(65 nodes) Oxidoreductase complex network (Loa loa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOAG_13880	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
	LOAG_08023	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (256 aa)
	LOAG_09948	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (272 aa)
	LOAG_04402	Uncharacterized protein. (70 aa)
	A0A1I7VKM9	Uncharacterized protein. (54 aa)
	A0A1I7VLE9	Uncharacterized protein. (169 aa)
	LOAG_00519	NADH-ubiquinone oxidoreductase B12 subunit. (126 aa)
	LOAG_05118	Deoxynucleoside kinase. (441 aa)
	A0A1I7VMI4	Transket_pyr domain-containing protein. (324 aa)
	LOAG_04183	Cytochrome C1 family protein. (290 aa)
	A0A1I7VP12	Uncharacterized protein. (407 aa)
	A0A1I7VQ97	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (494 aa)
	A0A1I7VQW2	NADH dehydrogenase; Belongs to the complex I 75 kDa subunit family. (736 aa)
	A0A1I7VR18	PX domain-containing protein; Belongs to the complex I 49 kDa subunit family. (754 aa)
	A0A1I7VRA4	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (977 aa)
	A0A1I7VS89	Uncharacterized protein. (1172 aa)
	LOAG_03457	NADH-ubiquinone oxidoreductase 23 kDa subunit. (206 aa)
	LOAG_06412	NADH-ubiquinone oxidoreductase subunit B. (139 aa)
	A0A1I7VVI8	Uncharacterized protein. (366 aa)
	LOAG_00234	Uncharacterized protein. (179 aa)
	LOAG_07393	Uncharacterized protein. (152 aa)
	A0A1I7VWZ5	Uncharacterized protein. (176 aa)
	LOAG_15062	NADH-ubiquinone oxidoreductase B8 subunit. (99 aa)
	A0A1I7VXR0	Lipoyl-binding domain-containing protein. (767 aa)
	A0A1I7VY49	NADH-ubiquinone oxidoreductase Fe-S protein 7; Belongs to the complex I 20 kDa subunit family. (218 aa)
	LOAG_17464	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (728 aa)
	A0A1I7W0R1	Uncharacterized protein. (488 aa)
	A0A1I7W158	Uncharacterized protein. (243 aa)
	A0A1I7W170	Complex1_49kDa domain-containing protein. (242 aa)
	LOAG_01333	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (356 aa)
	A0A1I7W2H1	Uncharacterized protein. (222 aa)
	LOAG_10902	Uncharacterized protein. (173 aa)
	LOAG_17980	Complex1_30kDa domain-containing protein; Belongs to the complex I 30 kDa subunit family. (266 aa)
	LOAG_10884	Lipoyl-binding domain-containing protein. (172 aa)
	LOAG_10883	Dihydrolipoamide S-acetyltransferase. (367 aa)
	LOAG_16098	2-oxoacid_dh domain-containing protein. (78 aa)
	LOAG_10874	NADH Ubiquinone oxidoreductase Fe-S protein family member. (171 aa)
	LOAG_04117	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (151 aa)
	A0A1I7W5F8	Uncharacterized protein. (96 aa)
	LOAG_06318	Uncharacterized protein; Belongs to the complex I LYR family. (164 aa)
	A0A1I7V5Y3	Uncharacterized protein. (188 aa)
	A0A1I7V636	Uncharacterized protein. (65 aa)
	LOAG_02337	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (441 aa)
	LOAG_04830	Uncharacterized protein. (153 aa)
	LOAG_01846	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (364 aa)
	A0A1I7V840	Uncharacterized protein. (304 aa)
	A0A1I7V8X3	Uncharacterized protein. (241 aa)
	A0A1I7V904	Uncharacterized protein. (136 aa)
	LOAG_18211	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (355 aa)
	LOAG_00891	NADH-ubiquinone oxidoreductase 19 kDa subunit. (182 aa)
	A0A1I7V927	Uncharacterized protein. (1366 aa)
	A0A1I7V942	Uncharacterized protein. (129 aa)
	A0A1I7V974	Uncharacterized protein. (238 aa)
	LOAG_02826	Uncharacterized protein. (187 aa)
	LOAG_14748	NADH-ubiquinone oxidoreductase 17.3 kDa subunit. (155 aa)
	LOAG_18466	Dihydrolipoyl dehydrogenase. (495 aa)
	A0A1I7VCA0	2-oxoacid_dh domain-containing protein. (105 aa)
	LOAG_18724	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (646 aa)
	LOAG_18725	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (646 aa)
	LOAG_03576	NADH-ubiquinone oxidoreductase 18 kDa subunit. (178 aa)
	LOAG_10155	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (279 aa)
	A0A1I7VED8	Transket_pyr domain-containing protein. (996 aa)
	LOAG_05848	NADH-ubiquinone oxidoreductase 24 kDa subunit. (236 aa)
	LOAG_00716	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (373 aa)
	LOAG_06305	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (136 aa)

Your Current Organism:

Loa loa

NCBI taxonomy Id: 7209
Other names: L. loa, eye worm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I7V5Y3	A0A1I7V840	A0A1I7V5Y3	A0A1I7V840	Uncharacterized protein.	Uncharacterized protein.	0.996
A0A1I7V5Y3	A0A1I7V942	A0A1I7V5Y3	A0A1I7V942	Uncharacterized protein.	Uncharacterized protein.	0.416
A0A1I7V5Y3	A0A1I7V974	A0A1I7V5Y3	A0A1I7V974	Uncharacterized protein.	Uncharacterized protein.	0.416
A0A1I7V5Y3	A0A1I7VLE9	A0A1I7V5Y3	A0A1I7VLE9	Uncharacterized protein.	Uncharacterized protein.	0.950
A0A1I7V5Y3	A0A1I7VP12	A0A1I7V5Y3	A0A1I7VP12	Uncharacterized protein.	Uncharacterized protein.	0.434
A0A1I7V5Y3	A0A1I7VQ97	A0A1I7V5Y3	A0A1I7VQ97	Uncharacterized protein.	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.	0.985
A0A1I7V5Y3	A0A1I7VQW2	A0A1I7V5Y3	A0A1I7VQW2	Uncharacterized protein.	NADH dehydrogenase; Belongs to the complex I 75 kDa subunit family.	0.977
A0A1I7V5Y3	A0A1I7VR18	A0A1I7V5Y3	A0A1I7VR18	Uncharacterized protein.	PX domain-containing protein; Belongs to the complex I 49 kDa subunit family.	0.907
A0A1I7V5Y3	A0A1I7VS89	A0A1I7V5Y3	A0A1I7VS89	Uncharacterized protein.	Uncharacterized protein.	0.993
A0A1I7V5Y3	A0A1I7VVI8	A0A1I7V5Y3	A0A1I7VVI8	Uncharacterized protein.	Uncharacterized protein.	0.994
A0A1I7V5Y3	A0A1I7VWZ5	A0A1I7V5Y3	A0A1I7VWZ5	Uncharacterized protein.	Uncharacterized protein.	0.997
A0A1I7V5Y3	A0A1I7VY49	A0A1I7V5Y3	A0A1I7VY49	Uncharacterized protein.	NADH-ubiquinone oxidoreductase Fe-S protein 7; Belongs to the complex I 20 kDa subunit family.	0.983
A0A1I7V5Y3	A0A1I7W0R1	A0A1I7V5Y3	A0A1I7W0R1	Uncharacterized protein.	Uncharacterized protein.	0.996
A0A1I7V5Y3	A0A1I7W158	A0A1I7V5Y3	A0A1I7W158	Uncharacterized protein.	Uncharacterized protein.	0.907
A0A1I7V5Y3	A0A1I7W170	A0A1I7V5Y3	A0A1I7W170	Uncharacterized protein.	Complex1_49kDa domain-containing protein.	0.907
A0A1I7V5Y3	A0A1I7W2H1	A0A1I7V5Y3	A0A1I7W2H1	Uncharacterized protein.	Uncharacterized protein.	0.987
A0A1I7V5Y3	A0A1I7W5F8	A0A1I7V5Y3	A0A1I7W5F8	Uncharacterized protein.	Uncharacterized protein.	0.953
A0A1I7V5Y3	LOAG_00234	A0A1I7V5Y3	A0A1I7VW15	Uncharacterized protein.	Uncharacterized protein.	0.997
A0A1I7V5Y3	LOAG_00519	A0A1I7V5Y3	A0A1I7VLI4	Uncharacterized protein.	NADH-ubiquinone oxidoreductase B12 subunit.	0.950
A0A1I7V5Y3	LOAG_00891	A0A1I7V5Y3	A0A1I7V915	Uncharacterized protein.	NADH-ubiquinone oxidoreductase 19 kDa subunit.	0.997