42 items (Drosophila ananassae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF23794	WD_REPEATS_REGION domain-containing protein. (424 aa)
	DanaGF25100	Uncharacterized protein. (442 aa)
	DanaGF13888	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (763 aa)
	DanaGF19146	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1234 aa)
	DanaGF19053	Uncharacterized protein, isoform B; Belongs to the PDGF/VEGF growth factor family. (328 aa)
	DanaGF19359	Uncharacterized protein. (1899 aa)
	DanaGF22940	Uncharacterized protein, isoform A. (1266 aa)
	DanaGF22712	Uncharacterized protein, isoform A. (2037 aa)
	DanaGF20874	Protein kinase domain-containing protein. (1170 aa)
	DanaGF20304	Uncharacterized protein, isoform A. (174 aa)
	DanaGF20173	Uncharacterized protein. (183 aa)
	DanaGF14126	Mitogen-activated protein kinase. (376 aa)
	chico	Insulin receptor substrate 1; Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signal [...] (940 aa)
	DanaGF15270	Receptor protein-tyrosine kinase. (1578 aa)
	DanaGF14692	Uncharacterized protein. (441 aa)
	DanaGF14375	EGF-like domain-containing protein. (333 aa)
	DanaGF14975	Uncharacterized protein, isoform A. (951 aa)
	DanaGF15435	Uncharacterized protein. (421 aa)
	DanaGF15305	Uncharacterized protein. (747 aa)
	DanaGF11717	Non-specific serine/threonine protein kinase. (1185 aa)
	DanaGF11771	VIR_N domain-containing protein. (1842 aa)
	DanaGF12987	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (1508 aa)
	DanaGF12966	ORC_WH_C domain-containing protein. (722 aa)
	DanaGF13466	BZIP domain-containing protein. (450 aa)
	DanaGF12821	Receptor protein-tyrosine kinase. (1439 aa)
	DanaGF24725	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1184 aa)
	DanaGF10661	Uncharacterized protein, isoform A. (444 aa)
	DanaGF24399	Uncharacterized protein. (856 aa)
	DanaGF10067	Uncharacterized protein. (192 aa)
	DanaGF18514	Uncharacterized protein. (614 aa)
	DanaGF18327	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1099 aa)
	DanaGF16155	Uncharacterized protein. (602 aa)
	DanaGF16724	Uncharacterized protein. (491 aa)
	DanaGF16263	Uncharacterized protein, isoform D; Belongs to the DOCK family. (1990 aa)
	vn	Vein, isoform D. (609 aa)
	DanaGF17811	Uncharacterized protein, isoform B. (2121 aa)
	DanaGF11137	Uncharacterized protein, isoform B. (2396 aa)
	DanaGF23405	Uncharacterized protein. (287 aa)
	DanaGF24504	Uncharacterized protein, isoform C. (5588 aa)
	DanaGF15271	Receptor protein-tyrosine kinase. (1183 aa)
	DanaGF19553	Uncharacterized protein, isoform E. (1808 aa)
	DanaGF22979	Uncharacterized protein, isoform B. (838 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10067	DanaGF12821	B3M528	B3MC66	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.603
DanaGF10067	DanaGF12987	B3M528	B3MDW0	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.561
DanaGF10067	DanaGF14126	B3M528	B3MPN7	Uncharacterized protein.	Mitogen-activated protein kinase.	0.992
DanaGF10067	DanaGF16155	B3M528	B3LZY7	Uncharacterized protein.	Uncharacterized protein.	0.562
DanaGF10067	DanaGF16263	B3M528	A0A0P9A1P7	Uncharacterized protein.	Uncharacterized protein, isoform D; Belongs to the DOCK family.	0.906
DanaGF10067	DanaGF16724	B3M528	B3LZ87	Uncharacterized protein.	Uncharacterized protein.	0.605
DanaGF10067	DanaGF18327	B3M528	B3M0A8	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family.	0.503
DanaGF10067	DanaGF19146	B3M528	B3N0S7	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.538
DanaGF10067	DanaGF20304	B3M528	B3MQ57	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.617
DanaGF10067	DanaGF20874	B3M528	B3MS41	Uncharacterized protein.	Protein kinase domain-containing protein.	0.553
DanaGF10661	DanaGF14126	B3M632	B3MPN7	Uncharacterized protein, isoform A.	Mitogen-activated protein kinase.	0.596
DanaGF10661	DanaGF16724	B3M632	B3LZ87	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.686
DanaGF12821	DanaGF10067	B3MC66	B3M528	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.603
DanaGF12821	DanaGF12987	B3MC66	B3MDW0	Receptor protein-tyrosine kinase.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.879
DanaGF12821	DanaGF13888	B3MC66	B3N197	Receptor protein-tyrosine kinase.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.805
DanaGF12821	DanaGF14375	B3MC66	B3MLV9	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.918
DanaGF12821	DanaGF15270	B3MC66	B3MPH3	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.598
DanaGF12821	DanaGF15271	B3MC66	A0A0P8XFF2	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.598
DanaGF12821	DanaGF15305	B3MC66	B3MJC2	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.435
DanaGF12821	DanaGF16155	B3MC66	B3LZY7	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.528