STRINGSTRING
M91_03257 M91_03257 NPPC NPPC PDGFB PDGFB SRC SRC IKBKB IKBKB RELA RELA NQO1 NQO1 PLAT PLAT CTSV CTSV ASS1 ASS1 SDC2 SDC2 LOC102274807 LOC102274807 EDN1 EDN1 BCL2 BCL2 GSTM3 GSTM3 CALM3 CALM3 CDH5 CDH5 MMP9 MMP9 SDC1 SDC1 M91_10145 M91_10145 GSTO2 GSTO2 GSTO1 GSTO1 MGST1 MGST1 BMPR1B BMPR1B MAP2K5 MAP2K5 CALML4 CALML4 TNFRSF1A TNFRSF1A TXN TXN PIK3CB PIK3CB CALML5 CALML5 GSTA3 GSTA3 KDR KDR IL1R2 IL1R2 FOS FOS IL1R1 IL1R1 IL1A IL1A IL1B IL1B ACVR2A ACVR2A SUMO2 SUMO2 PECAM1 PECAM1 PRKAA2 PRKAA2 PIK3R1 PIK3R1 MMP2 MMP2 HSP90B1 HSP90B1 NOX1 NOX1 MGST2 MGST2 NCF1 NCF1 IFNG IFNG HSP90AB1 HSP90AB1 PDGFA PDGFA MAPK9 MAPK9 VEGFA VEGFA CAV3 CAV3 MAP3K5 MAP3K5 CALM1 CALM1 MAP2K4 MAP2K4 PTK2 PTK2 MAPK13 MAPK13 MAPK14 MAPK14 CYBA CYBA M91_15258 M91_15258 CCL2 CCL2 TNF TNF KEAP1 KEAP1 CAV2 CAV2 CAV1 CAV1 ARHGEF2 ARHGEF2 HMOX1 HMOX1 RHOA RHOA BMP4 BMP4 SQSTM1 SQSTM1 MAPK7 MAPK7 LOC102279723 LOC102279723 MAPK12 MAPK12 MAPK11 MAPK11 AKT2 AKT2 MGST3 MGST3 MEF2A MEF2A LOC102287375 LOC102287375 PIK3CA PIK3CA MAP3K7 MAP3K7 CTNNB1 CTNNB1 ACVR2B ACVR2B CHUK CHUK SUMO1 SUMO1 BMPR2 BMPR2 CTSL CTSL PIAS4 PIAS4 PIK3R3 PIK3R3 ENSBMUP00000025018 ENSBMUP00000025018 NFKB1 NFKB1 ITGA2B ITGA2B MAPK8 MAPK8 LOC102278214 LOC102278214 SELE SELE ACTB ACTB SDC4 SDC4 NCF2 NCF2 TP53 TP53 GSTA4 GSTA4 LOC102271929 LOC102271929 MAPK10 MAPK10 TRPV4 TRPV4 LOC102276661 LOC102276661 GSTT4 GSTT4 ITGAV ITGAV LOC102271748 LOC102271748 MAP2K6 MAP2K6 ACVR1 ACVR1 LOC102280361 LOC102280361 PRKCZ PRKCZ NFE2L2 NFE2L2 RAC2 RAC2 TXN2 TXN2 ITGB3 ITGB3 LOC102287938 LOC102287938 PIK3R2 PIK3R2 MAP2K7 MAP2K7 PRKAA1 PRKAA1 AKT1 AKT1 ACTG1 ACTG1 BMPR1A BMPR1A IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M91_03257Small ubiquitin-related modifier. (105 aa)
NPPCC-type natriuretic peptide. (126 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
SRCTyrosine-protein kinase. (559 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
RELATranscription factor p65. (549 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1. (274 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (567 aa)
CTSVCathepsin L1; Belongs to the peptidase C1 family. (334 aa)
ASS1Argininosuccinate synthase. (418 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (467 aa)
LOC102274807Glutathione S-transferase A1. (172 aa)
EDN1Endothelin-1. (202 aa)
BCL2Apoptosis regulator Bcl-2. (225 aa)
GSTM3Glutathione S-transferase. (225 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
MMP9Matrix metalloproteinase-9. (712 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (283 aa)
M91_10145Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
GSTO2Glutathione S-transferase omega-2; Belongs to the GST superfamily. (244 aa)
GSTO1Glutathione S-transferase omega-1. (344 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CALML4Calmodulin-like protein 4. (197 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (429 aa)
TXNThioredoxin. (105 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALML5Calmodulin. (148 aa)
GSTA3Glutathione S-transferase. (222 aa)
KDRKinase insert domain protein receptor. (1353 aa)
IL1R2Interleukin-1 receptor type 2. (400 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SUMO2Small ubiquitin-related modifier. (88 aa)
PECAM1Platelet endothelial cell adhesion molecule. (868 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
MMP272 kDa type IV collagenase. (661 aa)
HSP90B1Endoplasmin. (809 aa)
NOX1NADPH oxidase 1. (561 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
NCF1Neutrophil cytosol factor 1. (392 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
HSP90AB1Heat shock protein HSP 90-beta. (722 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (222 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
VEGFAVascular endothelial growth factor A. (197 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
PTK2Focal adhesion kinase 1. (1065 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
M91_15258Intercellular adhesion molecule 1. (321 aa)
CCL2C-C motif chemokine. (99 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (1275 aa)
HMOX1Heme oxygenase 1. (289 aa)
RHOATransforming protein RhoA. (193 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SQSTM1Sequestosome-1. (356 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (782 aa)
LOC102279723Heat shock protein 90 alpha family class A member 1. (119 aa)
MAPK12Mitogen-activated protein kinase. (374 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
MEF2AMyocyte-specific enhancer factor 2A. (498 aa)
LOC102287375Calmodulin. (149 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CTNNB1Catenin beta-1. (781 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (479 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
SUMO1Small ubiquitin-related modifier. (147 aa)
BMPR2Bone morphogenetic protein receptor type 2. (1038 aa)
CTSLCathepsin L1; Belongs to the peptidase C1 family. (330 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (513 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ENSBMUP00000025018Intercellular adhesion molecule 1-like. (132 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
ITGA2BIntegrin subunit alpha 2b. (1033 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
LOC102278214Intercellular adhesion molecule 1-like. (545 aa)
SELEE-selectin. (485 aa)
ACTBActin, cytoplasmic 1. (375 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (118 aa)
NCF2Neutrophil cytosol factor 2. (527 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
GSTA4Glutathione S-transferase A4. (251 aa)
LOC102271929Glutathione S-transferase P. (239 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
TRPV4Transient receptor putative cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
LOC102276661Glutathione S-transferase theta-1; Belongs to the GST superfamily. (598 aa)
GSTT4Glutathione S-transferase theta-4. (247 aa)
ITGAVIntegrin subunit alpha V. (986 aa)
LOC102271748Vascular cell adhesion protein 1. (740 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
LOC102280361Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
PRKCZProtein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (592 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2; Belongs to the bZIP family. (590 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
TXN2Thioredoxin, mitochondrial. (166 aa)
ITGB3Integrin beta. (788 aa)
LOC102287938Glutathione S-transferase A2. (309 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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