STRINGSTRING
GSK3B GSK3B GADD45G GADD45G MTOR MTOR RB1 RB1 WNT3 WNT3 NFKB2 NFKB2 WNT11 WNT11 WNT2B WNT2B FGF8 FGF8 TNFSF11 TNFSF11 APC APC LOC102269709 LOC102269709 WNT8B WNT8B APC2 APC2 IGF1R IGF1R LRP5L LRP5L RPS6KB1 RPS6KB1 CCND1 CCND1 FGF3 FGF3 MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 NCOA1 NCOA1 PTEN PTEN NRAS NRAS PIK3CB PIK3CB FOS FOS FZD9 FZD9 MYC MYC NCOA3 NCOA3 GRB2 GRB2 HEY1 HEY1 BAK1 BAK1 LRP6 LRP6 LOC102283373 LOC102283373 PIK3R1 PIK3R1 IGF1 IGF1 FZD5 FZD5 GADD45A GADD45A FZD3 FZD3 RAF1 RAF1 FGFR1 FGFR1 SHC1 SHC1 FGF18 FGF18 POLK POLK FLT4 FLT4 NOTCH2 NOTCH2 FZD1 FZD1 CDKN1A CDKN1A E2F3 E2F3 FGF17 FGF17 WNT3A WNT3A CDK6 CDK6 HEY2 HEY2 GADD45B GADD45B ESR2 ESR2 BRCA2 BRCA2 HEYL HEYL WNT2 WNT2 FGF2 FGF2 CSNK1A1 CSNK1A1 LOC102269868 LOC102269868 AKT2 AKT2 FGF21 FGF21 TCF7L2 TCF7L2 PIK3CA PIK3CA CTNNB1 CTNNB1 WNT7A WNT7A FGF16 FGF16 SHC3 SHC3 FZD7 FZD7 DLL4 DLL4 LEF1 LEF1 MAP2K2 MAP2K2 PIK3R3 PIK3R3 FGF5 FGF5 FZD4 FZD4 FGF9 FGF9 KRAS KRAS BRCA1 BRCA1 FZD2 FZD2 KIT KIT SOS2 SOS2 RPS6KB2 RPS6KB2 TP53 TP53 SP1 SP1 ENSBMUP00000030233 ENSBMUP00000030233 ENSBMUP00000030236 ENSBMUP00000030236 SHC4 SHC4 FGF7 FGF7 ESR1 ESR1 FGF10 FGF10 WNT1 WNT1 NOTCH4 NOTCH4 DDB2 DDB2 FZD10 FZD10 DVL1 DVL1 AXIN1 AXIN1 WNT16 WNT16 FGF20 FGF20 JAG1 JAG1 E2F1 E2F1 CDK4 CDK4 TCF7L1 TCF7L1 AXIN2 AXIN2 PIK3R2 PIK3R2 WNT8A WNT8A ARAF ARAF FGF6 FGF6 WNT10A WNT10A FZD6 FZD6 DLL1 DLL1 MAPK3 MAPK3 AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
RB1Retinoblastoma-associated protein. (880 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (244 aa)
APCAdenomatous polyposis coli protein. (2879 aa)
LOC102269709Casein kinase I isoform beta. (86 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
APC2Adenomatous polyposis coli protein 2. (2316 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LRP5LLow-density lipoprotein receptor-related protein 5. (251 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
NCOA3Nuclear receptor coactivator 3. (1412 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1. (304 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1613 aa)
LOC102283373Casein kinase I isoform beta; Belongs to the protein kinase superfamily. (336 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IGF1Insulin-like growth factor I. (194 aa)
FZD5Frizzled class receptor 5. (545 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
FGFR1Basic fibroblast growth factor receptor 1. (852 aa)
SHC1SHC-transforming protein 1. (501 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
POLKDNA polymerase kappa. (910 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
NOTCH2Uncharacterized protein. (2471 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (650 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
E2F3Transcription factor E2F3. (334 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
WNT3AWingless-type MMTV integration site family, member 3. (348 aa)
CDK6Cell division protein kinase 6; Belongs to the protein kinase superfamily. (326 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
ESR2Estrogen receptor beta. (527 aa)
BRCA2Breast cancer 2 susceptibility protein. (3374 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (301 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (218 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SHC3SHC-transforming protein 3. (105 aa)
FZD7Frizzled class receptor 7. (558 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (707 aa)
LEF1Lymphoid enhancer-binding factor 1. (414 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (125 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KRASGTPase KRas. (189 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1828 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (515 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
SP1Transcription factor Sp1. (779 aa)
ENSBMUP00000030233Wingless-type MMTV integration site family, member 7. (190 aa)
ENSBMUP00000030236Wingless-type MMTV integration site family, member 7. (154 aa)
SHC4SHC-transforming protein 4. (630 aa)
FGF7Fibroblast growth factor 7. (194 aa)
ESR1Estrogen receptor. (310 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
NOTCH4Notch 4. (642 aa)
DDB2DNA damage-binding protein 2. (426 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
DVL1Segment polarity protein dishevelled-like protein DVL-1. (691 aa)
AXIN1Axin-1. (865 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
E2F1E2F transcription factor 1. (360 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (303 aa)
TCF7L1Transcription factor 7-like 1. (575 aa)
AXIN2Axin-2. (771 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT10AWingless-type MMTV integration site family, member 10. (393 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (687 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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