STRINGSTRING
SRC SRC RB1 RB1 CDH1 CDH1 CXCL8 CXCL8 DAPK2 DAPK2 MMP9 MMP9 CCND1 CCND1 MAP2K1 MAP2K1 HRAS HRAS NRAS NRAS MYC MYC MMP2 MMP2 RAF1 RAF1 MDM2 MDM2 CDKN2A CDKN2A RPS6KA5 RPS6KA5 VEGFA VEGFA CDKN1A CDKN1A E2F3 E2F3 HBEGF HBEGF LOC102269868 LOC102269868 DAPK1 DAPK1 DAPK3 DAPK3 MAP2K2 MAP2K2 KRAS KRAS RASSF1 RASSF1 TP53 TP53 UPK3A UPK3A E2F1 E2F1 CDK4 CDK4 ARAF ARAF MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (559 aa)
RB1Retinoblastoma-associated protein. (880 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
DAPK2Protein kinase domain-containing protein. (488 aa)
MMP9Matrix metalloproteinase-9. (712 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
NRASGTPase NRas. (189 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
MMP272 kDa type IV collagenase. (661 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoform 4. (153 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (723 aa)
VEGFAVascular endothelial growth factor A. (197 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
E2F3Transcription factor E2F3. (334 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
DAPK1Death-associated protein kinase 1. (1430 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
KRASGTPase KRas. (189 aa)
RASSF1Ras association domain-containing protein 1. (344 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
UPK3AUroplakin-3a. (287 aa)
E2F1E2F transcription factor 1. (360 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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