(78 nodes) Cellular ketone metabolic process network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF20000	Uncharacterized protein; Belongs to the cytochrome P450 family. (481 aa)
	DanaGF19436	Uncharacterized protein. (628 aa)
	DanaGF19427	GMC_OxRdtase_N domain-containing protein. (623 aa)
	DanaGF19368	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
	DanaGF19422	Uncharacterized protein, isoform A. (626 aa)
	DanaGF19423	Uncharacterized protein. (615 aa)
	DanaGF19424	GMC_OxRdtase_N domain-containing protein. (633 aa)
	DanaGF27071	Rieske domain-containing protein. (395 aa)
	DanaGF19435	Uncharacterized protein. (630 aa)
	DanaGF21860	Uncharacterized protein. (288 aa)
	DanaGF20760	Uncharacterized protein. (1919 aa)
	DanaGF19426	GMC_OxRdtase_N domain-containing protein. (639 aa)
	DanaGF19434	Uncharacterized protein. (616 aa)
	DanaGF19433	Uncharacterized protein. (620 aa)
	DanaGF26612	Uncharacterized protein; Belongs to the cytochrome P450 family. (520 aa)
	DanaGF10361	Uncharacterized protein, isoform D. (343 aa)
	DanaGF27979	Uncharacterized protein. (248 aa)
	DanaGF11062	Uncharacterized protein, isoform B. (244 aa)
	DanaGF27023	GMC_OxRdtase_N domain-containing protein. (625 aa)
	DanaGF21986	Uncharacterized protein. (512 aa)
	DanaGF21979	Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
	DanaGF22196	Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
	DanaGF22197	Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa)
	DanaGF17432	Uncharacterized protein. (332 aa)
	DanaGF18718	Uncharacterized protein, isoform A. (1657 aa)
	DanaGF16762	Uncharacterized protein. (616 aa)
	DanaGF16235	ML domain-containing protein. (162 aa)
	DanaGF19429	Uncharacterized protein; Belongs to the GMC oxidoreductase family. (722 aa)
	DanaGF17201	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (441 aa)
	DanaGF16669	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (397 aa)
	DanaGF17972	Uncharacterized protein. (768 aa)
	DanaGF17004	Uncharacterized protein. (836 aa)
	DanaGF24608	Uncharacterized protein, isoform A; Belongs to the cytochrome P450 family. (541 aa)
	DanaGF10456	Uncharacterized protein; Belongs to the cytochrome P450 family. (543 aa)
	DanaGF10095	Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
	DanaGF10649	Uncharacterized protein; Belongs to the cytochrome P450 family. (484 aa)
	DanaGF23785	Uncharacterized protein; Belongs to the cytochrome P450 family. (461 aa)
	GF24309	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. (266 aa)
	DanaGF24872	Uncharacterized protein. (685 aa)
	DanaGF24863	Uncharacterized protein; Belongs to the cytochrome P450 family. (507 aa)
	DanaGF24292	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (453 aa)
	DanaGF10349	Epimerase domain-containing protein. (416 aa)
	DanaGF11549	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	DanaGF12829	Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa)
	DanaGF13366	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (726 aa)
	DanaGF11407	VKc domain-containing protein. (161 aa)
	DanaGF12417	NADPH:adrenodoxin oxidoreductase, mitochondrial. (468 aa)
	DanaGF19784	Uncharacterized protein; Belongs to the cytochrome P450 family. (515 aa)
	DanaGF11817	Uncharacterized protein; Belongs to the cytochrome P450 family. (515 aa)
	DanaGF11816	Uncharacterized protein, isoform B; Belongs to the cytochrome P450 family. (539 aa)
	DanaGF11815	Uncharacterized protein; Belongs to the cytochrome P450 family. (517 aa)
	DanaGF12359	Uncharacterized protein; Belongs to the cytochrome P450 family. (526 aa)
	DanaGF12358	Uncharacterized protein, isoform A; Belongs to the cytochrome P450 family. (526 aa)
	DanaGF12588	Uncharacterized protein; Belongs to the cytochrome P450 family. (517 aa)
	DanaGF12357	Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa)
	DanaGF13683	Uncharacterized protein; Belongs to the GST superfamily. (231 aa)
	DanaGF11693	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (465 aa)
	DanaGF13196	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (319 aa)
	DanaGF14593	ML domain-containing protein. (148 aa)
	DanaGF15328	Uncharacterized protein. (370 aa)
	DanaGF14385	Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
	DanaGF14384	Uncharacterized protein; Belongs to the cytochrome P450 family. (511 aa)
	DanaGF14750	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (473 aa)
	DanaGF19699	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (292 aa)
	DanaGF15705	Uncharacterized protein, isoform A. (299 aa)
	DanaGF14130	Uncharacterized protein, isoform A. (1286 aa)
	v	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (380 aa)
	DanaGF21055	Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa)
	DanaGF20959	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (302 aa)
	DanaGF20885	ABC1 domain-containing protein. (681 aa)
	DanaGF22930	Uncharacterized protein; Belongs to the cytochrome P450 family. (535 aa)
	DanaGF23376	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (334 aa)
	DanaGF23062	Uncharacterized protein, isoform A. (456 aa)
	DanaGF23168	Uncharacterized protein. (522 aa)
	DanaGF24959	Methyltransf_12 domain-containing protein. (297 aa)
	DanaGF21887	Uncharacterized protein; Belongs to the cytochrome P450 family. (526 aa)
	DanaGF22543	Uncharacterized protein. (568 aa)
	DanaGF22398	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10095	DanaGF10456	B3M5G2	B3M3P2	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.817
DanaGF10095	DanaGF12417	B3M5G2	B3MEU2	Uncharacterized protein; Belongs to the cytochrome P450 family.	NADPH:adrenodoxin oxidoreductase, mitochondrial.	0.432
DanaGF10095	DanaGF13683	B3M5G2	B3MGW4	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the GST superfamily.	0.722
DanaGF10095	DanaGF20000	B3M5G2	B3MWZ4	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.515
DanaGF10095	DanaGF21986	B3M5G2	B3MYQ7	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.403
DanaGF10095	DanaGF22543	B3M5G2	B3MVQ6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.477
DanaGF10095	DanaGF23168	B3M5G2	B3MTT6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.938
DanaGF10095	DanaGF23376	B3M5G2	B3MTJ0	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.864
DanaGF10095	DanaGF24872	B3M5G2	B3M6N2	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.412
DanaGF10095	DanaGF24959	B3M5G2	B3MUK9	Uncharacterized protein; Belongs to the cytochrome P450 family.	Methyltransf_12 domain-containing protein.	0.595
DanaGF10095	DanaGF27071	B3M5G2	A0A0N8NZP3	Uncharacterized protein; Belongs to the cytochrome P450 family.	Rieske domain-containing protein.	0.918
DanaGF10349	DanaGF15705	B3M9B1	B3MP73	Epimerase domain-containing protein.	Uncharacterized protein, isoform A.	0.592
DanaGF10349	DanaGF16669	B3M9B1	B3M0D9	Epimerase domain-containing protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.807
DanaGF10349	DanaGF19699	B3M9B1	B3MN78	Epimerase domain-containing protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.461
DanaGF10349	DanaGF20959	B3M9B1	B3MRP4	Epimerase domain-containing protein.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.552
DanaGF10349	GF24309	B3M9B1	B3M6C8	Epimerase domain-containing protein.	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.	0.438
DanaGF10361	DanaGF21860	A0A0P8YAA8	B3N0J6	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.703
DanaGF10456	DanaGF10095	B3M3P2	B3M5G2	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.817
DanaGF10456	DanaGF10649	B3M3P2	B3M5Z6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.474
DanaGF10456	DanaGF11693	B3M3P2	B3MHU1	Uncharacterized protein; Belongs to the cytochrome P450 family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.408