(47 nodes) Metabolism of nucleotides, and Adenosine/AMP deaminase N-terminal network (Drosophila ananassae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	DanaGF16878	Uncharacterized protein. (500 aa)
	DanaGF19072	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (806 aa)
	DanaGF28103	Uncharacterized protein. (444 aa)
	DanaGF24649	Uncharacterized protein, isoform D. (404 aa)
	DanaGF13769	Uncharacterized protein, isoform G. (824 aa)
	DanaGF16309	Uncharacterized protein, isoform B. (669 aa)
	DanaGF18034	Uncharacterized protein. (807 aa)
	DanaGF16421	Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (288 aa)
	DanaGF18138	UDG domain-containing protein. (288 aa)
	DanaGF16876	Uncharacterized protein. (506 aa)
	DanaGF16866	Uncharacterized protein. (422 aa)
	DanaGF16846	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (546 aa)
	DanaGF17915	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
	DanaGF18503	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (183 aa)
	GF17012	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (448 aa)
	DanaGF18559	Uncharacterized protein, isoform A. (368 aa)
	DanaGF23996	Uncharacterized protein, isoform A. (260 aa)
	DanaGF25318	CMP/dCMP-type deaminase domain-containing protein. (196 aa)
	DanaGF23892	Uncharacterized protein, isoform A. (557 aa)
	DanaGF10059	Uncharacterized protein. (260 aa)
	DanaGF10608	Guanylate kinase-like domain-containing protein. (235 aa)
	DanaGF24862	Uncharacterized protein, isoform C. (392 aa)
	DanaGF24950	Pribosyltran domain-containing protein. (181 aa)
	DanaGF24236	Enkurin domain-containing protein. (308 aa)
	DanaGF10885	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (544 aa)
	DanaGF25174	Uncharacterized protein, isoform A. (350 aa)
	DanaGF11973	CMP/dCMP-type deaminase domain-containing protein. (361 aa)
	DanaGF11383	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (320 aa)
	DanaGF11317	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (383 aa)
	DanaGF11825	PNP_UDP_1 domain-containing protein. (337 aa)
	DanaGF13118	Uridine kinase; Belongs to the uridine kinase family. (618 aa)
	DanaGF13125	Uncharacterized protein, isoform A; Belongs to the 5'-nucleotidase family. (600 aa)
	DanaGF13126	Uncharacterized protein, isoform B; Belongs to the 5'-nucleotidase family. (596 aa)
	DanaGF13127	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (598 aa)
	DanaGF13128	Uncharacterized protein, isoform A; Belongs to the 5'-nucleotidase family. (588 aa)
	DanaGF13205	Thymidylate_kin domain-containing protein. (211 aa)
	DanaGF12238	PfkB domain-containing protein. (365 aa)
	DanaGF15410	Glutamine amidotransferase type-1 domain-containing protein. (1353 aa)
	DanaGF14907	Thymidylat_synt domain-containing protein. (340 aa)
	DanaGF15152	Uncharacterized protein. (700 aa)
	DanaGF15633	dUTPase domain-containing protein. (183 aa)
	DanaGF14164	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa)
	DanaGF15273	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (158 aa)
	DanaGF15274	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa)
	DanaGF15275	Uncharacterized protein, isoform A. (264 aa)
	DanaGF21436	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (540 aa)
	DanaGF22351	IU_nuc_hydro domain-containing protein. (460 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10059	DanaGF11825	B3M512	B3MFJ5	Uncharacterized protein.	PNP_UDP_1 domain-containing protein.	0.578
DanaGF10059	DanaGF13125	B3M512	B3MG77	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the 5'-nucleotidase family.	0.439
DanaGF10059	DanaGF13126	B3M512	B3MG78	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the 5'-nucleotidase family.	0.439
DanaGF10059	DanaGF13127	B3M512	B3MG79	Uncharacterized protein.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.439
DanaGF10059	DanaGF13128	B3M512	B3MGL7	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the 5'-nucleotidase family.	0.439
DanaGF10059	DanaGF13769	B3M512	A0A0P8YEA9	Uncharacterized protein.	Uncharacterized protein, isoform G.	0.439
DanaGF10059	DanaGF16421	B3M512	B3LVB2	Uncharacterized protein.	Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.	0.554
DanaGF10059	DanaGF16876	B3M512	B3LWV6	Uncharacterized protein.	Uncharacterized protein.	0.434
DanaGF10059	DanaGF16878	B3M512	A0A0N8P1G8	Uncharacterized protein.	Uncharacterized protein.	0.434
DanaGF10059	DanaGF19072	B3M512	A0A0P8XJ75	Uncharacterized protein.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.434
DanaGF10059	DanaGF21436	B3M512	B3MSB7	Uncharacterized protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.789
DanaGF10059	DanaGF23892	B3M512	B3M4T9	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.434
DanaGF10059	DanaGF24862	B3M512	B3M6Q5	Uncharacterized protein.	Uncharacterized protein, isoform C.	0.578
DanaGF10059	DanaGF28103	B3M512	A0A0P8XZ69	Uncharacterized protein.	Uncharacterized protein.	0.434
DanaGF10608	DanaGF11383	B3M5K5	B3MDM8	Guanylate kinase-like domain-containing protein.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.900
DanaGF10608	DanaGF13125	B3M5K5	B3MG77	Guanylate kinase-like domain-containing protein.	Uncharacterized protein, isoform A; Belongs to the 5'-nucleotidase family.	0.901
DanaGF10608	DanaGF13128	B3M5K5	B3MGL7	Guanylate kinase-like domain-containing protein.	Uncharacterized protein, isoform A; Belongs to the 5'-nucleotidase family.	0.901
DanaGF10608	DanaGF13205	B3M5K5	B3MHV0	Guanylate kinase-like domain-containing protein.	Thymidylate_kin domain-containing protein.	0.417
DanaGF10608	DanaGF13769	B3M5K5	A0A0P8YEA9	Guanylate kinase-like domain-containing protein.	Uncharacterized protein, isoform G.	0.901
DanaGF10608	DanaGF14164	B3M5K5	B3MP77	Guanylate kinase-like domain-containing protein.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.951