(45 nodes) RAB geranylgeranylation, and HOPS complex network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF27970	Uncharacterized protein, isoform A. (1128 aa)
	DanaGF27158	Uncharacterized protein. (211 aa)
	DanaGF26548	Uncharacterized protein. (200 aa)
	DanaGF17026	Uncharacterized protein, isoform D. (272 aa)
	DanaGF16935	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (640 aa)
	DanaGF16325	Vps16_C domain-containing protein. (446 aa)
	DanaGF18770	Uncharacterized protein, isoform A. (213 aa)
	DanaGF17263	Uncharacterized protein. (205 aa)
	DanaGF18924	Uncharacterized protein. (508 aa)
	DanaGF16588	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (834 aa)
	DanaGF17118	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
	DanaGF18478	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (574 aa)
	DanaGF17031	CG5915-PA. (207 aa)
	DanaGF24448	Uncharacterized protein. (699 aa)
	DanaGF10255	Uncharacterized protein. (480 aa)
	DanaGF10277	Uncharacterized protein, isoform A. (450 aa)
	DanaGF10843	Uncharacterized protein. (207 aa)
	DanaGF10899	RING-type domain-containing protein. (1229 aa)
	DanaGF10394	Uncharacterized protein. (212 aa)
	DanaGF11534	Rab-GAP TBC domain-containing protein. (983 aa)
	DanaGF12981	Uncharacterized protein. (646 aa)
	DanaGF11842	Uncharacterized protein, isoform A. (261 aa)
	DanaGF11718	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (517 aa)
	DanaGF14043	Uncharacterized protein. (253 aa)
	DanaGF14037	Uncharacterized protein. (922 aa)
	DanaGF14990	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (341 aa)
	DanaGF15504	Uncharacterized protein, isoform A. (504 aa)
	DanaGF14883	Uncharacterized protein, isoform A. (239 aa)
	DanaGF15280	Uncharacterized protein, isoform A. (219 aa)
	DanaGF20198	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (643 aa)
	DanaGF21221	UDENN domain-containing protein. (2115 aa)
	DanaGF21025	Uncharacterized protein. (218 aa)
	DanaGF20909	Uncharacterized protein. (198 aa)
	DanaGF19992	RING-type domain-containing protein. (712 aa)
	DanaGF23148	CNH domain-containing protein. (873 aa)
	DanaGF20733	Rab-GAP TBC domain-containing protein. (712 aa)
	DanaGF21994	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa)
	DanaGF23465	Uncharacterized protein. (1341 aa)
	DanaGF23518	Uncharacterized protein. (528 aa)
	DanaGF22592	Uncharacterized protein, isoform A. (1730 aa)
	DanaGF22152	Uncharacterized protein. (225 aa)
	DanaGF22166	Pep3_Vps18 domain-containing protein. (1008 aa)
	DanaGF21965	Uncharacterized protein. (404 aa)
	DanaGF19205	AN1-type domain-containing protein. (242 aa)
	DanaGF22734	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (839 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10255	DanaGF10843	B3M7Z8	B3M8T8	Uncharacterized protein.	Uncharacterized protein.	0.575
DanaGF10255	DanaGF10899	B3M7Z8	B3M9Y3	Uncharacterized protein.	RING-type domain-containing protein.	0.577
DanaGF10255	DanaGF11842	B3M7Z8	B3MFG1	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.402
DanaGF10255	DanaGF14043	B3M7Z8	B3MK03	Uncharacterized protein.	Uncharacterized protein.	0.740
DanaGF10255	DanaGF14883	B3M7Z8	B3MLN6	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.406
DanaGF10255	DanaGF15280	B3M7Z8	B3MPJ2	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.749
DanaGF10255	DanaGF16588	B3M7Z8	B3M1L0	Uncharacterized protein.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.966
DanaGF10255	DanaGF16935	B3M7Z8	B3LW38	Uncharacterized protein.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.910
DanaGF10255	DanaGF17026	B3M7Z8	A0A0P9C895	Uncharacterized protein.	Uncharacterized protein, isoform D.	0.810
DanaGF10255	DanaGF17031	B3M7Z8	B3M307	Uncharacterized protein.	CG5915-PA.	0.810
DanaGF10255	DanaGF18478	B3M7Z8	B3M2G2	Uncharacterized protein.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.451
DanaGF10255	DanaGF18770	B3M7Z8	B3LYA3	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.575
DanaGF10255	DanaGF19992	B3M7Z8	B3MTK7	Uncharacterized protein.	RING-type domain-containing protein.	0.967
DanaGF10255	DanaGF20198	B3M7Z8	B3MQQ8	Uncharacterized protein.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.910
DanaGF10255	DanaGF21994	B3M7Z8	B3MUU8	Uncharacterized protein.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.847
DanaGF10255	DanaGF22166	B3M7Z8	B3MYL2	Uncharacterized protein.	Pep3_Vps18 domain-containing protein.	0.965
DanaGF10255	DanaGF22734	B3M7Z8	B3N026	Uncharacterized protein.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.967
DanaGF10255	DanaGF23148	B3M7Z8	B3MTQ2	Uncharacterized protein.	CNH domain-containing protein.	0.966
DanaGF10255	DanaGF23518	B3M7Z8	B3MVJ2	Uncharacterized protein.	Uncharacterized protein.	0.999
DanaGF10255	DanaGF24448	B3M7Z8	B3M530	Uncharacterized protein.	Uncharacterized protein.	0.612