31 items (Bos mutus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GADD45G	Growth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1. (393 aa)
	HRAS	HRas proto-oncogene, GTPase. (182 aa)
	NRAS	GTPase NRas. (189 aa)
	MYC	V-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
	PAX8	Paired box protein Pax-8. (457 aa)
	RXRB	Retinoic acid receptor RXR-beta. (529 aa)
	BAK1	Bcl-2-like protein antagonist/killer. (204 aa)
	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (530 aa)
	POLK	DNA polymerase kappa. (910 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (161 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
	NTRK1	Tyrosine-protein kinase receptor. (799 aa)
	RXRG	Retinoic acid receptor RXR-gamma. (463 aa)
	TCF7L2	Transcription factor 7-like 2. (536 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	LEF1	Lymphoid enhancer-binding factor 1. (414 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	NCOA4	Nuclear receptor coactivator 4. (631 aa)
	KRAS	GTPase KRas. (189 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
	CCDC6	Coiled-coil domain-containing protein 6. (474 aa)
	TPR	Nucleoprotein TPR. (2436 aa)
	DDB2	DNA damage-binding protein 2. (426 aa)
	TFG-2	PB1 domain-containing protein. (155 aa)
	TCF7L1	Transcription factor 7-like 1. (575 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	TP53	ENSBMUP00000011944	ENSBMUP00000028863	Bcl-2-like protein antagonist/killer.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.971
CCDC6	NCOA4	ENSBMUP00000028867	ENSBMUP00000026231	Coiled-coil domain-containing protein 6.	Nuclear receptor coactivator 4.	0.933
CCDC6	RET	ENSBMUP00000028867	ENSBMUP00000017013	Coiled-coil domain-containing protein 6.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.950
CCND1	CDH1	ENSBMUP00000007405	ENSBMUP00000002304	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	0.615
CCND1	CDKN1A	ENSBMUP00000007405	ENSBMUP00000016610	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Cyclin-dependent kinase inhibitor 1.	0.991
CCND1	CTNNB1	ENSBMUP00000007405	ENSBMUP00000022568	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Catenin beta-1.	0.679
CCND1	KRAS	ENSBMUP00000007405	ENSBMUP00000026628	G1/S-specific cyclin-D1; Belongs to the cyclin family.	GTPase KRas.	0.500
CCND1	LEF1	ENSBMUP00000007405	ENSBMUP00000024434	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Lymphoid enhancer-binding factor 1.	0.581
CCND1	MAPK3	ENSBMUP00000007405	ENSBMUP00000035411	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.525
CCND1	PPARG	ENSBMUP00000007405	ENSBMUP00000014722	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.510
CCND1	TP53	ENSBMUP00000007405	ENSBMUP00000028863	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.625
CDH1	CCND1	ENSBMUP00000002304	ENSBMUP00000007405	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.615
CDH1	CTNNB1	ENSBMUP00000002304	ENSBMUP00000022568	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Catenin beta-1.	0.999
CDH1	KRAS	ENSBMUP00000002304	ENSBMUP00000026628	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	GTPase KRas.	0.588
CDH1	LEF1	ENSBMUP00000002304	ENSBMUP00000024434	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Lymphoid enhancer-binding factor 1.	0.518
CDH1	TP53	ENSBMUP00000002304	ENSBMUP00000028863	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.507
CDKN1A	CCND1	ENSBMUP00000016610	ENSBMUP00000007405	Cyclin-dependent kinase inhibitor 1.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.991
CDKN1A	DDB2	ENSBMUP00000016610	ENSBMUP00000031755	Cyclin-dependent kinase inhibitor 1.	DNA damage-binding protein 2.	0.526
CDKN1A	GADD45A	ENSBMUP00000016610	ENSBMUP00000013634	Cyclin-dependent kinase inhibitor 1.	Growth arrest and DNA damage-inducible protein GADD45 alpha.	0.722
CDKN1A	GADD45B	ENSBMUP00000016610	ENSBMUP00000017697	Cyclin-dependent kinase inhibitor 1.	Growth arrest and DNA damage-inducible protein GADD45 beta.	0.517