(41 nodes) Mixed, incl. Resolution of D-Loop Structures, and Fanconi anemia pathway network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF26759	Uncharacterized protein. (1589 aa)
	DanaGF13624	Uncharacterized protein. (1074 aa)
	DanaGF27564	Uncharacterized protein. (175 aa)
	DanaGF18603	Uncharacterized protein. (1555 aa)
	DanaGF17509	RECA_2 domain-containing protein. (345 aa)
	DanaGF16205	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (334 aa)
	slx1	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (299 aa)
	DanaGF16620	Uncharacterized protein. (1469 aa)
	DanaGF25191	Uncharacterized protein. (1091 aa)
	DanaGF10575	Uncharacterized protein, isoform A. (1163 aa)
	DanaGF10737	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1187 aa)
	DanaGF24946	BRCT domain-containing protein. (1340 aa)
	DanaGF23568	Uncharacterized protein. (654 aa)
	DanaGF25130	FHA domain-containing protein. (829 aa)
	DanaGF24618	Uncharacterized protein, isoform A. (850 aa)
	DanaGF11584	Uncharacterized protein, isoform C. (173 aa)
	DanaGF12823	Uncharacterized protein. (236 aa)
	DanaGF12969	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2515 aa)
	DanaGF11892	Zinc-hook domain-containing protein. (1308 aa)
	DanaGF11871	Uncharacterized protein. (919 aa)
	DanaGF11801	Uncharacterized protein. (1024 aa)
	DanaGF13669	DNA_mis_repair domain-containing protein. (663 aa)
	DanaGF13728	Rad51 domain-containing protein. (348 aa)
	DanaGF13776	ERCC4 domain-containing protein. (305 aa)
	DanaGF14885	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (917 aa)
	DanaGF15526	Uncharacterized protein. (1269 aa)
	DanaGF14831	Uncharacterized protein. (714 aa)
	okr	DNA repair and recombination protein RAD54-like; Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54 (By similarity). (791 aa)
	DanaGF14771	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (606 aa)
	DanaGF14242	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1239 aa)
	DanaGF20299	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (878 aa)
	GF20802	Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. (994 aa)
	DanaGF21474	ERCC4 domain-containing protein. (973 aa)
	DanaGF21494	XPA_C domain-containing protein. (292 aa)
	DanaGF23244	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
	DanaGF23286	RECA_2 domain-containing protein. (204 aa)
	DanaGF24241	RPA_C domain-containing protein. (245 aa)
	DanaGF22599	Uncharacterized protein. (1460 aa)
	DanaGF11791	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2763 aa)
	DanaGF19441	Uncharacterized protein. (113 aa)
	DanaGF22118	ERCC4 domain-containing protein. (431 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10575	DanaGF11584	B3M566	B3MBJ4	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C.	0.423
DanaGF10575	DanaGF11791	B3M566	B3MX95	Uncharacterized protein, isoform A.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.616
DanaGF10575	DanaGF11801	B3M566	B3MG38	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.455
DanaGF10575	DanaGF11892	B3M566	B3MEF0	Uncharacterized protein, isoform A.	Zinc-hook domain-containing protein.	0.418
DanaGF10575	DanaGF12823	B3M566	B3MC73	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.974
DanaGF10575	DanaGF13624	B3M566	A0A0P8YDL6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.552
DanaGF10575	DanaGF13728	B3M566	B3MHI2	Uncharacterized protein, isoform A.	Rad51 domain-containing protein.	0.444
DanaGF10575	DanaGF13776	B3M566	B3MIK5	Uncharacterized protein, isoform A.	ERCC4 domain-containing protein.	0.944
DanaGF10575	DanaGF14242	B3M566	B3MN55	Uncharacterized protein, isoform A.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.712
DanaGF10575	DanaGF14771	B3M566	B3MMU9	Uncharacterized protein, isoform A.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.458
DanaGF10575	DanaGF14831	B3M566	B3MM41	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.765
DanaGF10575	DanaGF14885	B3M566	B3MLN4	Uncharacterized protein, isoform A.	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.432
DanaGF10575	DanaGF15526	B3M566	B3MLW2	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.488
DanaGF10575	DanaGF16205	B3M566	B3LZB4	Uncharacterized protein, isoform A.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.672
DanaGF10575	DanaGF16620	B3M566	B3M115	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.830
DanaGF10575	DanaGF17509	B3M566	B3LVF6	Uncharacterized protein, isoform A.	RECA_2 domain-containing protein.	0.618
DanaGF10575	DanaGF18603	B3M566	B3LVD0	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.734
DanaGF10575	DanaGF20299	B3M566	B3MQ67	Uncharacterized protein, isoform A.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.725
DanaGF10575	DanaGF21474	B3M566	B3MSI5	Uncharacterized protein, isoform A.	ERCC4 domain-containing protein.	0.987
DanaGF10575	DanaGF22118	B3M566	B3MYD5	Uncharacterized protein, isoform A.	ERCC4 domain-containing protein.	0.979