(11 nodes) Vitamin B6 biosynthetic process, and PLP-binding barrel network (Drosophila ananassae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	DanaGF16863	Uncharacterized protein, isoform B. (246 aa)
	DanaGF16862	Uncharacterized protein. (260 aa)
	DanaGF18174	Putative_PNPOx domain-containing protein. (260 aa)
	DanaGF16195	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (254 aa)
	DanaGF10495	DUF4774 domain-containing protein. (607 aa)
	DanaGF10684	Phos_pyr_kin domain-containing protein. (329 aa)
	DanaGF10685	Uncharacterized protein. (161 aa)
	DanaGF14490	N-acetyltransferase domain-containing protein. (293 aa)
	DanaGF22444	Putative_PNPOx domain-containing protein. (222 aa)
	DanaGF15143	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (295 aa)
	GF19489	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family. (229 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10495	DanaGF14490	B3M449	B3MKK5	DUF4774 domain-containing protein.	N-acetyltransferase domain-containing protein.	0.802
DanaGF10495	DanaGF16862	B3M449	B3LXC5	DUF4774 domain-containing protein.	Uncharacterized protein.	0.537
DanaGF10495	DanaGF16863	B3M449	A0A0P8YEM6	DUF4774 domain-containing protein.	Uncharacterized protein, isoform B.	0.537
DanaGF10684	DanaGF16195	B3M6E0	B3LZC9	Phos_pyr_kin domain-containing protein.	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	0.721
DanaGF10684	DanaGF16862	B3M6E0	B3LXC5	Phos_pyr_kin domain-containing protein.	Uncharacterized protein.	0.821
DanaGF10684	DanaGF16863	B3M6E0	A0A0P8YEM6	Phos_pyr_kin domain-containing protein.	Uncharacterized protein, isoform B.	0.981
DanaGF10684	DanaGF18174	B3M6E0	B3LXF0	Phos_pyr_kin domain-containing protein.	Putative_PNPOx domain-containing protein.	0.631
DanaGF10684	DanaGF22444	B3M6E0	B3MWH7	Phos_pyr_kin domain-containing protein.	Putative_PNPOx domain-containing protein.	0.627
DanaGF10684	GF19489	B3M6E0	B3N0Q8	Phos_pyr_kin domain-containing protein.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.	0.460
DanaGF10685	DanaGF16195	B3M6E1	B3LZC9	Uncharacterized protein.	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	0.721
DanaGF10685	DanaGF16862	B3M6E1	B3LXC5	Uncharacterized protein.	Uncharacterized protein.	0.631
DanaGF10685	DanaGF16863	B3M6E1	A0A0P8YEM6	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.631
DanaGF10685	DanaGF18174	B3M6E1	B3LXF0	Uncharacterized protein.	Putative_PNPOx domain-containing protein.	0.631
DanaGF10685	DanaGF22444	B3M6E1	B3MWH7	Uncharacterized protein.	Putative_PNPOx domain-containing protein.	0.627
DanaGF10685	GF19489	B3M6E1	B3N0Q8	Uncharacterized protein.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.	0.460
DanaGF14490	DanaGF10495	B3MKK5	B3M449	N-acetyltransferase domain-containing protein.	DUF4774 domain-containing protein.	0.802
DanaGF14490	DanaGF16862	B3MKK5	B3LXC5	N-acetyltransferase domain-containing protein.	Uncharacterized protein.	0.587
DanaGF14490	DanaGF16863	B3MKK5	A0A0P8YEM6	N-acetyltransferase domain-containing protein.	Uncharacterized protein, isoform B.	0.587
DanaGF15143	GF19489	B3MX40	B3N0Q8	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.	0.946
DanaGF16195	DanaGF10684	B3LZC9	B3M6E0	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	Phos_pyr_kin domain-containing protein.	0.721