STRINGSTRING
GSK3B GSK3B GADD45G GADD45G GAB1 GAB1 DPF1 DPF1 MTOR MTOR NQO1 NQO1 ACTL6B ACTL6B RB1 RB1 WNT3 WNT3 WNT11 WNT11 WNT2B WNT2B SMARCA4 SMARCA4 LOC102274807 LOC102274807 APC APC GSTM3 GSTM3 LOC102269709 LOC102269709 WNT8B WNT8B APC2 APC2 SMARCE1 SMARCE1 IGF1R IGF1R TXNRD2 TXNRD2 LRP5L LRP5L RPS6KB1 RPS6KB1 CCND1 CCND1 GSTO2 GSTO2 MAP2K1 MAP2K1 GSTO1 GSTO1 PBRM1 PBRM1 MGST1 MGST1 SMAD3 SMAD3 HRAS HRAS SOS1 SOS1 ARID2 ARID2 TGFBR1 TGFBR1 SMARCD2 SMARCD2 PTEN PTEN NRAS NRAS PIK3CB PIK3CB SMAD2 SMAD2 GSTA3 GSTA3 TXNRD1 TXNRD1 FZD9 FZD9 MYC MYC TGFB2 TGFB2 GRB2 GRB2 BAK1 BAK1 LRP6 LRP6 LOC102283373 LOC102283373 DPF3 DPF3 PIK3R1 PIK3R1 FZD5 FZD5 GADD45A GADD45A FZD3 FZD3 RAF1 RAF1 SHC1 SHC1 MGST2 MGST2 PHF10 PHF10 CDKN2A CDKN2A POLK POLK LOC102271380 LOC102271380 FZD1 FZD1 CDKN1A CDKN1A E2F3 E2F3 SMARCC1 SMARCC1 WNT3A WNT3A CDK6 CDK6 GADD45B GADD45B KEAP1 KEAP1 MET MET HMOX1 HMOX1 WNT2 WNT2 BAD BAD SMARCD1 SMARCD1 CSNK1A1 CSNK1A1 BCL2L1 BCL2L1 LOC102269868 LOC102269868 AKT2 AKT2 MGST3 MGST3 TGFBR2 TGFBR2 TCF7L2 TCF7L2 PIK3CA PIK3CA ARID1A ARID1A TXNRD3 TXNRD3 ACTL6A ACTL6A CTNNB1 CTNNB1 WNT7A WNT7A SHC3 SHC3 HGF HGF FZD7 FZD7 LEF1 LEF1 MAP2K2 MAP2K2 PIK3R3 PIK3R3 FZD4 FZD4 TGFA TGFA KRAS KRAS FZD2 FZD2 IGF2 IGF2 PLCG2 PLCG2 ACTB ACTB SOS2 SOS2 SMARCD3 SMARCD3 RPS6KB2 RPS6KB2 TP53 TP53 GSTA4 GSTA4 LOC102271929 LOC102271929 ENSBMUP00000030233 ENSBMUP00000030233 ENSBMUP00000030236 ENSBMUP00000030236 SHC4 SHC4 LOC102276661 LOC102276661 GSTT4 GSTT4 SMARCB1 SMARCB1 WNT1 WNT1 TGFB1 TGFB1 DDB2 DDB2 FZD10 FZD10 SMAD4 SMAD4 DVL1 DVL1 AXIN1 AXIN1 WNT16 WNT16 NFE2L2 NFE2L2 E2F1 E2F1 PRKCG PRKCG CDK4 CDK4 TCF7L1 TCF7L1 LOC102287938 LOC102287938 AXIN2 AXIN2 PRKCA PRKCA PIK3R2 PIK3R2 WNT8A WNT8A BRD7 BRD7 ARAF ARAF ELK1 ELK1 WNT10A WNT10A FZD6 FZD6 MAPK3 MAPK3 AKT1 AKT1 ACTG1 ACTG1 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
DPF1Zinc finger protein neuro-d4. (414 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1. (274 aa)
ACTL6BActin-like protein 6B; Belongs to the actin family. (426 aa)
RB1Retinoblastoma-associated protein. (880 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
SMARCA4Transcription activator BRG1. (1641 aa)
LOC102274807Glutathione S-transferase A1. (172 aa)
APCAdenomatous polyposis coli protein. (2879 aa)
GSTM3Glutathione S-transferase. (225 aa)
LOC102269709Casein kinase I isoform beta. (86 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
APC2Adenomatous polyposis coli protein 2. (2316 aa)
SMARCE1SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1. (415 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TXNRD2Thioredoxin reductase 2, mitochondrial. (493 aa)
LRP5LLow-density lipoprotein receptor-related protein 5. (251 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
GSTO2Glutathione S-transferase omega-2; Belongs to the GST superfamily. (244 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
GSTO1Glutathione S-transferase omega-1. (344 aa)
PBRM1Protein polybromo-1. (1688 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
ARID2AT-rich interactive domain-containing protein 2. (1834 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
SMARCD2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2. (689 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SMAD2Mothers against decapentaplegic homolog. (468 aa)
GSTA3Glutathione S-transferase. (222 aa)
TXNRD1Thioredoxin reductase (NADPH). (564 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1613 aa)
LOC102283373Casein kinase I isoform beta; Belongs to the protein kinase superfamily. (336 aa)
DPF3Zinc finger protein DPF3. (378 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
FZD5Frizzled class receptor 5. (545 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
SHC1SHC-transforming protein 1. (501 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
PHF10PHD finger protein 10. (498 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoform 4. (153 aa)
POLKDNA polymerase kappa. (910 aa)
LOC102271380Uncharacterized protein. (174 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (650 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
E2F3Transcription factor E2F3. (334 aa)
SMARCC1SWI/SNF complex subunit SMARCC1. (1105 aa)
WNT3AWingless-type MMTV integration site family, member 3. (348 aa)
CDK6Cell division protein kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
METHepatocyte growth factor receptor. (1384 aa)
HMOX1Heme oxygenase 1. (289 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BADBcl2 antagonist of cell death. (168 aa)
SMARCD1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1. (568 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (218 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
ARID1AAT-rich interactive domain-containing protein 1A. (2283 aa)
TXNRD3Thioredoxin reductase 3. (615 aa)
ACTL6AActin-like protein 6A; Belongs to the actin family. (429 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SHC3SHC-transforming protein 3. (105 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (705 aa)
FZD7Frizzled class receptor 7. (558 aa)
LEF1Lymphoid enhancer-binding factor 1. (414 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
TGFATransforming growth factor, alpha. (160 aa)
KRASGTPase KRas. (189 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (515 aa)
IGF2Insulin-like growth factor II. (261 aa)
PLCG2Phosphoinositide phospholipase C. (1240 aa)
ACTBActin, cytoplasmic 1. (375 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (429 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
GSTA4Glutathione S-transferase A4. (251 aa)
LOC102271929Glutathione S-transferase P. (239 aa)
ENSBMUP00000030233Wingless-type MMTV integration site family, member 7. (190 aa)
ENSBMUP00000030236Wingless-type MMTV integration site family, member 7. (154 aa)
SHC4SHC-transforming protein 4. (630 aa)
LOC102276661Glutathione S-transferase theta-1; Belongs to the GST superfamily. (598 aa)
GSTT4Glutathione S-transferase theta-4. (247 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (359 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DDB2DNA damage-binding protein 2. (426 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
DVL1Segment polarity protein dishevelled-like protein DVL-1. (691 aa)
AXIN1Axin-1. (865 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2; Belongs to the bZIP family. (590 aa)
E2F1E2F transcription factor 1. (360 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (303 aa)
TCF7L1Transcription factor 7-like 1. (575 aa)
LOC102287938Glutathione S-transferase A2. (309 aa)
AXIN2Axin-2. (771 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BRD7Bromodomain-containing protein 7. (651 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
WNT10AWingless-type MMTV integration site family, member 10. (393 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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