(37 nodes) Mixed, incl. IGF1R signaling cascade, and Interleukin-3, Interleukin-5 and GM-CSF signaling network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF11039	Uncharacterized protein, isoform C. (1638 aa)
	DanaGF22925	Uncharacterized protein, isoform B. (938 aa)
	DanaGF15271	Receptor protein-tyrosine kinase. (1183 aa)
	DanaGF17811	Uncharacterized protein, isoform B. (2121 aa)
	DanaGF27276	Uncharacterized protein. (1054 aa)
	DanaGF24460	PDGF_2 domain-containing protein. (637 aa)
	DanaGF15994	Uncharacterized protein, isoform B. (1039 aa)
	DanaGF20837	Uncharacterized protein, isoform J. (1614 aa)
	DanaGF17516	Uncharacterized protein, isoform A. (1233 aa)
	DanaGF17357	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (722 aa)
	DanaGF16791	G_PROTEIN_RECEP_F3_4 domain-containing protein. (892 aa)
	DanaGF18247	Fibroblast growth factor receptor. (734 aa)
	DanaGF18824	SH2 domain-containing protein. (207 aa)
	DanaGF18327	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1099 aa)
	DanaGF16108	Uncharacterized protein. (514 aa)
	DanaGF24399	Uncharacterized protein. (856 aa)
	DanaGF24235	Uncharacterized protein, isoform A. (862 aa)
	DanaGF10268	Uncharacterized protein. (591 aa)
	DanaGF24725	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1184 aa)
	DanaGF24647	Uncharacterized protein. (411 aa)
	DanaGF11457	Uncharacterized protein. (733 aa)
	DanaGF11456	Uncharacterized protein. (771 aa)
	DanaGF11180	Uncharacterized protein. (211 aa)
	DanaGF14259	Uncharacterized protein. (1587 aa)
	DanaGF14174	Uncharacterized protein, isoform C; Belongs to the protein kinase superfamily. Tyr protein kinase family. (803 aa)
	DanaGF14676	Uncharacterized protein, isoform D. (452 aa)
	DanaGF15268	Tyrosine-protein kinase. (786 aa)
	DanaGF15270	Receptor protein-tyrosine kinase. (1578 aa)
	chico	Insulin receptor substrate 1; Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signal [...] (940 aa)
	DanaGF20397	Uncharacterized protein. (2561 aa)
	DanaGF21174	Uncharacterized protein. (619 aa)
	DanaGF21460	Uncharacterized protein. (803 aa)
	DanaGF24471	PDGF_2 domain-containing protein. (371 aa)
	DanaGF20638	Uncharacterized protein, isoform A. (504 aa)
	DanaGF23415	Uncharacterized protein. (278 aa)
	DanaGF19053	Uncharacterized protein, isoform B; Belongs to the PDGF/VEGF growth factor family. (328 aa)
	DanaGF25100	Uncharacterized protein. (442 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10268	DanaGF11180	B3M831	B3MGZ3	Uncharacterized protein.	Uncharacterized protein.	0.813
DanaGF10268	DanaGF21460	B3M831	B3MSF7	Uncharacterized protein.	Uncharacterized protein.	0.428
DanaGF10268	DanaGF22925	B3M831	A0A0P8XDU9	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.648
DanaGF10268	DanaGF24399	B3M831	B3M5I4	Uncharacterized protein.	Uncharacterized protein.	0.984
DanaGF10268	DanaGF25100	B3M831	B3N297	Uncharacterized protein.	Uncharacterized protein.	0.984
DanaGF11039	DanaGF11180	A0A0N8P0J6	B3MGZ3	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.718
DanaGF11039	DanaGF14259	A0A0N8P0J6	B3MN28	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.760
DanaGF11039	DanaGF14676	A0A0N8P0J6	B3MP16	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform D.	0.403
DanaGF11039	DanaGF15268	A0A0N8P0J6	B3MPH0	Uncharacterized protein, isoform C.	Tyrosine-protein kinase.	0.523
DanaGF11039	DanaGF15270	A0A0N8P0J6	B3MPH3	Uncharacterized protein, isoform C.	Receptor protein-tyrosine kinase.	0.440
DanaGF11039	DanaGF15271	A0A0N8P0J6	A0A0P8XFF2	Uncharacterized protein, isoform C.	Receptor protein-tyrosine kinase.	0.485
DanaGF11039	DanaGF15994	A0A0N8P0J6	A0A0P9BLS6	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform B.	0.650
DanaGF11039	DanaGF18247	A0A0N8P0J6	B3LYP9	Uncharacterized protein, isoform C.	Fibroblast growth factor receptor.	0.414
DanaGF11039	DanaGF18327	A0A0N8P0J6	B3M0A8	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family.	0.630
DanaGF11039	DanaGF18824	A0A0N8P0J6	B3LZC4	Uncharacterized protein, isoform C.	SH2 domain-containing protein.	0.479
DanaGF11039	DanaGF20397	A0A0N8P0J6	B3MQ86	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.428
DanaGF11039	DanaGF20638	A0A0N8P0J6	B3MUJ4	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform A.	0.625
DanaGF11039	DanaGF20837	A0A0N8P0J6	A0A0P9BUM9	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform J.	0.465
DanaGF11039	DanaGF21174	A0A0N8P0J6	B3MQX3	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.975
DanaGF11039	DanaGF21460	A0A0N8P0J6	B3MSF7	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.588