(43 nodes) GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 network (Loa loa)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	LOAG_17371	Ubiquitin-60S ribosomal protein L40. (128 aa)
	LOAG_01378	26S proteasome non-ATPase regulatory subunit 7. (361 aa)
	LOAG_02338	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (174 aa)
	LOAG_03181	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
	A0A1I7V9M2	VWFA domain-containing protein. (383 aa)
	LOAG_01073	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (248 aa)
	A0A1I7V9W1	Uncharacterized protein. (229 aa)
	LOAG_18889	PCI domain-containing protein. (389 aa)
	LOAG_05097	PCI domain-containing protein. (494 aa)
	A0A1I7VC84	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (502 aa)
	LOAG_09447	Proteasome subunit beta; Belongs to the peptidase T1B family. (238 aa)
	LOAG_04838	Proteasome A-type and B-type family protein. (277 aa)
	LOAG_09639	CMGC/GSK protein kinase; Belongs to the protein kinase superfamily. (402 aa)
	LOAG_03239	E3 ubiquitin-protein ligase RBX1. (117 aa)
	LOAG_08245	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (235 aa)
	A0A1I7VHI9	Uncharacterized protein. (67 aa)
	LOAG_02141	PCI domain-containing protein. (293 aa)
	LOAG_02683	Proteasome Regulatory Particle. (409 aa)
	LOAG_01409	Proteasome subunit beta. (205 aa)
	LOAG_03677	26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (435 aa)
	LOAG_00942	CULLIN_2 domain-containing protein; Belongs to the cullin family. (805 aa)
	LOAG_17012	BESS domain-containing protein family protein. (762 aa)
	A0A1I7VNP3	Polyubiquitin, variant 1. (414 aa)
	LOAG_02608	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (934 aa)
	LOAG_05524	Proteasome A-type and B-type family protein. (273 aa)
	LOAG_09359	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (259 aa)
	A0A1I7VQA6	Proteasome subunit beta. (326 aa)
	LOAG_02032	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (529 aa)
	LOAG_01659	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (397 aa)
	A0A1I7VSB0	Proteasome subunit beta. (202 aa)
	A0A1I7VTG0	CSN8_PSD8_EIF3K domain-containing protein. (256 aa)
	LOAG_06303	26S proteasome non-ATPase regulatory subunit 14. (314 aa)
	A0A1I7VTR7	Uncharacterized protein. (196 aa)
	LOAG_04017	Ubiquitin. (162 aa)
	LOAG_05880	RPN-3 protein. (520 aa)
	LOAG_02565	Proteasome subunit beta. (232 aa)
	LOAG_03082	CMGC/GSK protein kinase; Belongs to the protein kinase superfamily. (368 aa)
	LOAG_18101	Uncharacterized protein. (493 aa)
	LOAG_17962	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1095 aa)
	LOAG_03437	Proteasome activator pa28 beta subunit family protein. (263 aa)
	LOAG_18444	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (250 aa)
	A0A1I7W310	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (1324 aa)
	LOAG_11027	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (440 aa)

Your Current Organism:

Loa loa

NCBI taxonomy Id: 7209
Other names: L. loa, eye worm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I7V9M2	A0A1I7V9W1	A0A1I7V9M2	A0A1I7V9W1	VWFA domain-containing protein.	Uncharacterized protein.	0.895
A0A1I7V9M2	A0A1I7VC84	A0A1I7V9M2	A0A1I7VC84	VWFA domain-containing protein.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.999
A0A1I7V9M2	A0A1I7VHI9	A0A1I7V9M2	A0A1I7VHI9	VWFA domain-containing protein.	Uncharacterized protein.	0.966
A0A1I7V9M2	A0A1I7VNP3	A0A1I7V9M2	A0A1I7VNP3	VWFA domain-containing protein.	Polyubiquitin, variant 1.	0.984
A0A1I7V9M2	A0A1I7VQA6	A0A1I7V9M2	A0A1I7VQA6	VWFA domain-containing protein.	Proteasome subunit beta.	0.992
A0A1I7V9M2	A0A1I7VSB0	A0A1I7V9M2	A0A1I7VSB0	VWFA domain-containing protein.	Proteasome subunit beta.	0.993
A0A1I7V9M2	A0A1I7VTG0	A0A1I7V9M2	A0A1I7VTG0	VWFA domain-containing protein.	CSN8_PSD8_EIF3K domain-containing protein.	0.984
A0A1I7V9M2	A0A1I7VTR7	A0A1I7V9M2	A0A1I7VTR7	VWFA domain-containing protein.	Uncharacterized protein.	0.997
A0A1I7V9M2	A0A1I7W310	A0A1I7V9M2	A0A1I7W310	VWFA domain-containing protein.	Proteasome endopeptidase complex; Belongs to the peptidase T1A family.	0.994
A0A1I7V9M2	LOAG_00942	A0A1I7V9M2	A0A1I7VM06	VWFA domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.708
A0A1I7V9M2	LOAG_01073	A0A1I7V9M2	A0A1I7V9M7	VWFA domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.996
A0A1I7V9M2	LOAG_01378	A0A1I7V9M2	A0A1I7VMD9	VWFA domain-containing protein.	26S proteasome non-ATPase regulatory subunit 7.	0.998
A0A1I7V9M2	LOAG_01409	A0A1I7V9M2	A0A1I7VKX1	VWFA domain-containing protein.	Proteasome subunit beta.	0.997
A0A1I7V9M2	LOAG_01659	A0A1I7V9M2	A0A1I7VRX2	VWFA domain-containing protein.	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.997
A0A1I7V9M2	LOAG_02032	A0A1I7V9M2	A0A1I7VQL7	VWFA domain-containing protein.	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family.	0.998
A0A1I7V9M2	LOAG_02141	A0A1I7V9M2	A0A1I7VJX9	VWFA domain-containing protein.	PCI domain-containing protein.	0.984
A0A1I7V9M2	LOAG_02338	A0A1I7V9M2	A0A1I7V6J0	VWFA domain-containing protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.652
A0A1I7V9M2	LOAG_02565	A0A1I7V9M2	A0A1I7VX93	VWFA domain-containing protein.	Proteasome subunit beta.	0.997
A0A1I7V9M2	LOAG_02608	A0A1I7V9M2	A0A1I7VNV8	VWFA domain-containing protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.997
A0A1I7V9M2	LOAG_02683	A0A1I7V9M2	A0A1I7VKC8	VWFA domain-containing protein.	Proteasome Regulatory Particle.	0.999