STRINGSTRING
PDGFB PDGFB MTOR MTOR SLC22A1 SLC22A1 SLC22A2 SLC22A2 SLC22A3 SLC22A3 DGKH DGKH PLPP2 PLPP2 SLC44A2 SLC44A2 TSC1 TSC1 SLC44A4 SLC44A4 RALGDS RALGDS CHKA CHKA PLD2 PLD2 RPS6KB1 RPS6KB1 WAS WAS MAP2K1 MAP2K1 HRAS HRAS SOS1 SOS1 EIF4EBP1 EIF4EBP1 NRAS NRAS PLD1 PLD1 PIK3CB PIK3CB FOS FOS SLC5A7 SLC5A7 M91_02843 M91_02843 SLC44A1 SLC44A1 GRB2 GRB2 PLPP3 PLPP3 PIP5K1B PIP5K1B CHPT1 CHPT1 PIK3R1 PIK3R1 PDGFC PDGFC PDGFD PDGFD DGKE DGKE RAF1 RAF1 PDGFA PDGFA MAPK9 MAPK9 PDGFRB PDGFRB LYPLA1 LYPLA1 SLC22A5 SLC22A5 SLC22A4 SLC22A4 DGKI DGKI PDPK1 PDPK1 LOC102269868 LOC102269868 PDGFRA PDGFRA AKT2 AKT2 GPCPD1 GPCPD1 SLC44A5 SLC44A5 PCYT1B PCYT1B PIK3CA PIK3CA CHKB CHKB WASF2 WASF2 WASF1 WASF1 TSC2 TSC2 DGKA DGKA DGKG DGKG PIP5K1C PIP5K1C MAP2K2 MAP2K2 PIK3R3 PIK3R3 PLA2G4B PLA2G4B PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F KRAS KRAS MAPK8 MAPK8 DGKB DGKB PCYT1A PCYT1A SOS2 SOS2 RPS6KB2 RPS6KB2 MAPK10 MAPK10 SP1 SP1 PLA2G4A PLA2G4A PIP5K1A PIP5K1A RAC2 RAC2 DGKQ DGKQ PRKCG PRKCG DGKD DGKD HIF1A HIF1A PRKCA PRKCA PIK3R2 PIK3R2 SLC44A3 SLC44A3 MAPK3 MAPK3 AKT1 AKT1 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
SLC22A1Solute carrier family 22 member 1. (548 aa)
SLC22A2Solute carrier family 22 member 2. (549 aa)
SLC22A3Solute carrier family 22 member 3. (556 aa)
DGKHDiacylglycerol kinase (ATP). (1217 aa)
PLPP2Lipid phosphate phosphohydrolase 2. (300 aa)
SLC44A2Choline transporter-like protein 2; Belongs to the CTL (choline transporter-like) family. (711 aa)
TSC1Hamartin. (1159 aa)
SLC44A4Choline transporter-like protein 4; Belongs to the CTL (choline transporter-like) family. (670 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (874 aa)
CHKACholine kinase alpha. (457 aa)
PLD2Phospholipase. (933 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
WASWiskott-Aldrich syndrome protein. (514 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
NRASGTPase NRas. (189 aa)
PLD1Phospholipase. (1074 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSProto-oncogene c-Fos. (380 aa)
SLC5A7High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
SLC44A1Choline transporter-like protein 1; Belongs to the CTL (choline transporter-like) family. (615 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (311 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type-1 beta. (546 aa)
CHPT1Cholinephosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (338 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (377 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
DGKEDiacylglycerol kinase. (564 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (222 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PDGFRBBeta-type platelet-derived growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
LYPLA1Acyl-protein thioesterase 1. (164 aa)
SLC22A5Solute carrier family 22 member 5. (557 aa)
SLC22A4Solute carrier family 22 member 4. (551 aa)
DGKIDiacylglycerol kinase (ATP). (1075 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GPCPD1Glycerophosphocholine phosphodiesterase GPCPD1. (672 aa)
SLC44A5Choline transporter-like protein 5; Belongs to the CTL (choline transporter-like) family. (709 aa)
PCYT1BCholine-phosphate cytidylyltransferase B. (369 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CHKBCholine/ethanolamine kinase. (395 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2. (493 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
TSC2Tuberous sclerosis 2. (1812 aa)
DGKADiacylglycerol kinase (ATP). (729 aa)
DGKGDiacylglycerol kinase. (791 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type-1 gamma. (668 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PLA2G4BPhospholipase A2. (784 aa)
PLA2G4EPhospholipase A2. (860 aa)
PLA2G4DPhospholipase A2. (808 aa)
PLA2G4FPhospholipase A2. (844 aa)
KRASGTPase KRas. (189 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
DGKBDiacylglycerol kinase. (803 aa)
PCYT1ACholine-phosphate cytidylyltransferase A. (381 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
SP1Transcription factor Sp1. (779 aa)
PLA2G4APhospholipase A2. (749 aa)
PIP5K1APutative PIP5K1A and PSMD4-like protein. (562 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
DGKQDiacylglycerol kinase. (844 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
DGKDDiacylglycerol kinase (ATP). (1183 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
PRKCAProtein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (614 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
SLC44A3Choline transporter-like protein 3; Belongs to the CTL (choline transporter-like) family. (602 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.