STRINGSTRING
RASGRP1 RASGRP1 IKBKB IKBKB PRKCQ PRKCQ MTOR MTOR RELA RELA CSNK2A2 CSNK2A2 JAK1 JAK1 NFATC3 NFATC3 NFKBIA NFKBIA M91_00611 M91_00611 BATF2 BATF2 CD274 CD274 JAK2 JAK2 RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 BATF3 BATF3 HRAS HRAS PTEN PTEN NRAS NRAS PIK3CB PIK3CB MAP3K3 MAP3K3 FOS FOS BATF BATF TLR9 TLR9 IFNGR2 IFNGR2 PTPN11 PTPN11 TLR2 TLR2 TRAF6 TRAF6 CD4 CD4 M91_15255 M91_15255 TLR4 TLR4 M91_06422 M91_06422 PTPN6 PTPN6 PIK3R1 PIK3R1 TICAM1 TICAM1 RAF1 RAF1 NFKBIE NFKBIE IFNG IFNG IFNGR1 IFNGR1 CD3G CD3G CD3D CD3D CD3E CD3E ALK ALK MAPK13 MAPK13 MAPK14 MAPK14 PPP3CC PPP3CC CSNK2B CSNK2B TICAM2 TICAM2 NFKBIB NFKBIB PPP3CA PPP3CA LOC102269868 LOC102269868 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 STAT1 STAT1 CSNK2A1 CSNK2A1 MAP2K3 MAP2K3 STAT3 STAT3 PIK3CA PIK3CA CHUK CHUK MYD88 MYD88 LOC102285474 LOC102285474 MAP2K2 MAP2K2 PIK3R3 PIK3R3 CD28 CD28 NFKB1 NFKB1 KRAS KRAS PPP3R1 PPP3R1 RPS6KB2 RPS6KB2 MAP2K6 MAP2K6 M91_10783 M91_10783 EML4 EML4 ZAP70 ZAP70 HIF1A HIF1A PIK3R2 PIK3R2 MAPK3 MAPK3 AKT1 AKT1 PLCG1 PLCG1 PPP3CB PPP3CB IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASGRP1RAS guanyl-releasing protein 1. (797 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
RELATranscription factor p65. (549 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
JAK1Janus kinase 1. (1158 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1038 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
M91_00611IGv domain-containing protein. (140 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2. (275 aa)
CD274Programmed cell death 1 ligand 1. (289 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
BATF3Basic leucine zipper transcriptional factor ATF-like 3. (125 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASGTPase NRas. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
FOSProto-oncogene c-Fos. (380 aa)
BATFBasic leucine zipper transcriptional factor ATF-like protein. (125 aa)
TLR9Toll like receptor 9. (1006 aa)
IFNGR2Interferon gamma receptor 2. (363 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (800 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
CD4T-cell surface glycoprotein CD4. (455 aa)
M91_15255Ig-like domain-containing protein. (165 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (801 aa)
M91_06422Ig-like domain-containing protein. (132 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (597 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
TICAM1Toll like receptor adaptor molecule 1. (688 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
NFKBIENF-kappa-B inhibitor epsilon. (362 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (175 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (172 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (197 aa)
ALKTyrosine-protein kinase receptor. (528 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
PPP3CCSerine/threonine-protein phosphatase. (587 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
TICAM2Toll like receptor adaptor molecule 2. (121 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LOC102269868Receptor protein-tyrosine kinase. (722 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
STAT1Signal transducer and activator of transcription. (817 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
MYD88Myeloid differentiation primary response protein MyD88. (296 aa)
LOC102285474Nuclear factor of activated T-cells, cytoplasmic 1-like. (454 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
KRASGTPase KRas. (189 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
RPS6KB2Ribosomal protein S6 kinase beta. (347 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
M91_10783Ig-like domain-containing protein. (129 aa)
EML4Echinoderm microtubule-associated protein-like 4. (992 aa)
ZAP70Non-specific protein-tyrosine kinase. (617 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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