STRINGSTRING
GADD45G GADD45G IKBKB IKBKB RELA RELA RB1 RB1 NFKBIA NFKBIA HDAC2 HDAC2 CCND1 CCND1 MAP2K1 MAP2K1 SMAD3 SMAD3 HRAS HRAS SOS1 SOS1 TGFBR1 TGFBR1 NRAS NRAS PIK3CB PIK3CB MYC MYC TGFB2 TGFB2 GRB2 GRB2 HDAC1 HDAC1 PTPN11 PTPN11 BAK1 BAK1 CDKN1B CDKN1B PIK3R1 PIK3R1 GADD45A GADD45A CBL CBL RAF1 RAF1 MDM2 MDM2 SHC1 SHC1 RUNX1 RUNX1 CTBP2 CTBP2 CDKN2A CDKN2A POLK POLK GAB2 GAB2 LOC102271380 LOC102271380 CDKN1A CDKN1A E2F3 E2F3 CDK6 CDK6 GADD45B GADD45B BAD BAD BCL2L1 BCL2L1 AKT2 AKT2 TGFBR2 TGFBR2 MECOM MECOM STAT5A STAT5A STAT5B STAT5B PIK3CA PIK3CA SHC3 SHC3 CHUK CHUK MAP2K2 MAP2K2 PIK3R3 PIK3R3 CRKL CRKL NFKB1 NFKB1 KRAS KRAS SOS2 SOS2 TP53 TP53 SHC4 SHC4 TGFB1 TGFB1 DDB2 DDB2 SMAD4 SMAD4 CTBP1 CTBP1 E2F1 E2F1 CDK4 CDK4 PIK3R2 PIK3R2 ARAF ARAF MAPK3 MAPK3 AKT1 AKT1 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
RELATranscription factor p65. (549 aa)
RB1Retinoblastoma-associated protein. (880 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
HDAC2Histone deacetylase 1/2. (488 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
HDAC1Histone deacetylase 1. (482 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
CBLE3 ubiquitin-protein ligase CBL. (906 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
SHC1SHC-transforming protein 1. (501 aa)
RUNX1Runt-related transcription factor 1. (491 aa)
CTBP2C-terminal binding protein 2. (973 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoform 4. (153 aa)
POLKDNA polymerase kappa. (910 aa)
GAB2GRB2-associated-binding protein 2. (666 aa)
LOC102271380Uncharacterized protein. (174 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
E2F3Transcription factor E2F3. (334 aa)
CDK6Cell division protein kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
BADBcl2 antagonist of cell death. (168 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MECOMUncharacterized protein. (1230 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription 5B. (787 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
SHC3SHC-transforming protein 3. (105 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CRKLCrk-like protein. (302 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
KRASGTPase KRas. (189 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
SHC4SHC-transforming protein 4. (630 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DDB2DNA damage-binding protein 2. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
CTBP12-Hacid_dh_C domain-containing protein. (337 aa)
E2F1E2F transcription factor 1. (360 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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