STRINGSTRING
GSK3B GSK3B GADD45G GADD45G GAB1 GAB1 MTOR MTOR RB1 RB1 WNT3 WNT3 CDH1 CDH1 CDH17 CDH17 RARB RARB WNT11 WNT11 WNT2B WNT2B CCNE2 CCNE2 FGF8 FGF8 APC APC BCL2 BCL2 LOC102269709 LOC102269709 WNT8B WNT8B APC2 APC2 CTNNA2 CTNNA2 LRP5L LRP5L RPS6KB1 RPS6KB1 MLH1 MLH1 CCND1 CCND1 FGF3 FGF3 MAP2K1 MAP2K1 SMAD3 SMAD3 HRAS HRAS SOS1 SOS1 TGFBR1 TGFBR1 NRAS NRAS CCNE1 CCNE1 PIK3CB PIK3CB ABCB1 ABCB1 SMAD2 SMAD2 FZD9 FZD9 MYC MYC TGFB2 TGFB2 RXRB RXRB GRB2 GRB2 BAK1 BAK1 CDKN1B CDKN1B LRP6 LRP6 LOC102283373 LOC102283373 PIK3R1 PIK3R1 FZD5 FZD5 GADD45A GADD45A FZD3 FZD3 RAF1 RAF1 SHC1 SHC1 FGF18 FGF18 POLK POLK REG4 REG4 FZD1 FZD1 CDKN1A CDKN1A E2F3 E2F3 FGF17 FGF17 WNT3A WNT3A GADD45B GADD45B MET MET CTNNA1 CTNNA1 WNT2 WNT2 FGF2 FGF2 CSNK1A1 CSNK1A1 LOC102269868 LOC102269868 FGFR2 FGFR2 AKT2 AKT2 TGFBR2 TGFBR2 RXRG RXRG FGF21 FGF21 TCF7L2 TCF7L2 PIK3CA PIK3CA SHH SHH CTNNB1 CTNNB1 WNT7A WNT7A FGF16 FGF16 SHC3 SHC3 JUP JUP HGF HGF FZD7 FZD7 LEF1 LEF1 MAP2K2 MAP2K2 PIK3R3 PIK3R3 FGF5 FGF5 FZD4 FZD4 FGF9 FGF9 KRAS KRAS FZD2 FZD2 LOC102275069 LOC102275069 SOS2 SOS2 RPS6KB2 RPS6KB2 TP53 TP53 ENSBMUP00000030233 ENSBMUP00000030233 ENSBMUP00000030236 ENSBMUP00000030236 SHC4 SHC4 FGF7 FGF7 FGF10 FGF10 WNT1 WNT1 CDX2 CDX2 TGFB1 TGFB1 DDB2 DDB2 FZD10 FZD10 SMAD4 SMAD4 DVL1 DVL1 AXIN1 AXIN1 WNT16 WNT16 FGF20 FGF20 E2F1 E2F1 TCF7L1 TCF7L1 AXIN2 AXIN2 PIK3R2 PIK3R2 WNT8A WNT8A ARAF ARAF FGF6 FGF6 WNT10A WNT10A FZD6 FZD6 MAPK3 MAPK3 AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (265 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
RB1Retinoblastoma-associated protein. (880 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
CDH17Cadherin-17. (832 aa)
RARBRetinoic acid receptor beta. (304 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
APCAdenomatous polyposis coli protein. (2879 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
LOC102269709Casein kinase I isoform beta. (86 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
APC2Adenomatous polyposis coli protein 2. (2316 aa)
CTNNA2Catenin alpha-2. (953 aa)
LRP5LLow-density lipoprotein receptor-related protein 5. (251 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
MLH1DNA mismatch repair protein MLH1. (703 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (67 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
NRASGTPase NRas. (189 aa)
CCNE1G1/S-specific cyclin-E1. (411 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
ABCB1Multidrug resistance protein 1. (1004 aa)
SMAD2Mothers against decapentaplegic homolog. (468 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
MYCV-myc avian myelocytomatosis viral oncogene homolog. (436 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RXRBRetinoic acid receptor RXR-beta. (529 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BAK1Bcl-2-like protein antagonist/killer. (204 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1613 aa)
LOC102283373Casein kinase I isoform beta; Belongs to the protein kinase superfamily. (336 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
FZD5Frizzled class receptor 5. (545 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
SHC1SHC-transforming protein 1. (501 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
POLKDNA polymerase kappa. (910 aa)
REG4Regenerating islet-derived protein 4. (158 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (650 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
E2F3Transcription factor E2F3. (334 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
WNT3AWingless-type MMTV integration site family, member 3. (348 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (164 aa)
METHepatocyte growth factor receptor. (1384 aa)
CTNNA1Catenin alpha-1. (906 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (218 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RXRGRetinoic acid receptor RXR-gamma. (463 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
SHHSonic hedgehog protein. (453 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SHC3SHC-transforming protein 3. (105 aa)
JUPJunction plakoglobin. (745 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (705 aa)
FZD7Frizzled class receptor 7. (558 aa)
LEF1Lymphoid enhancer-binding factor 1. (414 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (125 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KRASGTPase KRas. (189 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (515 aa)
LOC102275069Catenin alpha-3. (391 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
ENSBMUP00000030233Wingless-type MMTV integration site family, member 7. (190 aa)
ENSBMUP00000030236Wingless-type MMTV integration site family, member 7. (154 aa)
SHC4SHC-transforming protein 4. (630 aa)
FGF7Fibroblast growth factor 7. (194 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
CDX2Homeobox protein CDX-2. (138 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DDB2DNA damage-binding protein 2. (426 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
DVL1Segment polarity protein dishevelled-like protein DVL-1. (691 aa)
AXIN1Axin-1. (865 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
E2F1E2F transcription factor 1. (360 aa)
TCF7L1Transcription factor 7-like 1. (575 aa)
AXIN2Axin-2. (771 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT10AWingless-type MMTV integration site family, member 10. (393 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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