CTNNB1 CTNNB1 ETV5 ETV5 CHUK CHUK FOXO1 FOXO1 AR AR LEF1 LEF1 MAP2K2 MAP2K2 CREB3L3 CREB3L3 PIK3R3 PIK3R3 SRD5A2 SRD5A2 TMPRSS2 TMPRSS2 CREB5 CREB5 NFKB1 NFKB1 TGFA TGFA KRAS KRAS SOS2 SOS2 TP53 TP53 LOC102271929 LOC102271929 CREB3L1 CREB3L1 CREB3 CREB3 E2F1 E2F1 MMP3 MMP3 CASP9 CASP9 TCF7L1 TCF7L1 PIK3R2 PIK3R2 ARAF ARAF MAPK3 MAPK3 AKT1 AKT1 CREB3L4 CREB3L4 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
RELATranscription factor p65. (549 aa)
RB1Retinoblastoma-associated protein. (880 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (567 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
CREBBPCREB-binding protein. (2203 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ERGTranscriptional regulator ERG. (486 aa)
MMP9Matrix metalloproteinase-9. (712 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
CCNE1G1/S-specific cyclin-E1. (411 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL1R2Interleukin-1 receptor type 2. (400 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (377 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
HSP90B1Endoplasmin. (809 aa)
FGFR1Basic fibroblast growth factor receptor 1. (852 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
HSP90AB1Heat shock protein HSP 90-beta. (722 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (222 aa)
PDGFRBBeta-type platelet-derived growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
PLAUUrokinase-type plasminogen activator. (433 aa)
E2F3Transcription factor E2F3. (334 aa)
BADBcl2 antagonist of cell death. (168 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
LOC102279723Heat shock protein 90 alpha family class A member 1. (119 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EP300E1A binding protein p300. (2371 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CTNNB1Catenin beta-1. (781 aa)
ETV5Uncharacterized protein. (510 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
FOXO1Forkhead box protein O1. (468 aa)
ARAndrogen receptor. (853 aa)
LEF1Lymphoid enhancer-binding factor 1. (414 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3CAMP responsive element binding protein 3 like 3. (456 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
TMPRSS2Transmembrane protease serine 2; Belongs to the peptidase S1 family. (490 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
TGFATransforming growth factor, alpha. (160 aa)
KRASGTPase KRas. (189 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
LOC102271929Glutathione S-transferase P. (239 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
E2F1E2F transcription factor 1. (360 aa)
MMP3Stromelysin-1. (500 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (414 aa)
TCF7L1Transcription factor 7-like 1. (575 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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